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Article: Acute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosis

TitleAcute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosis
Authors
KeywordsComplications of HBV reactivation
Extrahepatic manifestation of HBV
High mortality of acute pancreatitis
Issue Date2001
PublisherBlackwell Publishing Ltd.
Citation
Journal Of Viral Hepatitis, 2001, v. 8 n. 6, p. 459-464 How to Cite?
AbstractThe clinical outcome of acute pancreatitis complicating acute exacerbation of chronic hepatitis virus B (HBV) infection has never been studied. Ninety patients with acute pancreatitis were recruited. Five patients (5.6%) (Group 1) had acute pancreatitis superimposed on acute exacerbation of chronic HBV infection with no other causes of acute pancreatitis being identified. The clinical outcome of these five patients was compared to the 85 non-HBV infected patients (Group 2) with acute pancreatitis. A third group (Group 3) of patients (n=406) with acute exacerbation of chronic HBV infections without acute pancreatitis was also recruited for comparison. Group 1 had a significantly higher mortality rate (4 out of 5, 80%) compared to those of Group 2 (13 out of 85, 15.3%, P=0.0041) and Group 3 (9 out of 406, 2.2%, P<0.0001). In Group 1 patients, the acute pancreatitis occurred during the initial rise of HBV DNA with relatively low or normal level of alanine aminotransferase (ALT) in two patients, during the rise of ALT with declining level of HBV DNA in one patient, and during the cholestatic phase of the acute exacerbation in one patient. The acute pancreatitis was clinically silent and only diagnosed by computerized tomography in the remaining patient. Direct viral damage and/or immunological attack to the pancreatic tissue were probably the underlying pathogenesis of the acute pancreatitis in these patients. In conclusion, acute pancreatitis complicating acute exacerbation of chronic HBV infection carried an extremely poor prognosis with high mortality.
Persistent Identifierhttp://hdl.handle.net/10722/77347
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 1.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorHui, CKen_HK
dc.contributor.authorOnOn Chan, Aen_HK
dc.contributor.authorOiLin Ng, Ien_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:30:56Z-
dc.date.available2010-09-06T07:30:56Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Viral Hepatitis, 2001, v. 8 n. 6, p. 459-464en_HK
dc.identifier.issn1352-0504en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77347-
dc.description.abstractThe clinical outcome of acute pancreatitis complicating acute exacerbation of chronic hepatitis virus B (HBV) infection has never been studied. Ninety patients with acute pancreatitis were recruited. Five patients (5.6%) (Group 1) had acute pancreatitis superimposed on acute exacerbation of chronic HBV infection with no other causes of acute pancreatitis being identified. The clinical outcome of these five patients was compared to the 85 non-HBV infected patients (Group 2) with acute pancreatitis. A third group (Group 3) of patients (n=406) with acute exacerbation of chronic HBV infections without acute pancreatitis was also recruited for comparison. Group 1 had a significantly higher mortality rate (4 out of 5, 80%) compared to those of Group 2 (13 out of 85, 15.3%, P=0.0041) and Group 3 (9 out of 406, 2.2%, P<0.0001). In Group 1 patients, the acute pancreatitis occurred during the initial rise of HBV DNA with relatively low or normal level of alanine aminotransferase (ALT) in two patients, during the rise of ALT with declining level of HBV DNA in one patient, and during the cholestatic phase of the acute exacerbation in one patient. The acute pancreatitis was clinically silent and only diagnosed by computerized tomography in the remaining patient. Direct viral damage and/or immunological attack to the pancreatic tissue were probably the underlying pathogenesis of the acute pancreatitis in these patients. In conclusion, acute pancreatitis complicating acute exacerbation of chronic HBV infection carried an extremely poor prognosis with high mortality.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd.en_HK
dc.relation.ispartofJournal of Viral Hepatitisen_HK
dc.rightsJournal of Viral Hepatitis. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectComplications of HBV reactivationen_HK
dc.subjectExtrahepatic manifestation of HBVen_HK
dc.subjectHigh mortality of acute pancreatitisen_HK
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B, Chronic - complicationsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPancreatitis - diagnosis - etiologyen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.titleAcute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1352-0504&volume=8&spage=459&epage=464&date=2001&atitle=Acute+pancreatitis+complicating+acute+exacerbation+of+chronic+hepatitis+B+infection+carries+a+poor+prognosisen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailOiLin Ng, I:iolng@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityOiLin Ng, I=rp00335en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2893.2001.00315.xen_HK
dc.identifier.pmid11703578-
dc.identifier.scopuseid_2-s2.0-0035554347en_HK
dc.identifier.hkuros66018en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035554347&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue6en_HK
dc.identifier.spage459en_HK
dc.identifier.epage464en_HK
dc.identifier.isiWOS:000172342200010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridHui, CK=7202876933en_HK
dc.identifier.scopusauthoridOnOn Chan, A=6507629506en_HK
dc.identifier.scopusauthoridOiLin Ng, I=7102753722en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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