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Name Card
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Professor Irene Ng 吳呂愛蓮

Title:
Professor, Chair of Pathology
Director, State Key Laboratory of Liver Research (HKU)

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
17111315The role of SUMO-specific protease SENP1 in liver cancer11988782015
 
HKU 7329/02MDysregulation of NF-[kappa]B signaling in liver cancer14440002002
 
HKU 7436/04MFunctional characterization of DLC1 gene, a novel tumour suppressor gene frequently deleted in liver cancer19868802004
 
05050022Characterization of the roles of hepatitis B virus X protein in liver cancer8000002005
 
HKU 7281/01MIdentification and characterization of DLC-2, a candidate tumour suppressor gene on 13q frequently deleted in liver cancer9540002001
 
N_HKU 716/06Characterization of regulatory molecules of Wnt/beta-catenin signaling in liver cancer7307002006
 
HKU 775110MSignificance of cten dysregulation in hepatocarcinogenesis and cancer metastasis10320002010
 
HKU 7615/06MSignificance of LRP6 coreceptor upregulation in the aberrant activation of Wnt signaling in liver cancer18305002006
 
N/AStudy of DNA ploidy and tumour suppressor genes and their significance in relation to the prognosis and causation of hepatocellular carcinoma4934921990
 
HKU 775811MSignificance of RhoE dysregulation in liver cancer and metastasis16059952011
 
InP/142/11The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer1318802011
 
ITS/096/11The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer9999482011
 
HKU 7342/00MDetection of genetic alterations on chromosome 8 in liver cancer by high-throughput fluorescent in-situ hybridization on tissue microarrays and by deletion mapping7632002000
 
N/AMolecular science of liver diseases: linking basic science to clinical application5310002001
 
N_HKU 717/02Functional characterization of novel genes in liver cancer7991262002
 
N/AMolecular genetics and cell signaling in cancers6000002004
 
N/ACharacterization of DLC1 gene, a novel tumour suppressor gene frequently deleted in liver cancer15103712004
 
N/AGenome-wide methylation screening in search for novel tumour suppressor genes in liver cancer15153712004
 
HKU 7454/03MDeciphering dysregulation of mitotic checkpoint control in liver cancer16530002003
 
N/ADetection and localization of hepatitis C virus in tissues of hepatocellular carcinoma and chronic liver diseases200001992
 
N/AA study of molecular mechanisms and characterizing novel genes in liver cancer6707202005
 
HKU 1/06CMolecular pathology of liver cancer - a multidisciplinary study64000002006
 
HKU 772608MRole of mitotic checkpoint gene MAD1 (mitotic arrest deficient 1) in liver cancer10200472008
 
HKU 7/CRF/09Molecular Pathology of Liver Cancer - a Multidisciplinary Study81000002009
 
InP/153/11The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer1183672011
 
N/ACancer Biology18000002012
 
12111092Dissecting the gender disparity of hepatocellular carcinoma: Roles of HBV X protein and androgen receptor6040002012
 
HKU 775513MThe role of Lgr5 in liver cancer9526362013
 
17116414Delineation of the role of RPS6KA3, which encodes p90 ribosomal S6 kinase 2 (RPS6KA3), and their natural mutants in liver cancer6184082014
 
N/ALiver cancer research - From bench to translational applications10320002013
 
T12-716/22-R Delineating and translating the mechanistic determinants to improve the clinical management of liver cancer332685562022
 
N/AStudy on the pathogenesis of SARS coronavirus by establishing transgenic mouse lines expressing SARS-CoV viral proteins500002003
 
12133191Characterization of functions of RhoE/ROCK pathway in regulating chemoresistance of liver cancer6090002014
 
03142966Characterization of anti-CCL28 as a novel therapy to overcome sorafenib resistance in HCC11732962015
 
17141416The role of RalA GTPase and its regulator RalGAP in liver cancer8864202016
 
06172886The functional significance of RalA: regulations and therapeutic implication in liver cancer14910402018
 
04152336A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment11999002016
 
T12-704/16-RUnderstanding Cancer Stemness in Liver Cancer – From Regulation to Translational Applications285234002016
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
81872222Elucidation of frequent TERT HBV integration and telomerase reactivation in HBV-associated hepatocellular carcinoma7159202018
 
