published patent: ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION

TitleORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION
Priority Date2002-02-28 US 10/359945P
Inventors
Issue Date2003
Citation
Canada Published Patent Application CA 2380471. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2003 How to Cite?
AbstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestin al mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Giv en orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene( s) in the eurokaryotic environment, the viral products of which help to booster a cell - mediated immunity to clear the infection and reverse a state of immune tolerance characteristi c of HBV chronic infection.
Persistent Identifierhttp://hdl.handle.net/10722/176574

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:08Z-
dc.date.available2012-11-30T08:38:08Z-
dc.date.issued2003-
dc.identifier.citationCanada Published Patent Application CA 2380471. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176574-
dc.description.abstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestin al mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Giv en orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene( s) in the eurokaryotic environment, the viral products of which help to booster a cell - mediated immunity to clear the infection and reverse a state of immune tolerance characteristi c of HBV chronic infection.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorYuen, KYen_HK
dc.contributor.inventorZheng, Ben_HK
dc.contributor.inventorNg, Mun-Honen_HK
patents.identifier.applicationCA 20022380471en_HK
patents.description.assigneeUNIV HONG KONG [HK]en_HK
patents.description.countryCanadaen_HK
patents.date.publication2003-08-28en_HK
patents.date.application2002-03-27en_HK
patents.date.priority2002-02-28 US 10/359945Pen_HK
patents.description.ccCAen_HK
patents.identifier.publicationCA 2380471en_HK
patents.relation.familyAU 2003210122 (A1) 2003-09-09en_HK
patents.relation.familyCA 2380471 (A1) 2003-08-28en_HK
patents.relation.familyCN 1444996 (A) 2003-10-01en_HK
patents.relation.familyCN 100528238 (C) 2009-08-19en_HK
patents.relation.familyHK 1058144 (A1) 2010-04-23en_HK
patents.relation.familyUS 2003162741 (A1) 2003-08-28en_HK
patents.relation.familyUS 2006228374 (A1) 2006-10-12en_HK
patents.relation.familyWO 03072012 (A2) 2003-09-04en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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