Name Card
Man, Kwan 萬鈞
Title:
Professor, Chair of Transplant Oncology and Immunology
Professor
Department:
Faculty:
Contact Information
Man, Kwan 萬鈞
Title:
Professor, Chair of Transplant Oncology and Immunology
Professor
Department:
Faculty:
Research Interests:(click to check for cognate researchers)
Also Cited As:
Nancy K Man
Professional Qualifications
| Year | Awarding Institution | Qualification |
|---|---|---|
| MBBS | ||
| MS | ||
| 1998 | The University of Hong Kong | PhD |
Biography
The long-term strategic goal of my research is to improve the outcomes of liver transplantation by reducing the graft injury through integrated basic, clinical and translational studies. I have developed a series of novel animal models to mimic liver graft injury and cancer recurrence. I am first to establish a rat orthotopic liver transplantation model using small-for-size graft in Hong Kong. These models have been extensively introduced into the investigation of liver transplantation. For example, the correlation between transient portal hypertension resulted from excessive portal flow and hepatic sinusoidal damage of small-for-size liver graft was first revealed in animal model we established and the finding was subsequently validated in a series of our clinical studies. The further studies for the mechanism of graft injury and novel treatments were also conducted in animal models we established. We are first to report the significance of small-for-size liver graft injury on tumor recurrence after transplantation in the world and further to explore the molecular mechanisms of inflammatory response in acute phase and tumor invasiveness in late phase. We are also first to uncover the precise mechanism of marginal liver graft injury in our novel rat model of liver transplantation using small-for-size fatty grafts. In parallel, I have focused on the molecular mechanisms involved inflammation and cancer progression, together with the development of novel therapies for cancer metastasis. In addition, I have also established the research platform for in vivo small animal imaging modalities, which are widely applied in various research fields in the Faculty.
I am currently the Regional Associate Editor (Asia) of Transplantation and Associate Editor of Liver Transplantation. I am also the member of the Basic Science Committee of Liver Transplantation Society (ILTS) as well as The Transplantation Society (TTS), Chairperson of ILTS Scholarship Committee, member of ILTS Education Committee, Founder member of Women Leaders in Transplantation (WLIL), International Mentor of WLIL and a Key Opinion Leader of TTS. I have published more than 100 original articles in international journals with H index 29 (total citation >3900). I and my research team have obtained more than 27 international awards including numerous “Rising Star Awards”, “Young Investigator Awards” in annual congress of ILTS, and “Mentee-Mentor Basic Science Awards” In TTS meetings over the past 7 years.
Honours, Awards & Prizes
| Awardees | Award Date | Honours / Awards / Prizes | Category |
|---|---|---|---|
LONG, Runying DING, Tao ZHANG, Qingmei | 2024-05-01 | Young Investigator Award - CXCR6+CD69+ liver-resident memory CD8+ T cells (TRM) limit HCC recurrence after LDLT via potentiating immune surveillance. In: The 2024 Annual Congress of ILTS: The 2024 International Congress of ILTS (International Liver Transplantation Society) (01/05/2024-04/05/2024, Houston) | Research Achievement |
Yeung, WHO Ma, YY ZHONG, Rongrong HUANG, Yunxiao | 2024-04-19 | Geneva Gold Medal Award: The 49th Geneva International Exhibition of Inventions 2024 (17/04/2024-21/04/2024, Geneva) | Others |
Yeung, WHO Ma, YY ZHONG, Rongrong HUANG, Yunxiao | 2024-04-19 | China Association of Inventions (CAI) Award Invention & Innovation: The 49th Geneva International Exhibition of Inventions 2024 (17/04/2024-21/04/2024, Geneva) | Others |
| 2005-07-20 | Young Investigator Award - "Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation": The 11th Annual Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005 | Research Achievement | |
