Name Card
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Professor Leung, Suet Yi 梁雪兒

Title:
Associate Dean (Research), Li Ka Shing Faculty of Medicine
Associate Dean, Li Ka Shing Faculty of Medicine
Y M Kan Professorship in Natural Sciences
Professor, Chair of Gastrointestinal Cancer Genetics and Genomics
Clinical Professor

Contact Information
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Professor Leung, Suet Yi 梁雪兒

Title:
Associate Dean (Research), Li Ka Shing Faculty of Medicine
Associate Dean, Li Ka Shing Faculty of Medicine
Y M Kan Professorship in Natural Sciences
Professor, Chair of Gastrointestinal Cancer Genetics and Genomics
Clinical Professor

Research Interests:(click to check for cognate researchers)

Also Cited As:
Leung, Suet-yi
Leung, SY

Professional Qualifications
YearAwarding InstitutionQualification
The Royal College of Pathologists of AustralasiaFRCPA
The Hong Kong Academy of MedicineFHKAM (Pathology)
Hong Kong Academy of MedicineFHKCPath
The Royal College of PathologistsFRCPath (UK)
The Royal College of Pathologists of AustralasiaFaculty of Science Founding Fellow
The University of Hong KongMD
Biography

My research interests are focused on the molecular genetics and genomics of gastric and colorectal cancers. We have performed genomics studies on large series of gastric and colorectal cancers using next-generation sequencing, expression microarray and DNA SNP chip. Our study revealed the genomic landscape of gastric cancer and first identified frequent mutation of ARID1A, a chromatic remodeling gene, in gastric cancer. Our study of gene expression have revealed novel modules reflecting intrinsic properties of tumour and normal cells, tumour-stroma interaction, host immune response and pathways of stem cell regulation. This information have led to the identification of new tumour suppressor genes frequently silenced in gastrointestinal cancers, genes that can modify tumour aggressive behaviour and patient outcome, and genes that contribute to maintenance of stem cell niche.

Our team has extensively characterized the genetic basis for the exceptionally high incidence of early-onset colorectal cancer (CRC) in Hong Kong. We have uncovered the mutation spectrum of germline DNA mismatch repair gene, and revealed a founder mutation that is common in the Southern Chinese population which originated between 22 and 103 generations ago. We have described the first example of heritable germline methylation of MSH2 gene promoter as a cause of hereditary colon cancer, and uncovered a novel mechanism of methylation induction and gene silencing through abrogation of transcriptional termination signal in an upstream neighbouring gene named EPCAM (TACSTD1). These findings have resulted in incorporation of EPCAM deletion into the standard genetic diagnosis protocol for Lynch Syndrome worldwide. Our laboratory is now applying the research findings to patient care, by providing a charitable genetic diagnosis service including genetic testing and referral for prophylactic screening for early-onset or familial colorectal cancer patients and their families. We have also studied in depth the role of the BRAF mutation in colorectal cancers, and discovered an interesting relationship between the BRAF mutation and various pathways of colorectal carcinogenesis.

The long term goal of our laboratory is to utilise genomics technology to identify novel pathways of carcinogenesis and hereditary predisposition for colorectal and gastric cancers, and to identify biomarkers for early detection, patient stratification, prognostication or drug targets.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Ligtenberg, MJ
Kuiper, RP
Goossens, M
Hebeda, KM
Voorendt, M
Lee, TYH
Bodmer, D
Hoenselaar, E
Hendriks-Cornelissen, SJ
Tsui, WY
Kong, CK
Brunner, HG
van Kessel, AG
Yuen, ST
van Krieken, JH
Hoogerbrugge, N
2009-01-01Research Output Prize "Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nature Genetics. 2009, 41(1): 112-7": The University of Hong Kong
Research Achievement
2008-01-01Outstanding Researcher Award: The University of Hong Kong
Research Achievement
2012-04-20Y W Kan Professorship in Natural Sciences: The University of Hong Kong
Others
Yuen, ST
Kong, CK
Chan, YW
Chan, ASY
Ng, WF
Tsui, WY
Lo, MWS
Tam, WY
Li, VSW
2007-10-01Research Output Prize "Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer, Nature Genetics. 2006, 38(10): 1178-83": The University of Hong Kong
Research Achievement
Wang, K
Kan, J
Yuen, ST
Shi, ST
Kan, Z
Chan, ASY
Tsui, WY
Lee, SP
Ho, RSL
Chan, KW
Cheng, HWG
Roberts, PC
Rejto, PA
Gibson, NW
Pocalyko, DJ
Mao, M
Xu, J
2012-06-29Faculty Outstanding Research Output Award "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer", Nat Genet. 2011: Li Ka Shing Faculty of Medicine, The University of Hong Kong
Research Achievement
2001-05-01Outstanding Young Researcher Award: The University Of Hong Kong
Research Achievement
2007-03-01Croucher Senior Medical Research Fellowship: The Croucher Foundation
Research Achievement
2014-09-01Outstanding Women Professionals Award 2014: Hong Kong Women Professional & Entrepreneurs Association
Others
Professional Societies
Term PeriodPositionProfessional Societies
01/1994 - PresentMemberThe American Association of Neuropathologists
2011 - PresentMemberMutation Interpretation Committee of the International Society for Gastrointestinal Hereditary Tumours (InSIGHT)
01/2000 - 12/2001ExaminerThe Hong Kong College of Pathologists
01/2001 - 12/2010Laboratory InspectorThe Hong Kong College of Pathologists
1995 - PresentFounding memberThe Hong Kong Society of Neuropathologists
01/1999 - PresentCouncil MemberCentre of Alimentary Research and Education, HKU
01/1996 - PresentMemberThe American Association for Cancer Research
1993 - PresentMemberThe International Academy of Pathology
Media Contact Directory
Spoken Languages:
Spoken Language(s) (EN)Spoken Language(s) (ZH)
English, Cantonese英語、粵語
Written Languages:
Written Language(s) (EN)Written Language(s) (ZH)
English, Chinese英文、中文
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