C7018-14EMicro-PET for pre-clinical molecular imaging research in Hong Kong80014862014
 
N/ATreatment of unresectable hepatocellular carcinoma with arterial chemoembolisation: a randomised controlled trial01996
 
ITS/114/12Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD479936782012
 
HKU 778508MRoles of histone methyltransferases SUV39H1 and SUV39H2 in liver cancer8975782008
 
ITS/112/02Development of novel nucleic acid therapeutics for viral infection and cancer23134722002
 
01121436Statistical method to identify risk genes of complex diseases based on functional gene sets and networks, with a genetic data mining application to hepatocellular carcinoma9999902013
 
17153116Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development8830352016
 
04150776Characterization of a novel tumor suppressive long non-coding RNA linc-ALDH1A2-1 in hepatocellular carcinoma11999562016
 
05161786Pathological significances and therapeutic potential of targeting FACT complex in liver cancer11300482017
 
HKU 7560/06MGEP as a novel molecular target for liver cancer therapy6545002006
 
N/ATumour Microenvironment - New concepts and molecular mechanisms6000002010
 
02132696Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development9997802014
 
17100021Elucidation of the immunosuppressive landscape and subclonal heterogeneity in hepatocellular carcinoma by single-cell RNA sequencing8997322021
 
17117015The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer11683312015
 
04150856Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer9628562016
 
HKU 763607MFunctional characterization of a putative tumour suppressor, AMP-activated protein kinase, in liver cancer10857292007
 
03142986Deregulation and somatic mutations of histone methyltransferase ASH1L in liver cancer.11696082015
 
81272440The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma8792002012
 
17115218Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma.9720002018
 
HKU 781213MRole of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer7794292013
 
17117417The molecular regulations, roles, and clinical implications of hypoxia-induced porcupine in hepatocellular carcinoma10147362017
 
HKU 7497/05MRoles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer12719142005
 
HKU 779807MNucleocytoplasmic shuttling mechanism of DLC1 tumor suppressor in liver cancer13881102007
 
03142836Investigation of functional synergism of CENPF and FOXM1 in hepatocellular carcinoma11983762015
 
03142926Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development11999522015
 
17121219Neoadjuvant Immunotherapy with anti-PD1 in Borderline Resectable Hepatocellular Carcinoma10749272019
 
13121212Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway9392802013
 
08192116BRD9 deregulation in liver cancer: Pathological significance and therapeutic potentials15000002020
 
17117019The role of RPS6KA3 mutation in modulating the cholesterol biosynthesis in hepatocellular carcinoma11067192019
 
05163566Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer11980482017
 
07181956Pathological roles of BRPF1 deregulation and its therapeutic implications in liver cancer14997442019
 
07182546Targeting the glycolytic enzyme PFKFB4 in liver cancer underlying p53 mutation: mechanistic insight and therapeutic implication14971502019
 
03142936The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment11999522015
 
InP/230/12Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD471512002012
 
HKU 7392/03MCharacterization of the granulin/epithelin precursor gene in liver cancer10740002003
 
17122214Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression7014702014
 
17142516Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis11310312016
 
03142996Pathological implications and functional characterizations of novel long non-coding RNA linc-CHD1L-1 in hepatocellular carcinoma11176082015
 
HKU 7291/02MFunctional conditioning of dendritic cells for DC-based tumor vaccine8760002002
 
HKU 7674/06MCharacterization of tensin2, the binding partner of DLC1 tumor suppressor in liver cancer9325002006
 
13120932Analysis of hepatitis B virus genomic integration and characterization of its role in hepatocarcinogenesis10000002013
 
HKU 7311/04MRoles and regulation of group II p21-activated protein kinases:-implications in cancer metastasis9399682004
 
HKU 7294/02MFunctional characterization of a novel liver-enriched transcription factor of the bZIP family17860002002
 
10212786Characterization of CASC11, a long noncoding RNA (LncRNA) as a new generation of RNA therapeutics in hepatocellular carcinoma15000002023
 
10212956Multimodal investigations of liquid biopsy in detection and clinical management of hepatocellular carcinoma14988882023
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