Name Card
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Professor Chan, Daniel Tak Mao 陳德茂

Title:
Chair Professor and Chief of Nephrology
Yu Chiu-Kwong Professorship in Medicine; and Professor: Chair of Medicine
Professor (Clinical)
Professor: Chair of Medicine
Yu Chiu-Kwong Professorship in Medicine

Contact Information
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Tel:
2255 4041
Office:

Professor Chan, Daniel Tak Mao 陳德茂

Title:
Chair Professor and Chief of Nephrology
Yu Chiu-Kwong Professorship in Medicine; and Professor: Chair of Medicine
Professor (Clinical)
Professor: Chair of Medicine
Yu Chiu-Kwong Professorship in Medicine

Also Cited As:
Chan, TM
Chan, Tak-mao, Daniel

Biography

Professor Tak Mao Daniel Chan is currently Chair Professor, Yu Chiu Kwong Professor in Medicine and Chief of Nephrology Division in the Department of Medicine at the University of Hong Kong. He received his training in Nephrology and Internal Medicine at the University of Hong Kong and Guy’s Hospital, London, UK.

Research Profile

T M Chan’s research interests include:

  • treatment and immuno-pathogenesis of lupus nephritis
  • management of viral hepatitis in immunosuppressed patients with kidney diseases

The team is internationally recognized for their research output in lupus nephritis. In 2000 he published, in the New England Journal of Medicine, the first randomized controlled trial demonstrating the efficacy and tolerability of mycophenolate mofetil (MMF) in the treatment of severe lupus nephritis. Extended follow-up data from this investigator-initiated study was later published in the J Am Soc Nephrol (2005) and Rheumatology (Oxford) (2013). These results have subsequently been reconfirmed by other investigators and large-scale international multicenter studies, and MMF is now an established first-line standard of care treatment for lupus nephritis. The team has also investigated the potential of calcineurin inhibitors and proliferation signal inhibitors as novel treatments for lupus nephritis.  

Their basic research on lupus nephritis pathogenesis focuses on the interaction of anti-dsDNA antibodies with resident renal cells. They discovered that human anti-dsDNA antibodies could bind to annexin II on the surface of mesangial cells. After binding to the cell surface these autoantibodies are internalized and translocated to the cell nucleus, where they mediate downstream inflammatory and fibrotic responses. Translational work is being done to investigate the mechanisms and approaches to intervene progressive renal fibrosis following active lupus nephritis. The results have been published in J Am Soc Nephrol, Arthritis Rheum, and Kidney Int.

The team was among the first in the early 1990s to describe the epidemiology and natural history of hepatitis C infection in dialysis patients and kidney transplant recipients, and is internationally recognized for their work in hepatitis B management in kidney transplant recipients. They showed that pre-emptive antiviral treatment markedly improved the survival of HBsAg+ kidney transplant recipients, and investigated the role of novel antiviral medications. These results have been published in Gastroenterology, Hepatology, Am J Transplant, and Transplantation. He is also an author for related chapters in UpToDate.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Leung, JKH
Liu, ZH
Li, LS
2004-02-01Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells: 9th Medical Research Conference
Research Achievement
1998-12-01Asia Young Investigator Award
Research Achievement
2006-12-01Outstandind Researcher Award, University of Hong Kong
Research Achievement
Liu, ZH
Li, LS
2001-06-01Emodin ameliorates glucose-induced excess matrix synthesis by human peritoneal mesothelial cells: Peritoneal Dialysis International
Research Achievement
1995-12-01Sir Patrick Manson Gold Medal (MD thesis): The University of Hong Kong
Others
Tsang, RCW
Leung, JKH
2005-02-01Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity: 10th Medical Research Conference
Research Achievement
1997-12-01Award for Quality in Service & Management (on behalf of the Renal Unit): Queen Mary Hospital
Others
Professional Societies
Term PeriodPositionProfessional Societies
since 2004MemberHong Kong College of Physicians Examinations Committee
since 2003Executive Committee and Council MemberAsian Pacific Society of Nephrology
since 2000Executive Committee and Council MemberAsian Society of Transplantation
since 2000Programme Director and Board MemberHong Kong College of Physicians Advanced Internal Medicine Board
since 1996MemberHospital Authority Central Renal Committee
since 2002Honorary Secretary and Executive Committee MemberHKU Medical Alumni Association
since 2003MemberHospital Authority Training Subcommittee in Internal Medicine
since 1996Programme Director and Board MemberHong Kong College of Physicians Nephrology Board
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