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Article: Predictors of poststroke aphasia recovery: A systematic review-informed individual participant data meta-analysis

TitlePredictors of poststroke aphasia recovery: A systematic review-informed individual participant data meta-analysis
Authors
KeywordsSurvivor
Aphasia
Comprehension
Language
Demography
Issue Date2021
Citation
Stroke, 2021, v. 52, n. 5, p. 1778-1787 How to Cite?
AbstractBACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. CONCLUSIONS: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.
Persistent Identifierhttp://hdl.handle.net/10722/307446
ISSN
2023 Impact Factor: 7.8
2023 SCImago Journal Rankings: 2.450
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAli, Myzoon-
dc.contributor.authorVandenBerg, Kathryn-
dc.contributor.authorWilliams, Louise R.-
dc.contributor.authorWilliams, Linda J.-
dc.contributor.authorAbo, Masahiro-
dc.contributor.authorBecker, Frank-
dc.contributor.authorBowen, Audrey-
dc.contributor.authorBrandenburg, Caitlin-
dc.contributor.authorCopland, David A.-
dc.contributor.authorWorrall, Linda-
dc.contributor.authorBreitenstein, Caterina-
dc.contributor.authorBruehl, Stefanie-
dc.contributor.authorCranfill, Tamara B.-
dc.contributor.authordi Pietro-Bachmann, Marie-
dc.contributor.authorEnderby, Pamela-
dc.contributor.authorPalmer, Rebecca-
dc.contributor.authorFillingham, Joanne-
dc.contributor.authorGalli, Federica Lucia-
dc.contributor.authorGandolfi, Marialuisa-
dc.contributor.authorGlize, Bertrand-
dc.contributor.authorGodecke, Erin-
dc.contributor.authorHawkins, Neil-
dc.contributor.authorHilari, Katerina-
dc.contributor.authorHinckley, Jacqueline-
dc.contributor.authorHorton, Simon-
dc.contributor.authorHoward, David-
dc.contributor.authorJaecks, Petra-
dc.contributor.authorJefferies, Elizabeth-
dc.contributor.authorJesus, Luis M.T.-
dc.contributor.authorKambanaros, Maria-
dc.contributor.authorKang, Eun Kyoung-
dc.contributor.authorKhedr, Eman M.-
dc.contributor.authorKong, Anthony Pak Hin-
dc.contributor.authorKukkonen, Tarja-
dc.contributor.authorLaganaro, Marina-
dc.contributor.authorRalph, Matthew A.Lambon-
dc.contributor.authorLaska, Ann Charlotte-
dc.contributor.authorLeemann, Béatrice-
dc.contributor.authorLeff, Alexander P.-
dc.contributor.authorLima, Roxele R.-
dc.contributor.authorLorenz, Antje-
dc.contributor.authorWhinney, Brian Mac-
dc.contributor.authorMarshall, Rebecca Shisler-
dc.contributor.authorMattioli, Flavia-
dc.contributor.authorMaviş, Ilknur-
dc.contributor.authorMeinzer, Marcus-
dc.contributor.authorNilipour, Reza-
dc.contributor.authorNoé, Enrique-
dc.contributor.authorPaik, Nam Jong-
dc.contributor.authorPapathanasiou, Ilias-
dc.contributor.authorPatricio, Brigida F.-
dc.contributor.authorMartins, Isabel Pavão-
dc.contributor.authorPrice, Cathy-
dc.contributor.authorJakovac, Tatjana Prizl-
dc.contributor.authorRochon, Elizabeth-
dc.contributor.authorRose, Miranda L.-
dc.contributor.authorRosso, Charlotte-
dc.contributor.authorRubi-Fessen, Ilona-
dc.contributor.authorRuiter, Marina B.-
dc.contributor.authorSnell, Claerwen-
dc.contributor.authorStahl, Benjamin-
dc.contributor.authorSzaflarski, Jerzy P.-
dc.contributor.authorThomas, Shirley A.-
dc.contributor.authorvan de Sandt-Koenderman, Mieke-
dc.contributor.authorvan der Meulen, Ineke-
dc.contributor.authorVisch-Brink, Evy-
dc.contributor.authorWright, Heather Harris-
dc.contributor.authorBrady, Marian C.-
dc.date.accessioned2021-11-03T06:22:37Z-
dc.date.available2021-11-03T06:22:37Z-
dc.date.issued2021-
dc.identifier.citationStroke, 2021, v. 52, n. 5, p. 1778-1787-
dc.identifier.issn0039-2499-
dc.identifier.urihttp://hdl.handle.net/10722/307446-
dc.description.abstractBACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. CONCLUSIONS: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.-
dc.languageeng-
dc.relation.ispartofStroke-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectSurvivor-
dc.subjectAphasia-
dc.subjectComprehension-
dc.subjectLanguage-
dc.subjectDemography-
dc.titlePredictors of poststroke aphasia recovery: A systematic review-informed individual participant data meta-analysis-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1161/STROKEAHA.120.031162-
dc.identifier.pmid33719515-
dc.identifier.pmcidPMC8078126-
dc.identifier.scopuseid_2-s2.0-85104977819-
dc.identifier.volume52-
dc.identifier.issue5-
dc.identifier.spage1778-
dc.identifier.epage1787-
dc.identifier.eissn1524-4628-
dc.identifier.isiWOS:000644656300040-

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