| 2014-07-28 | International TTS Basic Science Mentor Award: 2014 World Transplant Congress, San Francisco, USA, 26-31 July 2014 | Research Achievement | |
| 2013-12-02 | 自然科學獎一等獎 | Research Achievement | |
| 2013-11-09 | International TTS Basic Science Mentor Award: XIII TTS Basic Science Symposium, Paris, France, 7-9 November 2013 | Research Achievement | |
| 2003-06-18 | Best Oral Presentation Award, FTY720 attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway: The 9th Congress of the International Liver Transplantation Society and 13th Congress of the Liver Intensive Care Group of Europe, Barcelona, Spain, 18-21 June 2003 | Research Achievement | |
| 2005-12-02 | Distinguished Scientific Award - "Significant activation of cell invasion and migration pathways in small-for-size grafts potentially increase tumor recurrence after LDLT": The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005 | Research Achievement | |
| 2005-07-01 | Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation: 11th International Liver Transplantation Society Conference, LA, July 20-23, 2005 | Research Achievement | |
| 2003-06-09 | Young Investigator Travel Award, Hepartic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways: 10th International Liver Transplantation Society Conference, Kyoto, Japan, 9 - 12 June 2004 | Research Achievement | |
Liu, Y Liu, X Cheng, Q de Villa, MVH | 2009-07-08 | The distinct regeneration pattern of small-for-size fatty liver graft - the significance of aldose reductase signaling on oval cell activation (Travel Award): The 15th Annual International Congress of the International Liver Transplant Society, New York City, New York, U.S.A., 8 - 11 July 2009 | Research Achievement |
| 2008-04-12 | AACR Scholar in Training Award - "Angiopoietin-like protein 4 suppresses liver tumor growth and metastases by inhibition of angiogenesis and cell invasion": The Annual Meeting of the American Association for Cancer Research, San Diego, California, U.S.A., 12 - 16 April 2008 | Research Achievement | |
| 2006-05-03 | Rising Star Research Award - "The significance of graft size on tumor recurrence/metastases after liver transplantation - activation of cell invasion and migration pathways": The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006 | Research Achievement | |
| 2007-12-01 | Outstanding Poster Presentation Award - "Functional characterization of homeoprotein Six1 in hepatocellular carcinoma": The 12th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 12 - 14 December 2007 | Research Achievement | |
Liu, X Cheng, Q Geng, W | 2011-06-22 | Young Investigator Travel Award - The role of interferon-gamma inducible protein 10 (IP10) in early-phase graft injury induced cisplatin resistance after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011 | Research Achievement |
LING, Changchun QI, Xiang Liu, X Geng, W Li, C | 2011-06-22 | Young Investigator Travel Award - The role of glutathione peroxidase 3 (GPx3): bridging liver graft injury and tumor invasiveness after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011 | Research Achievement |
Yeung, WHO | 2018-06-01 | Mentor Mentee Award: The Transplantation Society 2018 International Congress | Research Achievement |
Yeung, WHO | 2018-05-01 | Rising Star Award: The 2018 Joint International Congress of ILTS, ELITA & LICAGE | Research Achievement |
LING, Changchun Liu, X Li, C Shao, Y Ma, YY | 2011-06-22 | Rising Star Award - Aldose reductase accelerates hepatic ischemia reperfusion injury via IP10/TLR4 signaling (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011 | Research Achievement |
| 2017-11-01 | Best Poster Presentation Award of Hong Kong Socienty for Immunology Forum 2017: Hong Kong Socienty for Immunology | Research Achievement | |
| 2018-05-01 | Young Investigator Award of International Liver Transplantation Society Annual Congress: International Liver Transplantation Society | Research Achievement | |
