The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer

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Grant Data
Project Title
The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Principal Investigator
Dr Wong, Carmen Chak Lui   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
36
Start Date
2015-09-01
Amount
1168331
Conference Title
The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer
Presentation Title
Keywords
CCL26, HCC, HIF, hypoxia, MDSC
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17117015
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To investigate the clinical relevance of MDSC recruitment and CCL26 expression in human HCC 2 To examine the regulation of CCL26 in human HCC 3 To elucidate the roles of the HIFs/CCL26 pathway in MDSC recruitment in human HCC 4 To evaluate the effect of pharmacologic inhibition of HIFs and CX3CR1 in MDSC recruitment and HCC progression