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Article: PIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

TitlePIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma
Other TitlesPIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma
Authors
Keywordsβ-catenin
Hepatocellular carcinoma
Peptidyl-prolyl-isomerase
PIN1
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 2004, v. 23 n. 23, p. 4182-4186 How to Cite?
AbstractThe peptidyl-proplyl-isomerase, PIN1, upregulates β-catenin by inhibiting its interaction with APC. β-catenin accumulation occurs in about 70% of hepatocellular carcinoma (HCC), of which only 20% are due to β-catenin mutations. The role of PIN1 in β-catenin upregulation in HCC was investigated. PIN1 was shown to be overexpressed in more than 50% of HCC. All cases with PIN1 overexpression also showed β-catenin accumulation, with 68% of cases showing concomitant β-catenin and cyclin D1 accumnlation. PIN1 was shown to contribute to β-catenin and cyclin D1 overexpression directly by in vitro cell-line transfection experiments. Finally, we showed that PIN1 overexpression and β-catenin gene mutations appeared to be mutually exclusive events, leading to β-catenin accumulation in HCC. These results showed that PIN1 overexpression leading to β-catenin accumulation might be a critical event in hepatocarcinogenesis, and that PIN1 is a potential target for therapeutic intervention in HCC.
Persistent Identifierhttp://hdl.handle.net/10722/148438
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, Ren_HK
dc.contributor.authorYuen, Jen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLee, TKWen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorTse, Een_HK
dc.date.accessioned2012-05-29T06:12:58Z-
dc.date.available2012-05-29T06:12:58Z-
dc.date.issued2004en_HK
dc.identifier.citationOncogene, 2004, v. 23 n. 23, p. 4182-4186en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148438-
dc.description.abstractThe peptidyl-proplyl-isomerase, PIN1, upregulates β-catenin by inhibiting its interaction with APC. β-catenin accumulation occurs in about 70% of hepatocellular carcinoma (HCC), of which only 20% are due to β-catenin mutations. The role of PIN1 in β-catenin upregulation in HCC was investigated. PIN1 was shown to be overexpressed in more than 50% of HCC. All cases with PIN1 overexpression also showed β-catenin accumulation, with 68% of cases showing concomitant β-catenin and cyclin D1 accumnlation. PIN1 was shown to contribute to β-catenin and cyclin D1 overexpression directly by in vitro cell-line transfection experiments. Finally, we showed that PIN1 overexpression and β-catenin gene mutations appeared to be mutually exclusive events, leading to β-catenin accumulation in HCC. These results showed that PIN1 overexpression leading to β-catenin accumulation might be a critical event in hepatocarcinogenesis, and that PIN1 is a potential target for therapeutic intervention in HCC.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectβ-cateninen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectPeptidyl-prolyl-isomeraseen_HK
dc.subjectPIN1en_HK
dc.subject.meshCarcinoma, Hepatocellular - Etiology - Genetics - Metabolismen_US
dc.subject.meshCyclin D1 - Biosynthesis - Geneticsen_US
dc.subject.meshCytoskeletal Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshPeptidylprolyl Isomerase - Biosynthesis - Geneticsen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTrans-Activators - Geneticsen_US
dc.subject.meshTransfectionen_US
dc.subject.meshBeta Cateninen_US
dc.titlePIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinomaen_HK
dc.title.alternativePIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma-
dc.typeArticleen_HK
dc.identifier.emailPang, R: robertap@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailLee, TKW: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.emailTse, E: ewctse@hku.hken_HK
dc.identifier.authorityPang, R=rp00274en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityLee, TKW=rp00447en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.onc.1207493en_HK
dc.identifier.pmid15064734-
dc.identifier.scopuseid_2-s2.0-2942588392en_HK
dc.identifier.hkuros87912-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942588392&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue23en_HK
dc.identifier.spage4182en_HK
dc.identifier.epage4186en_HK
dc.identifier.isiWOS:000221520200018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPang, R=7004376659en_HK
dc.identifier.scopusauthoridYuen, J=7102620480en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLee, TKW=7501439435en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, CM=16314668400en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridTse, E=7005019454en_HK
dc.customcontrol.immutablesml 130620-

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