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Conference Paper: Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS)
Title | Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS) |
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Authors | |
Issue Date | 2014 |
Publisher | ISMRM-ESMRMB 2014. |
Citation | The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite? |
Abstract | This study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) to detect and characterize the ECM degradation during the early stage of IVDD. The apparent diffusion coefficient (ADC) of macromolecule resonances increased by approximately ten fold immediately after papain injection, and continued to increase in the following 5 days. The macromolecule T2 also had a slight increase during the ECM degradation and the macromolecule content is corrected by their corresponding T2 value. The macromolecule content, water T2 and ADC value showed a delayed change compared to the macromolecule ADCs. The macromolecule ADC is an early marker of the microstructural breakdown of PGs and collagen network in the disc NP during IVDD and hence DW-MRS is sensitive to detect disc degeneration at an early stage. |
Description | Traditional Poster Session - Musculoskeleta: Spine: no. 1245 |
Persistent Identifier | http://hdl.handle.net/10722/204141 |
DC Field | Value | Language |
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dc.contributor.author | Wang, AM | en_US |
dc.contributor.author | Tsang, AHW | en_US |
dc.contributor.author | Cao, P | en_US |
dc.contributor.author | Chan, D | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.date.accessioned | 2014-09-19T20:06:39Z | - |
dc.date.available | 2014-09-19T20:06:39Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/204141 | - |
dc.description | Traditional Poster Session - Musculoskeleta: Spine: no. 1245 | - |
dc.description.abstract | This study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) to detect and characterize the ECM degradation during the early stage of IVDD. The apparent diffusion coefficient (ADC) of macromolecule resonances increased by approximately ten fold immediately after papain injection, and continued to increase in the following 5 days. The macromolecule T2 also had a slight increase during the ECM degradation and the macromolecule content is corrected by their corresponding T2 value. The macromolecule content, water T2 and ADC value showed a delayed change compared to the macromolecule ADCs. The macromolecule ADC is an early marker of the microstructural breakdown of PGs and collagen network in the disc NP during IVDD and hence DW-MRS is sensitive to detect disc degeneration at an early stage. | - |
dc.language | eng | en_US |
dc.publisher | ISMRM-ESMRMB 2014. | - |
dc.relation.ispartof | ISMRM-ESMRMB 2014 Annual Meeting | en_US |
dc.title | Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS) | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Tsang, AHW: ahwtsang@hku.hk | en_US |
dc.identifier.email | Cao, P: caopeng1@hku.hk | - |
dc.identifier.email | Chan, D: chand@hku.hk | - |
dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | - |
dc.identifier.authority | Chan, D=rp00540 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 240608 | en_US |
dc.publisher.place | Italy | en_US |