Contact Information
Dr Judith Mak 麥翠和
Title:
Principal Lecturer
Department:
Faculty:
Curriculum Vitae:
Research Interests:(click to check for cognate researchers)
- Investigating the effects of specific pathway inhibitors on the primary cell response to inflammation in the airway epithelium.
- Elucidation of pathophysiological pathways in rodent models of chronic airway diseases such as chronic obstructive pulmonary disease (COPD) (i.e. cigarette smoke-exposed rat model or ozone-exposed mouse model), asthma (i.e. ovalbumin sensitized allergen challenged mouse model), and obstructive sleep apnea (OSA) [i.e. intermittent hypoxia-exposed rat model].
- Translational research using focused therapeutic tool compounds such as various antioxidants including pure EGCG (the major catechin in Chinese green tea) in human primary cells and then to various rodent models in vivo to identify new targets and pathways.
- Examining the cellular mechanisms of adipokine and serotonin function in chronic airway diseases.
Also Cited As:
Mak, JC
Mak, J
Professional Qualifications
Biography
Dr. Judith Mak is currently Principal Lecturer of Department of Pharmacology and Pharmacy. She received her degree in Pharmacology (BSc) from The University of London in the UK. She then completed her PhD in localization of lung receptors (‘Localization of some pharmacological receptors in human and animal lung’) at the University of London under the supervision of Professor Peter J. Barnes. Following her postdoctoral training and Lecturership in the research areas for the treatment of chronic obstructive lung diseases at the National Heart & Lung Institute of Imperial College London, she returned to Hong Kong in 2002 and joined the Department of Medicine, University of Hong Kong, where she went through the ranks of Research Assistant Professor, Assistant Professor and Associate Professor before becoming Principal Lecturer. Her research interest is mainly focused on cellular and molecular mechanisms of asthma and chronic obstructive pulmonary disease (COPD), understanding and developing therapies. Her major research contributions have been in the understanding of the development of b2-agonist tolerance, and the interaction between glucocorticoid receptors and b2-adrenoceptors in the intracellular signaling pathways leading to the combination therapy of long-acting inhaled b2-agonist and inhaled glucocorticoid (e.g. SymbicortÒ and SeretideÒ). She is an internationally recognized scientist in the respiratory field. She has collaborated with academic researchers, both locally and internationally on cross-disciplinary projects. She is the principal investigator and co-investigator of a number of research projects funded by RGC, HMRF and NSFC.
Honours, Awards & Prizes
Professional Societies
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