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  Patent History
  • Application
    PC T/CN2004001419 2004-12-06
  • Publication
    WO 2005054473 2005-06-16

published patent: GENETICALLY MODIFIED PLANTS COMPRISING SARS-CoV VIRAL NUCLEOTIDE SEQUENCES AND METHODS OF USE THEREOF FOR IMMUNIZATION AGAINST SARS

TitleGENETICALLY MODIFIED PLANTS COMPRISING SARS-CoV VIRAL NUCLEOTIDE SEQUENCES AND METHODS OF USE THEREOF FOR IMMUNIZATION AGAINST SARS
Priority Date2003-12-05 US 10/527637P
Inventors
Issue Date2005
Citation
WO Published patent application WO 2005054473. World Intellectual Property Organization (WIPO), PatentScope, 2005 How to Cite?
AbstractThe invention relates to genetically modified plants and progeny thereof which constitute edible plant-derived mucosal vaccines and injectable plant-derived mucosal vaccines against Severe Acute Respiratory Syndrome (SARS). The invention relates to a recombinant vector that transforms specifically, but not limited to, the nuclei and/or plastids of tobacco, tomato and lettuce plants for antigen production. In specific embodiments, the plastid transformation vector expressing the nucleotide sequences are pCV1, pCV6 and pCV8, and their derivatives containing an S1 with nucleotide (but not amino acid) changes to optimize codon usage for expression in plants. The present invention relates to methods of making the modified plants which comprises transformation of plants with vectors for nuclear expression and/or plastid expression of nucleotide sequences of the SARS-CoV virus, fragments, derivatives, analogs, or variants thereof. The present invention also relates to methods of immunization against SARS and methods of antibody detection using the SARS-CoV antigens generated by the plastid and/or nuclear vector(s) transformed plants.
Persistent Identifierhttp://hdl.handle.net/10722/177098
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:07Z-
dc.date.available2012-11-30T08:39:07Z-
dc.date.issued2005-
dc.identifier.citationWO Published patent application WO 2005054473. World Intellectual Property Organization (WIPO), PatentScope, 2005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177098-
dc.description.abstractThe invention relates to genetically modified plants and progeny thereof which constitute edible plant-derived mucosal vaccines and injectable plant-derived mucosal vaccines against Severe Acute Respiratory Syndrome (SARS). The invention relates to a recombinant vector that transforms specifically, but not limited to, the nuclei and/or plastids of tobacco, tomato and lettuce plants for antigen production. In specific embodiments, the plastid transformation vector expressing the nucleotide sequences are pCV1, pCV6 and pCV8, and their derivatives containing an S1 with nucleotide (but not amino acid) changes to optimize codon usage for expression in plants. The present invention relates to methods of making the modified plants which comprises transformation of plants with vectors for nuclear expression and/or plastid expression of nucleotide sequences of the SARS-CoV virus, fragments, derivatives, analogs, or variants thereof. The present invention also relates to methods of immunization against SARS and methods of antibody detection using the SARS-CoV antigens generated by the plastid and/or nuclear vector(s) transformed plants.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleGENETICALLY MODIFIED PLANTS COMPRISING SARS-CoV VIRAL NUCLEOTIDE SEQUENCES AND METHODS OF USE THEREOF FOR IMMUNIZATION AGAINST SARSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChye, MLen_HK
dc.contributor.inventorLi, Hongyeen_HK
dc.contributor.inventorSathishkumar, Ramalingamen_HK
dc.contributor.inventorPoon, LLMen_HK
dc.contributor.inventorPeiris, JSM-
patents.identifier.applicationPC T/CN2004001419en_HK
patents.description.assigneeUNIV HONG KONG [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2005-06-16en_HK
dc.relation.referencesCN 1450173 (A) 2003-10-22en_HK
dc.relation.referencesCN 1449826 (A) 2003-10-22en_HK
dc.relation.referencesCN 1548452 (A) 2004-11-24en_HK
dc.relation.referencesXP 002288827en_HK
patents.date.application2004-12-06en_HK
patents.date.priority2003-12-05 US 10/527637Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2005054473en_HK
patents.relation.familyCN 1906302 (A) 2007-01-31en_HK
patents.relation.familyUS 2006053516 (A1) 2006-03-09en_HK
patents.relation.familyWO 2005054473 (A1) 2005-06-16en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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