Li, C | 2015-11-01 | Mentee and Mentor Travel Award: The 14th Transplantation Science Symposium, Lorne, Australia, 11-13 November 2015 | Research Achievement |
Li, C Ma, YY Law, CFBC | 2012-05-01 | 2012Young Investigator Travel Award: Liver Transplantation ISSN: 1527-6465 ; eISSN: 1527-6473 | Research Achievement |
QI, Xiang LI, Changxian Liu, X Geng, W Ma, YY Ling, C | 2012-07-01 | The Transplantation Society International Basic Science Mentee-Mentor Travel Award (Paper titled "Acute phase graft injury promotes tumor invasiveness through down-regulation of Glutathione Peroxidase 3 (GPx3) after liver transplantation"): The 24th International Congress of The Transplantation Society, Berlin, Germany, 15-19 July 2012 | Research Achievement |
Li, C | 2012-05-01 | Acute phase circulating microRNAs predict tumor recurrence and survivals of hepatocellular carcinoma patients after liver transplantation: Young Investigator Award, the 18th Annual International Congress of the International Liver Transplantation Society, San Francisco, California, U.S.A., 16 - 19 May 2012 | Research Achievement |
WANG, Yudong | 2011-06-22 | Young Investigator Travel Award - Intravenous and intrathecal morphine treatment attenuates hepatic ischemia-reperfusion injury in a rat model (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011 | Research Achievement |
LING, Changchun QI, Xiang Liu, X Geng, W Li, C | 2011-06-11 | International TTS Basic Science Symposium Mentee/Mentor Travel Award - Down-regulation of glutathione peroxidase 3 (GPx3) by acute phase inflammation in small-for-size graft promotes tumor invasiveness after liver transplantation (Abstract): XII TTS Basic Science Symposium and II ESOT Basic Science Meeting, Boston, USA, 11-14 June 2011 | Research Achievement |
LING, Changchun Liu, X Li, C Shao, Y Ma, YY | 2011-06-11 | International TTS Basic Science Symposium Mentee/Mentor Travel Award - Aldose reductase accelerates small-for-size fatty liver graft injury (Abstract): XII TTS Basic Science Symposium and II ESOT Basic Science Meeting, Boston, USA, 11-14 June 2011 | Research Achievement |
Liu, X Li, C | 2010-06-16 | Acute phase liver graft injury significantly mobilized circulating endothelial progenitor cells, myeloid-derived suppressor cells and regulatory T cells (Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010 | Research Achievement |
Liu, X Geng, W Li, C | 2010-06-30 | MicroRNA signatures associated with acute phase small-for size liver graft injury and tumor invasiveness (Young Investigator Award): The 16th International Liver Transplantation Society Congress, Hong Kong, 16-19 June 2010 | Research Achievement |
Liu, X Li, C Shao, Y | 2010-06-16 | FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells, myeloid-derived suppressor cells and regulatory T cells
(Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010 | Research Achievement |
Liu, Y Liu, X Cheng, Q Geng, W | 2010-06-16 | The potential role of early-phase liver graft injury in induction of late-phase chemoresistance after liver transplantation (Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010 | Research Achievement |
CHENG, Qiao Liu, Y Liu, X | 2010-06-01 | Epithelial to mesenchymal transition in development of liver fibrosis in small-for-size fatty liver graft (Rising Star Award): The 16th International Liver Transplantation Society Congress, Hong Kong, 16-19 June 2010 | Research Achievement |
| 2007-06-01 | Rising Star Researcher Award: International Liver Transplantation Society | Research Achievement | |
Cheung, KYC | 2011-06-22 | Young Investigator Travel Award - Differential replication of hepatitis B virus mutants in recurrent hepatocellular carcinoma after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011 | Research Achievement |
Xiao, J | 2007-06-20 | Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts": The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007 | Research Achievement |
LIU, Jiang Yeung, WHO | 2023-08-28 | Best Abstract Award: The 18th Congress of Asian Society of Transplantation (23/08/2023-28/08/2023, Hong Kong) | Research Achievement |
