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Article: Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment
Title | Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment |
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Authors | |
Issue Date | 2020 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.pedresearch.org/ |
Citation | Pediatric Research, 2020, Epub 2020-07-07 How to Cite? |
Abstract | Background:
We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment.
Methods:
In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after completion of chemotherapy were determined in 40 children with newly diagnosed acute leukaemia.
Results:
Significant reduction of LV global longitudinal strain and strain rates were found within 1 week after completion of anthracycline therapy in the induction phase of treatment (all p < 0.05). Hs-cTnT level peaked and miR-1 increased significantly at this time point. Log-transformed hs-cTnT correlated negatively with LV global systolic longitudinal strain (r = −0.38, p < 0.001). Receiver operating characteristic analysis revealed that area under the curve for changes in plasma hs-cTnT from baseline and plasma miR-1 levels in detecting a reduction in ≥20% of global longitudinal strain were respectively 0.62 (95% CI 0.38−0.87) and 0.62 (95% CI 0.40−0.84).
Conclusion:
Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias. |
Persistent Identifier | http://hdl.handle.net/10722/284668 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.184 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheung, YF | - |
dc.contributor.author | Li, VWY | - |
dc.contributor.author | Lai, CTM | - |
dc.contributor.author | Shin, VY | - |
dc.contributor.author | Keung, W | - |
dc.contributor.author | Cheuk, DKL | - |
dc.contributor.author | Kwong, A | - |
dc.contributor.author | Li, RA | - |
dc.contributor.author | Chan, GCF | - |
dc.date.accessioned | 2020-08-07T09:00:58Z | - |
dc.date.available | 2020-08-07T09:00:58Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pediatric Research, 2020, Epub 2020-07-07 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284668 | - |
dc.description.abstract | Background: We investigated whether plasma high-sensitivity cardiac troponin T (hs-cTnT) and circulating heart-associated microRNA (miRs) are increased in children with leukaemias during anthracycline-based chemotherapeutic treatment. Methods: In vitro human pluripotent stem cell (hPSC)-derived cardiomyocyte model showed that miR-1, miR-133a, miR-208a, miR-208b, and miR-499 are released from cells into culture medium in a time- and dose-dependent manner on doxorubicin exposure. Left ventricular (LV) myocardial deformation and circulating heart-associated miRs and plasma hs-cTnT during and after completion of chemotherapy were determined in 40 children with newly diagnosed acute leukaemia. Results: Significant reduction of LV global longitudinal strain and strain rates were found within 1 week after completion of anthracycline therapy in the induction phase of treatment (all p < 0.05). Hs-cTnT level peaked and miR-1 increased significantly at this time point. Log-transformed hs-cTnT correlated negatively with LV global systolic longitudinal strain (r = −0.38, p < 0.001). Receiver operating characteristic analysis revealed that area under the curve for changes in plasma hs-cTnT from baseline and plasma miR-1 levels in detecting a reduction in ≥20% of global longitudinal strain were respectively 0.62 (95% CI 0.38−0.87) and 0.62 (95% CI 0.40−0.84). Conclusion: Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.pedresearch.org/ | - |
dc.relation.ispartof | Pediatric Research | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.title | Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment | - |
dc.type | Article | - |
dc.identifier.email | Cheung, YF: xfcheung@hku.hk | - |
dc.identifier.email | Li, VWY: wyvli@hku.hk | - |
dc.identifier.email | Shin, VY: vyshin@hku.hk | - |
dc.identifier.email | Keung, W: wkeung@hku.hk | - |
dc.identifier.email | Cheuk, DKL: klcheuk@hkucc.hku.hk | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.email | Li, RA: ronaldli@hkucc.hku.hk | - |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | - |
dc.identifier.authority | Cheung, YF=rp00382 | - |
dc.identifier.authority | Shin, VY=rp02000 | - |
dc.identifier.authority | Keung, W=rp01887 | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.identifier.authority | Li, RA=rp01352 | - |
dc.identifier.authority | Chan, GCF=rp00431 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/s41390-020-1049-5 | - |
dc.identifier.scopus | eid_2-s2.0-85087633061 | - |
dc.identifier.hkuros | 311564 | - |
dc.identifier.volume | Epub 2020-07-07 | - |
dc.identifier.isi | WOS:000547213600001 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0031-3998 | - |