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Article: Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment

TitleCirculating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment
Authors
Issue Date2020
PublisherNature Publishing Group. The Journal's web site is located at http://www.pedresearch.org/
Citation
Pediatric Research, 2020, Epub 2020-07-07 How to Cite?
AbstractBackground: We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. Methods: In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after completion of chemotherapy were determined in 40 children with newly diagnosed acute leukaemia. Results: Significant reduction of LV global longitudinal strain and strain rates were found within 1 week after completion of anthracycline therapy in the induction phase of treatment (all p < 0.05). Hs-cTnT level peaked and miR-1 increased significantly at this time point. Log-transformed hs-cTnT correlated negatively with LV global systolic longitudinal strain (r = −0.38, p < 0.001). Receiver operating characteristic analysis revealed that area under the curve for changes in plasma hs-cTnT from baseline and plasma miR-1 levels in detecting a reduction in ≥20% of global longitudinal strain were respectively 0.62 (95% CI 0.38−0.87) and 0.62 (95% CI 0.40−0.84). Conclusion: Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias.
Persistent Identifierhttp://hdl.handle.net/10722/284668
ISSN
2019 Impact Factor: 2.747
2015 SCImago Journal Rankings: 1.290

 

DC FieldValueLanguage
dc.contributor.authorCheung, YF-
dc.contributor.authorLi, VWY-
dc.contributor.authorLai, CTM-
dc.contributor.authorShin, VY-
dc.contributor.authorKeung, W-
dc.contributor.authorCheuk, DKL-
dc.contributor.authorKwong, A-
dc.contributor.authorLi, RA-
dc.contributor.authorChan, GCF-
dc.date.accessioned2020-08-07T09:00:58Z-
dc.date.available2020-08-07T09:00:58Z-
dc.date.issued2020-
dc.identifier.citationPediatric Research, 2020, Epub 2020-07-07-
dc.identifier.issn0031-3998-
dc.identifier.urihttp://hdl.handle.net/10722/284668-
dc.description.abstractBackground: We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. Methods: In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after completion of chemotherapy were determined in 40 children with newly diagnosed acute leukaemia. Results: Significant reduction of LV global longitudinal strain and strain rates were found within 1 week after completion of anthracycline therapy in the induction phase of treatment (all p < 0.05). Hs-cTnT level peaked and miR-1 increased significantly at this time point. Log-transformed hs-cTnT correlated negatively with LV global systolic longitudinal strain (r = −0.38, p < 0.001). Receiver operating characteristic analysis revealed that area under the curve for changes in plasma hs-cTnT from baseline and plasma miR-1 levels in detecting a reduction in ≥20% of global longitudinal strain were respectively 0.62 (95% CI 0.38−0.87) and 0.62 (95% CI 0.40−0.84). Conclusion: Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.pedresearch.org/-
dc.relation.ispartofPediatric Research-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.titleCirculating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment-
dc.typeArticle-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.emailLi, VWY: wyvli@hku.hk-
dc.identifier.emailShin, VY: vyshin@hku.hk-
dc.identifier.emailKeung, W: wkeung@hku.hk-
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.authorityCheung, YF=rp00382-
dc.identifier.authorityShin, VY=rp02000-
dc.identifier.authorityKeung, W=rp01887-
dc.identifier.authorityKwong, A=rp01734-
dc.identifier.authorityLi, RA=rp01352-
dc.identifier.authorityChan, GCF=rp00431-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41390-020-1049-5-
dc.identifier.scopuseid_2-s2.0-85087633061-
dc.identifier.hkuros311564-
dc.identifier.volumeEpub 2020-07-07-
dc.publisher.placeUnited States-

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