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Article: Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension

TitleUntreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension
Authors
Keywordsbrain natriuretic peptide
hypertension
obstructive sleep apnea
troponin
Issue Date2018
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.aasmnet.org/jcsm
Citation
The Journal of Clinical Sleep Medicine, 2018, v. 14 n. 11, p. 1841-1847 How to Cite?
AbstractSTUDY OBJECTIVES: Obstructive sleep apnea (OSA) and hypertension are independent risk factors of cardiovascular morbidities. This study aims to investigate the relationship between OSA, blood pressure (BP) control, and myocardial injury in patients with difficult-to-control hypertension. METHODS: Patients with hypertension who required three or more medications were prospectively recruited at a tertiary referral center. In-laboratory polysomnography, followed by blood tests for fasting glucose, glycated hemoglobin, lipids, high-sensitivity troponin I (hsTnI), B-type natriuretic peptide (BNP), C-reactive protein, and advanced oxidation protein products were performed. After polysomnography, 24-hour ambulatory BP monitoring was arranged. RESULTS: A total of 98 participants were analyzed, with mean age 51 ± 9 years and body mass index 30 ± 5 kg/m2. Previously undiagnosed severe OSA (apneahypopnea index [AHI] ≥ 30 events/h) was present in 51 patients (52%). hsTnI was negatively correlated with nocturnal dip in systolic BP (r = -.205, P = .048). After controlling for confounders, including BP control, AHI and oxygen desaturation index (ODI) were positively correlated with hsTnI (r = .282, P = .009 and r = .279, P = .010, respectively) and C-reactive protein (r = .302, P = .005 and r = .285, P = .008, respectively), but not with BNP or advanced oxidation protein products. Age, ODI, and loss of nocturnal systolic BP dip were significant determinants of hsTnI level (β = .225, P = .022; β = .293, P = .003; and β = -.215, P = .029; R2 = .151). Age, female sex, 24-hour mean diastolic BP, and metabolic syndrome, but not indices of apnea severity, were predictors of BNP level. CONCLUSIONS: Unrecognized severe OSA was common in patients with difficult-to-control hypertension, and OSA severity was associated with myocardial injury, independent of BP control with medications. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov, Title: A Cross-sectional Study of the Occurrence and Effect of Obstructive Sleep Apnea in Subjects With Resistant Hypertension, Identifier: NCT00843583, URL: https://clinicaltrials.gov/ct2/show/NCT00843583. © 2018 American Academy of Sleep Medicine.
DescriptionLink to Free access
Persistent Identifierhttp://hdl.handle.net/10722/273945
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.039
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, MMS-
dc.contributor.authorTse, HF-
dc.contributor.authorMak, JCW-
dc.contributor.authorLam, DCL-
dc.contributor.authorChan, CWS-
dc.contributor.authorChong, WC-
dc.contributor.authorIp, MSM-
dc.date.accessioned2019-08-18T14:51:53Z-
dc.date.available2019-08-18T14:51:53Z-
dc.date.issued2018-
dc.identifier.citationThe Journal of Clinical Sleep Medicine, 2018, v. 14 n. 11, p. 1841-1847-
dc.identifier.issn1550-9389-
dc.identifier.urihttp://hdl.handle.net/10722/273945-
dc.descriptionLink to Free access-
dc.description.abstractSTUDY OBJECTIVES: Obstructive sleep apnea (OSA) and hypertension are independent risk factors of cardiovascular morbidities. This study aims to investigate the relationship between OSA, blood pressure (BP) control, and myocardial injury in patients with difficult-to-control hypertension. METHODS: Patients with hypertension who required three or more medications were prospectively recruited at a tertiary referral center. In-laboratory polysomnography, followed by blood tests for fasting glucose, glycated hemoglobin, lipids, high-sensitivity troponin I (hsTnI), B-type natriuretic peptide (BNP), C-reactive protein, and advanced oxidation protein products were performed. After polysomnography, 24-hour ambulatory BP monitoring was arranged. RESULTS: A total of 98 participants were analyzed, with mean age 51 ± 9 years and body mass index 30 ± 5 kg/m2. Previously undiagnosed severe OSA (apneahypopnea index [AHI] ≥ 30 events/h) was present in 51 patients (52%). hsTnI was negatively correlated with nocturnal dip in systolic BP (r = -.205, P = .048). After controlling for confounders, including BP control, AHI and oxygen desaturation index (ODI) were positively correlated with hsTnI (r = .282, P = .009 and r = .279, P = .010, respectively) and C-reactive protein (r = .302, P = .005 and r = .285, P = .008, respectively), but not with BNP or advanced oxidation protein products. Age, ODI, and loss of nocturnal systolic BP dip were significant determinants of hsTnI level (β = .225, P = .022; β = .293, P = .003; and β = -.215, P = .029; R2 = .151). Age, female sex, 24-hour mean diastolic BP, and metabolic syndrome, but not indices of apnea severity, were predictors of BNP level. CONCLUSIONS: Unrecognized severe OSA was common in patients with difficult-to-control hypertension, and OSA severity was associated with myocardial injury, independent of BP control with medications. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov, Title: A Cross-sectional Study of the Occurrence and Effect of Obstructive Sleep Apnea in Subjects With Resistant Hypertension, Identifier: NCT00843583, URL: https://clinicaltrials.gov/ct2/show/NCT00843583. © 2018 American Academy of Sleep Medicine.-
dc.languageeng-
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.aasmnet.org/jcsm-
dc.relation.ispartofThe Journal of Clinical Sleep Medicine-
dc.subjectbrain natriuretic peptide-
dc.subjecthypertension-
dc.subjectobstructive sleep apnea-
dc.subjecttroponin-
dc.titleUntreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension-
dc.typeArticle-
dc.identifier.emailLui, MMS: drmslui@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailMak, JCW: judithmak@hku.hk-
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.emailChan, CWS: drwschan@hkucc.hku.hk-
dc.identifier.emailChong, WC: peonyki@hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityMak, JCW=rp00352-
dc.identifier.authorityLam, DCL=rp01345-
dc.identifier.authorityIp, MSM=rp00347-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5664/jcsm.7476-
dc.identifier.pmid30373683-
dc.identifier.pmcidPMC6223564-
dc.identifier.scopuseid_2-s2.0-85056634990-
dc.identifier.hkuros302173-
dc.identifier.volume14-
dc.identifier.issue11-
dc.identifier.spage1841-
dc.identifier.epage1847-
dc.identifier.isiWOS:000461414800004-
dc.publisher.placeUnited States-
dc.identifier.issnl1550-9389-

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