Yang, X | 2023-08-28 | Best Abstract Award: The 18th Congress of Asian Society of Transplantation (23/08/2023-28/08/2023, Hong Kong) | Research Achievement |
Liu, X Geng, W Li, C | 2014-12-01 | 2014中华医学科技奖一等奖 (活体肝移植的创新性研究) | Research Achievement |
Yang, X | 2024-03-24 | Young Investigator Award - The Hong Kong Society for Immunology Annual Congress 2023/2024 | Research Achievement |
Bian, C | 2024-03-23 | Best Poster Award - The Hong Kong Society for Immunology Annual Congress 2023/24: The Hong Kong Society for Immunology Annual Congress 2023/24 (23/03/2024-23/03/2024, Hong Kong) | Research Achievement |
| 2021-05-01 | Rising Star Award (Mentor): International Liver Transplantation Society 2021 Annual Congress (Virtual), 5-8 May 2021 | Research Achievement | |
LAM, Yin Fan | 2018-05-01 | Young Investigator Award (Title: Prognostic role of exosomal miR-1290 in hepatocellular carcinoma recurrence after curative treatments.): the 2018 Joint International Congress of ILTS, ELITA & LICAGE, Lisbon, Portugal, 23-26 May 2018 | Research Achievement |
QI, Xiang | 2016-08-01 | Mentor-Mentee Award: The 26th International Congress of The Transplantation Society, Hong Kong, China, 18-23 August 2016 | Research Achievement |
JIAN, Zheng DING, Tao Bian, C | 2024-05-04 | Young Investigator Award - The 2024 Annual Congress of ILTS: Aberrant unsaturated fatty acid elongation mediated by ELOVL1 in steatotic grafts facilitates HCC recurrence. International Liver Transplantation Society. 4 May 2024. Houston, USA: The 2024 Annual Congress of ILTS (01/05/2024-04/05/2024, Houston) | Research Achievement |
PANG, Li Liu, H | 2019-05-01 | ILTS Travel Award - Plasmacytoid dendritic cells promote hepatocellular carcinoma recurrence after liver transplantation: ILTS 25th Annual International Congress, May 2019, Toronto, Canada | Research Achievement |
Bian, C JIAN, Zheng DING, Tao | 2024-05-01 | Young Investigator Award - Aberrant unsaturated fatty acid elongation mediated by ELOVL1 in steatotic grafts facilitates HCC recurrence after transplantation. In: The 2024 Annual Congress of ILTS: The 2024 International Congress of ILTS (International Liver Transplantation Society) (01/05/2024-04/05/2024, Houston) | Research Achievement |
YANG, Xinxiang Liu, X Qi, X Liu, H Zhou, J | 2018-05-01 | Young Investigator Award (Title: Glutathione peroxidase 3 (GPx3) suppressed tumor growth and ameliorated hepatic IR injury via modulating autophagy): the 2018 Joint International Congress of ILTS, ELITA & LICAGE May 23 – 26, 2018 in Lisbon, Portugal. | Research Achievement |
WANG, Zhe DENG, Libin ZENG, Shinuan | 2024-05-01 | Young Investigator Award - Tumor-derived exosomal FTH1 impaired antitumor function of CD8+ T cells via ferroptosis in hepatocellular carcinoma. In: The 2024 Annual Congress of ILTS: The 2024 International Congress of ILTS (International Liver Transplantation Society) (01/05/2024-04/05/2024, Houston) | Research Achievement |
Professional Societies
| Term Period | Position | Professional Societies |
|---|---|---|
| Since 2003 | Full member | International Liver Transplantation Society |
| Since 2012 | Committee member | Basic Science Committee of The Transplantation Society (TTS) |
| Since 2005 | International member | American Society of Transplantation |
| Since 2010 | Founder member and international turor | Worman in Transplantation of TTS |
| Since 2007 | Committee Member | Basic Science Committee of ILTS |
| Since 2003 | Full member | The Transplantation society |
| Since 2005 | Active member | Centre for Cancer Research, LKS Facuty of Medicine, HKU |
| Since 2009 | Founder Member | Founder member of Women Leaders in Transplantation |
| Since 2007 | Committee Member | Scholar review Committee of ILTS |
| Since 2011 | Committee member | Education Committee of ILTS |
| Since 2010 | Chair | Scholarship Commmittee of ILTS |
| Since 2006 | Active member | American Assoiation of Cancer Research |
| Since 2007 | Member | International Liver Cancer Association |
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