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Patent History
- ApplicationUS 11/883661 2006-02-01
- PublicationUS 2008319184 2008-12-25
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published patent: Uses of Dinucleotide Polyphosphate Derivatives
Title | Uses of Dinucleotide Polyphosphate Derivatives |
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Priority Date | 2005-02-03 GB20050002250 2006-02-01 PCT/GB2006000343 |
Inventors | |
Issue Date | 2008 |
Citation | US Published patent application US 2008319184. Washington, DC: US Patent and Trademark Office (USPTO), 2008 How to Cite? |
Abstract | The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX3X4-,-NH-,-O-; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6. |
Persistent Identifier | http://hdl.handle.net/10722/176971 |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:52Z | - |
dc.date.available | 2012-11-30T08:38:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | US Published patent application US 2008319184. Washington, DC: US Patent and Trademark Office (USPTO), 2008 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176971 | - |
dc.description.abstract | The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX3X4-,-NH-,-O-; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6. | en_HK |
dc.title | Uses of Dinucleotide Polyphosphate Derivatives | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.hkuros | 178696 | - |
dc.identifier.hkuros | 178698 | - |
dc.contributor.inventor | Miller Andrew David | en_HK |
dc.contributor.inventor | Wright Michael | en_HK |
dc.contributor.inventor | Tanner, JA | en_HK |
dc.contributor.inventor | Lozovaya Natalya | en_HK |
patents.identifier.application | US 11/883661 | en_HK |
patents.description.country | United States of America | en_HK |
patents.date.publication | 2008-12-25 | en_HK |
patents.date.application | 2006-02-01 | en_HK |
patents.date.priority | 2005-02-03 GB20050002250 | en_HK |
patents.date.priority | 2006-02-01 PCT/GB2006000343 | en_HK |
patents.description.cc | US | en_HK |
patents.identifier.publication | US 2008319184 | en_HK |
patents.relation.family | AU 2006210715 (A1) 2006-08-10 | en_HK |
patents.relation.family | CA 2596959 (A1) 2006-08-10 | en_HK |
patents.relation.family | CN 101180066 (A) 2008-05-14 | en_HK |
patents.relation.family | EP 1846004 (A1) 2007-10-24 | en_HK |
patents.relation.family | JP 2008528665 (A) 2008-07-31 | en_HK |
patents.relation.family | US 2008319184 (A1) 2008-12-25 | en_HK |
patents.relation.family | WO 2006082397 (A1) 2006-08-10 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |