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  Patent History
  • Application
    CN 20048039355 2004-12-06
  • Publication
    CN 1906302 2007-01-31

published patent: Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS

TitleGenetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS
Priority Date2004-12-06 PCT/CN2004001419
2003-12-05 US 10/527637P
Inventors
Issue Date2007
Citation
China Published Patent Application CN 1906302. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2007 How to Cite?
AbstractThe invention relates to genetically modified plants and progeny thereof which constitute edible plant-derived mucosal vaccines and injectable plant-derived mucosal vaccines against Severe Acute Respiratory Syndrome (SARS). The invention relates to a recombinant vector that transforms specifically, but not limited to, the nuclei and/or plastids of tobacco, tomato and lettuce plants for antigen production. In specific embodiments, the plastid transformation vector expressing the nucleotide sequences are pCV1, pCV6 and pCV8, and their derivatives containing an S1 with nucleotide (but not amino acid) changes to optimize codon usage for expression in plants.; The present invention relates to methods of making the modified plants which comprises transformation of plants with vectors for nuclearexpression and/or plastid expression of nucleotide sequences of the SARS-CoV virus, fragments, derivatives, analogs, or variants thereof. The present invention also relates to methods of immunizationagainst SARS and methods of antibody detection using the SARS-CoV antigens generated by the plastid and/or nuclear vector(s) transformed plants.
Persistent Identifierhttp://hdl.handle.net/10722/176689

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:21Z-
dc.date.available2012-11-30T08:38:21Z-
dc.date.issued2007-
dc.identifier.citationChina Published Patent Application CN 1906302. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2007en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176689-
dc.description.abstractThe invention relates to genetically modified plants and progeny thereof which constitute edible plant-derived mucosal vaccines and injectable plant-derived mucosal vaccines against Severe Acute Respiratory Syndrome (SARS). The invention relates to a recombinant vector that transforms specifically, but not limited to, the nuclei and/or plastids of tobacco, tomato and lettuce plants for antigen production. In specific embodiments, the plastid transformation vector expressing the nucleotide sequences are pCV1, pCV6 and pCV8, and their derivatives containing an S1 with nucleotide (but not amino acid) changes to optimize codon usage for expression in plants.; The present invention relates to methods of making the modified plants which comprises transformation of plants with vectors for nuclearexpression and/or plastid expression of nucleotide sequences of the SARS-CoV virus, fragments, derivatives, analogs, or variants thereof. The present invention also relates to methods of immunizationagainst SARS and methods of antibody detection using the SARS-CoV antigens generated by the plastid and/or nuclear vector(s) transformed plants.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleGenetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorChye, MLen_HK
dc.contributor.inventorLi Hong Yen_HK
dc.contributor.inventorRamalingam Sathiskumaren_HK
dc.contributor.inventorPeiris, JSMen_HK
dc.contributor.inventorPoon, LLMen_HK
patents.identifier.applicationCN 20048039355en_HK
patents.description.assigneeUNIV HONG KONG [HK]en_HK
patents.description.countryChina, PRCen_HK
patents.date.publication2007-01-31en_HK
patents.date.application2004-12-06en_HK
patents.date.priority2004-12-06 PCT/CN2004001419en_HK
patents.date.priority2003-12-05 US 10/527637Pen_HK
patents.description.ccCNen_HK
patents.identifier.publicationCN 1906302en_HK
patents.relation.familyCN 1906302 (A) 2007-01-31en_HK
patents.relation.familyUS 2006053516 (A1) 2006-03-09en_HK
patents.relation.familyWO 2005054473 (A1) 2005-06-16en_HK
patents.description.kindAen_HK
patents.typePatent_publisheden_HK

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