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Conference Paper: White matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injury
Title | White matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injury |
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Authors | |
Issue Date | 2008 |
Publisher | International Society of Magnetic Resonance in Medicine. |
Citation | The 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, ON., Canada, 3-9 May 2008. In Conference Proceedings, 2008, p. 670 How to Cite? |
Abstract | Purpose: This study aim to investigate the hypoxic-ischemic (HI) injury in brain hemisphere contralateral to ligation in neonatal rats with DTI. Rats with
unilateral left carotid artery ligation were exposed to hypoxic environment for 1 hour (n=9) and 2 hours (n=9) to induce mild and severe HI injuries,
respectively. They, together with intact controls (n=11) were longitudinally examined for changes in FA, axial and radial diffusivities. FA decrease and axial
diffusivity increase were observed during the acute and subacute stage in the hemispheres contralateral to the ligation when compared to controls. The
findings indicated that WM on seemingly normal contralateral hemisphere was indeed adversely affected, which may impact the long-term brain
development after mild or severe HI injury. |
Persistent Identifier | http://hdl.handle.net/10722/99512 |
DC Field | Value | Language |
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dc.contributor.author | Lau, HF | en_HK |
dc.contributor.author | Yang, J | en_HK |
dc.contributor.author | Khong, PL | en_HK |
dc.contributor.author | Wu, EX | en_HK |
dc.date.accessioned | 2010-09-25T18:33:27Z | - |
dc.date.available | 2010-09-25T18:33:27Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | The 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, ON., Canada, 3-9 May 2008. In Conference Proceedings, 2008, p. 670 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/99512 | - |
dc.description.abstract | Purpose: This study aim to investigate the hypoxic-ischemic (HI) injury in brain hemisphere contralateral to ligation in neonatal rats with DTI. Rats with unilateral left carotid artery ligation were exposed to hypoxic environment for 1 hour (n=9) and 2 hours (n=9) to induce mild and severe HI injuries, respectively. They, together with intact controls (n=11) were longitudinally examined for changes in FA, axial and radial diffusivities. FA decrease and axial diffusivity increase were observed during the acute and subacute stage in the hemispheres contralateral to the ligation when compared to controls. The findings indicated that WM on seemingly normal contralateral hemisphere was indeed adversely affected, which may impact the long-term brain development after mild or severe HI injury. | - |
dc.language | eng | en_HK |
dc.publisher | International Society of Magnetic Resonance in Medicine. | - |
dc.relation.ispartof | ISMRM 2008 Annual Scientific Meeting & Exhibition Proceedings | en_HK |
dc.title | White matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injury | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | en_HK |
dc.identifier.authority | Wu, EX=rp00193 | en_HK |
dc.identifier.hkuros | 141570 | en_HK |
dc.identifier.spage | 670 | en_HK |
dc.identifier.epage | 670 | - |