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Article: Association of decreased mitochondrial DNA content with ovarian cancer progression

TitleAssociation of decreased mitochondrial DNA content with ovarian cancer progression
Authors
Wang, YLiu, VWSXue, WCCheung, ANYNgan, HYS
KeywordsCopy number
Mitochondrial DNA
Ovarian carcinoma
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2006, v. 95 n. 8, p. 1087-1091 How to Cite?
DOI: http://dx.doi.org/10.1038/sj.bjc.6603377
AbstractMitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P=0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P=0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas. © 2006 Cancer Research UK.
Persistent Identifierhttp://hdl.handle.net/10722/87223
ISSN
0007-0920
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 3.000
PubMed Central ID
PMC2360719
ISI Accession Number ID
WOS:000241384400022
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:26:55Z-
dc.date.available2010-09-06T09:26:55Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Cancer, 2006, v. 95 n. 8, p. 1087-1091en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87223-
dc.description.abstractMitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P=0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P=0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas. © 2006 Cancer Research UK.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectCopy numberen_HK
dc.subjectMitochondrial DNAen_HK
dc.subjectOvarian carcinomaen_HK
dc.subject.meshAdenocarcinoma, Clear Cell - genetics - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCystadenocarcinoma, Mucinous - genetics - pathologyen_HK
dc.subject.meshCystadenocarcinoma, Serous - genetics - pathologyen_HK
dc.subject.meshDNA Replication - geneticsen_HK
dc.subject.meshDNA, Mitochondrial - genetics - metabolismen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshOvarian Neoplasms - genetics - pathologyen_HK
dc.titleAssociation of decreased mitochondrial DNA content with ovarian cancer progressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=95&spage=1087&epage=1097&date=2006&atitle=Association+of+decreased+mitochondrial+DNA+content+with+ovarian+cancer+progressionen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bjc.6603377en_HK
dc.identifier.pmid17047655en_HK
dc.identifier.pmcidPMC2360719-
dc.identifier.scopuseid_2-s2.0-33750202160en_HK
dc.identifier.hkuros130525en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750202160&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1087en_HK
dc.identifier.epage1091en_HK
dc.identifier.isiWOS:000241384400022-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, Y=49762386700en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.issnl0007-0920-

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