published patent: ORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION

TitleORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION
Priority Date2003-02-28 PCT/CN2003000160
2002-02-28 US 10/359945P
Inventors
Issue Date2003
Citation
Australia Published Patent Application AU 2003210122. Australia: IP Australia, 2003 How to Cite?
AbstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) and for suppressing transgene expression for a protrated period of time comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestinal mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Given orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene(s) in the eurokaryotic environment, the viral products of which help to booster a cell-mediated immunity to clear the infection and reverse a state of immune tolerance characteristic of HBV chronic infection.
Persistent Identifierhttp://hdl.handle.net/10722/176532

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:05Z-
dc.date.available2012-11-30T08:38:05Z-
dc.date.issued2003-
dc.identifier.citationAustralia Published Patent Application AU 2003210122. Australia: IP Australia, 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176532-
dc.description.abstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) and for suppressing transgene expression for a protrated period of time comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestinal mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Given orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene(s) in the eurokaryotic environment, the viral products of which help to booster a cell-mediated immunity to clear the infection and reverse a state of immune tolerance characteristic of HBV chronic infection.en_HK
dc.titleORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorMunhon Ngen_HK
dc.contributor.inventorYuen, KYen_HK
dc.contributor.inventorBojian Zhengen_HK
patents.identifier.applicationAU 20030210122en_HK
patents.description.assigneeUNIV HONG KONGen_HK
patents.description.countryAustraliaen_HK
patents.date.publication2003-09-09en_HK
patents.date.application2003-02-28en_HK
patents.date.priority2003-02-28 PCT/CN2003000160en_HK
patents.date.priority2002-02-28 US 10/359945Pen_HK
patents.description.ccAUen_HK
patents.identifier.publicationAU 2003210122en_HK
patents.relation.familyAU 2003210122 (A1) 2003-09-09en_HK
patents.relation.familyCA 2380471 (A1) 2003-08-28en_HK
patents.relation.familyCN 1444996 (A) 2003-10-01en_HK
patents.relation.familyCN 100528238 (C) 2009-08-19en_HK
patents.relation.familyHK 1058144 (A1) 2010-04-23en_HK
patents.relation.familyUS 2003162741 (A1) 2003-08-28en_HK
patents.relation.familyUS 2006228374 (A1) 2006-10-12en_HK
patents.relation.familyWO 03072012 (A2) 2003-09-04en_HK
patents.description.kindA8en_HK
patents.typePatent_publisheden_HK

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