Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development

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Grant Data
Project Title
Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Principal Investigator
Dr Wong, Carmen Chak Lui   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Duration
36
Start Date
2017-01-01
Amount
883035
Conference Title
Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development
Presentation Title
Keywords
folate, hepatocellular carcinoma, MTHFD1L, NADPH, oxidative stress
Discipline
Gastroenterology/Hepatobiliary,Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17153116
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1. To study the clinical significance of MTHFD1L in human HCC 2. To delineate the regulation of MTHFD1L in human HCC 3. To investigate the metabolic roles of the MTHFD1L in human HCC 4. To evaluate the effect of pharmacologic inhibition of the folate cycle in HCC treatment