Name Card
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Professor Chan, Daniel Tak Mao 陳德茂

Title:
Chair Professor and Chief of Nephrology
Yu Chiu-Kwong Professorship in Medicine; and Professor: Chair of Medicine
Professor: Chair of Medicine
Professor (Clinical)
Yu Chiu-Kwong Professorship in Medicine

Contact Information
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Tel:
2255 4041
Office:

Professor Chan, Daniel Tak Mao 陳德茂

Title:
Chair Professor and Chief of Nephrology
Yu Chiu-Kwong Professorship in Medicine; and Professor: Chair of Medicine
Professor: Chair of Medicine
Professor (Clinical)
Yu Chiu-Kwong Professorship in Medicine

Curriculum Vitae:

Also Cited As:
Chan, TM
Chan, Tak-mao, Daniel

Biography

Professor Tak Mao Daniel Chan is currently Chair Professor, Yu Chiu Kwong Professor in Medicine, and Chief of Nephrology Division in the Department of Medicine at the University of Hong Kong and Hong Kong West Cluster Hospitals. He received his training in Nephrology and Internal Medicine at the University of Hong Kong and Guy’s Hospital, London, UK.

 

Research Profile

Prof Chan's research interests include:

  • clinical management of lupus nephritis

  • immuno-pathogenesis of lupus nephritis and chronic kidney diseases focusing on mechanisms leading to renal fibrosis

  • management of viral hepatitis in patients with chronic kidney disease

 

The team is internationally recognized for their clinical and translational research in lupus nephritis. Since the mid-1990s TM Chan’s team has published on clinical management regimens including the landmark paper in 2000 in the New England Journal of Medicine which led to establishment of mycophenolate as a new treatment paradigm for lupus nephritis. The team has also established the long-term safety and efficacy of mycophenolate as maintenance immunosuppression, and has investigated novel treatments including tacrolimus and mTOR inhibitors, with publications in J Am Soc Nephrol, Nature Rev Nephrol, Rheumatology, etc. TM Chan is the Lead Author for the Chapter on Lupus Nephritis in the latest version of KDIGO Clinical Management Guidelines for Glomerulonephritis, to be published in 2019/20.

The team’s translational and basic research focuses on immuno-pathogenesis of lupus nephritis and mechanisms leading to kidney fibrosis in chronic kidney disease due to lupus nephritis or other glomerular diseases. Their findings include the discovery that human anti-dsDNA antibodies could bind to glomerular mesangial cell membrane annexin II and get transported into the cytoplasmic and nuclear compartments leading to downstream cellular responses that contribute towards a pro-inflammatory and pro-fibrotic cellular phenotype. Their work using animal models examined the effects of novel treatments for lupus nephritis and mechanisms leading to kidney fibrosis and chronic kidney disease. The results have been published in J Am Soc Nephrol, Arthritis Rheum, Kidney Int, and other leading nephrology, rheumatology, or translational medicine journals.

TM Chan’s team was among the first in the early 1990s to describe the epidemiology and natural history of hepatitis C infection in dialysis patients and kidney transplant recipients, and is internationally recognized for their work in hepatitis B management in kidney transplant recipients. They were among the first to advocate preventive anti-viral treatment of kidney transplant patients at risk of hepatitis B reactivation, and they reported substantially improved patient survival with their clinical management strategy. The team has published their research output in leading journals including Hepatology, Gastroenterology, Transplantation, American Journal of Transplantation, and Transplant Infectious Disease. TM Chan is also an author for related chapters in UpToDate.

 

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Leung, JKH
Liu, ZH
Li, LS
2004-02-01Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells: 9th Medical Research Conference
Research Achievement
1998-12-01Asia Young Investigator Award
Research Achievement
2006-12-01Outstandind Researcher Award, University of Hong Kong
Research Achievement
Liu, ZH
Li, LS
2001-06-01Emodin ameliorates glucose-induced excess matrix synthesis by human peritoneal mesothelial cells: Peritoneal Dialysis International
Research Achievement
1995-12-01Sir Patrick Manson Gold Medal (MD thesis): The University of Hong Kong
Others
Tsang, RCW
Leung, JKH
2005-02-01Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity: 10th Medical Research Conference
Research Achievement
1997-12-01Award for Quality in Service & Management (on behalf of the Renal Unit): Queen Mary Hospital
Others
2008-12-01Professor R Yu Endowment Lecture 2008: Hong Kong Society of Nephrology
Research Achievement
1999-12-01Outstanding Young Researcher Award, 1999: University of Hong Kong
Research Achievement
2003-12-01Sir David Todd Lecture, 2003: Hong Kong College of Physicians
Research Achievement
2014-12-01高等學校科學研究優秀成果獎 (second in team listing, in collaboration with Central South University, Changsha, Hunan, 2014: 國家教育部
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
since 2004MemberHong Kong College of Physicians Examinations Committee
since 2003Executive Committee and Council MemberAsian Pacific Society of Nephrology
since 2000Executive Committee and Council MemberAsian Society of Transplantation
since 2000Programme Director and Board MemberHong Kong College of Physicians Advanced Internal Medicine Board
since 1996MemberHospital Authority Central Renal Committee
since 2002Honorary Secretary and Executive Committee MemberHKU Medical Alumni Association
since 2003MemberHospital Authority Training Subcommittee in Internal Medicine
since 1996Programme Director and Board MemberHong Kong College of Physicians Nephrology Board
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