The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer


Grant Data
Project Title
The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Principal Investigator
Dr Wong, Carmen Chak Lui   (Principal investigator)
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
1168331
Conference Title
Presentation Title
Keywords
HCC, MDSC, CCL26, HIF, hypoxia
Discipline
Cancer
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17117015
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To examine the regulation of CCL26 in human HCC 3 To elucidate the roles of the HIFs/CCL26 pathway in MDSC recruitment in human HCC 4 To evaluate the effect of pharmacologic inhibition of HIFs and CX3CR1 in MDSC recruitment and HCC progression