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  Patent History
  • Application
    US 11/883661 2006-02-01
  • Publication
    US 2008319184 2008-12-25
Supplementary

published patent: Uses of Dinucleotide Polyphosphate Derivatives

TitleUses of Dinucleotide Polyphosphate Derivatives
Priority Date2005-02-03 GB20050002250
2006-02-01 PCT/GB2006000343
Inventors
Issue Date2008
Citation
US Published patent application US 2008319184. Washington, DC: US Patent and Trademark Office (USPTO), 2008 How to Cite?
AbstractThe present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX3X4-,-NH-,-O-; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6.
Persistent Identifierhttp://hdl.handle.net/10722/176971

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:52Z-
dc.date.available2012-11-30T08:38:52Z-
dc.date.issued2008-
dc.identifier.citationUS Published patent application US 2008319184. Washington, DC: US Patent and Trademark Office (USPTO), 2008en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176971-
dc.description.abstractThe present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX3X4-,-NH-,-O-; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleUses of Dinucleotide Polyphosphate Derivativesen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.hkuros178696-
dc.identifier.hkuros178698-
dc.contributor.inventorMiller Andrew Daviden_HK
dc.contributor.inventorWright Michaelen_HK
dc.contributor.inventorTanner, JAen_HK
dc.contributor.inventorLozovaya Natalyaen_HK
patents.identifier.applicationUS 11/883661en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2008-12-25en_HK
patents.date.application2006-02-01en_HK
patents.date.priority2005-02-03 GB20050002250en_HK
patents.date.priority2006-02-01 PCT/GB2006000343en_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2008319184en_HK
patents.relation.familyAU 2006210715 (A1) 2006-08-10en_HK
patents.relation.familyCA 2596959 (A1) 2006-08-10en_HK
patents.relation.familyCN 101180066 (A) 2008-05-14en_HK
patents.relation.familyEP 1846004 (A1) 2007-10-24en_HK
patents.relation.familyJP 2008528665 (A) 2008-07-31en_HK
patents.relation.familyUS 2008319184 (A1) 2008-12-25en_HK
patents.relation.familyWO 2006082397 (A1) 2006-08-10en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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