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  Patent History
  • Application
    HK 20040100585 2004-01-28
  • Publication
    HK 1058144 2010-04-23
Supplementary

published patent: ORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION

TitleORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION
Priority Date2002-02-28 US 10/359945P
Inventors
Issue Date2010
Citation
Hong Kong Published Patent Application HK 1058144. Hong Kong, PRC: Intellectual Property Office of the Governmemnt of the Hong Kong Special Administration Region, 2010 How to Cite?
AbstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) and for suppressing transgene expression for a protrated period of time comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestinal mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Given orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene(s) in the eurokaryotic environment, the viral products of which help to booster a cell-mediated immunity to clear the infection and reverse a state of immune tolerance characteristic of HBV chronic infection.
Persistent Identifierhttp://hdl.handle.net/10722/176780

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:28Z-
dc.date.available2012-11-30T08:38:28Z-
dc.date.issued2010-
dc.identifier.citationHong Kong Published Patent Application HK 1058144. Hong Kong, PRC: Intellectual Property Office of the Governmemnt of the Hong Kong Special Administration Region, 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176780-
dc.description.abstractThe present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) and for suppressing transgene expression for a protrated period of time comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestinal mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Given orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene(s) in the eurokaryotic environment, the viral products of which help to booster a cell-mediated immunity to clear the infection and reverse a state of immune tolerance characteristic of HBV chronic infection.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleORAL DNA COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTIONen_HK
dc.typePatenten_US
dc.contributor.inventorMun-Hon Ngen_HK
dc.contributor.inventorYuen, KYen_HK
dc.contributor.inventorZheng, Ben_HK
patents.identifier.applicationHK 20040100585en_HK
patents.description.assigneeUNIV HONG KONG G18 ELIOT HALL [HK]en_HK
patents.description.countryHong Kong (S.A.R.)en_HK
patents.date.publication2010-04-23en_HK
patents.date.application2004-01-28en_HK
patents.date.priority2002-02-28 US 10/359945Pen_HK
patents.description.ccHKen_HK
patents.identifier.publicationHK 1058144en_HK
patents.relation.familyAU 2003210122 (A1) 2003-09-09en_HK
patents.relation.familyCA 2380471 (A1) 2003-08-28en_HK
patents.relation.familyCN 1444996 (A) 2003-10-01en_HK
patents.relation.familyCN 100528238 (C) 2009-08-19en_HK
patents.relation.familyHK 1058144 (A1) 2010-04-23en_HK
patents.relation.familyUS 2003162741 (A1) 2003-08-28en_HK
patents.relation.familyUS 2006228374 (A1) 2006-10-12en_HK
patents.relation.familyWO 03072012 (A2) 2003-09-04en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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