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- Scopus: eid_2-s2.0-0035170725
- PMID: 11712814
- WOS: WOS:000171985000038
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Article: Microsatellite allelotyping of chinese nasopharyngeal carcinomas
Title | Microsatellite allelotyping of chinese nasopharyngeal carcinomas |
---|---|
Authors | |
Keywords | Loss of heterozygosity Microsatellite instability Microsatellite typing Nasopharyngeal carcinoma |
Issue Date | 2001 |
Publisher | International Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/ |
Citation | Anticancer Research, 2001, v. 21 n. 4 B, p. 3081-3084 How to Cite? |
Abstract | Background: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. Materials and Methods: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, 11q and 14q were used to study 47 specimens. Results: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). Conclusion: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significantly associated with earlier staging. |
Persistent Identifier | http://hdl.handle.net/10722/83273 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.562 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lung, ML | en_HK |
dc.contributor.author | Choi, CVM | en_HK |
dc.contributor.author | Kong, H | en_HK |
dc.contributor.author | Yuen, PW | en_HK |
dc.contributor.author | Kwong, D | en_HK |
dc.contributor.author | Sham, J | en_HK |
dc.contributor.author | Wei, WI | en_HK |
dc.date.accessioned | 2010-09-06T08:39:04Z | - |
dc.date.available | 2010-09-06T08:39:04Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Anticancer Research, 2001, v. 21 n. 4 B, p. 3081-3084 | en_HK |
dc.identifier.issn | 0250-7005 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83273 | - |
dc.description.abstract | Background: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. Materials and Methods: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, 11q and 14q were used to study 47 specimens. Results: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). Conclusion: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significantly associated with earlier staging. | en_HK |
dc.language | eng | en_HK |
dc.publisher | International Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/ | en_HK |
dc.relation.ispartof | Anticancer Research | en_HK |
dc.subject | Loss of heterozygosity | en_HK |
dc.subject | Microsatellite instability | en_HK |
dc.subject | Microsatellite typing | en_HK |
dc.subject | Nasopharyngeal carcinoma | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Alleles | en_HK |
dc.subject.mesh | Carcinoma - genetics - mortality | en_HK |
dc.subject.mesh | Chromosomes, Human - genetics | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 11 - genetics | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 14 - genetics | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 3 - genetics | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 6 - genetics | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 9 - genetics | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Hong Kong - epidemiology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Loss of Heterozygosity | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Microsatellite Repeats | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Nasopharyngeal Neoplasms - genetics - mortality | en_HK |
dc.subject.mesh | Prognosis | en_HK |
dc.subject.mesh | Survival Analysis | en_HK |
dc.title | Microsatellite allelotyping of chinese nasopharyngeal carcinomas | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-7005&volume=21&spage=3081&epage=3084&date=2001&atitle=Microsatellite+allelotyping+of+Chinese+nasopharyngeal+carcinomas | en_HK |
dc.identifier.email | Lung, ML: mlilung@hku.hk | en_HK |
dc.identifier.email | Kwong, D: dlwkwong@hku.hk | en_HK |
dc.identifier.email | Wei, WI: hrmswwi@hku.hk | en_HK |
dc.identifier.authority | Lung, ML=rp00300 | en_HK |
dc.identifier.authority | Kwong, D=rp00414 | en_HK |
dc.identifier.authority | Wei, WI=rp00323 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 11712814 | - |
dc.identifier.scopus | eid_2-s2.0-0035170725 | en_HK |
dc.identifier.hkuros | 65969 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035170725&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 21 | en_HK |
dc.identifier.issue | 4 B | en_HK |
dc.identifier.spage | 3081 | en_HK |
dc.identifier.epage | 3084 | en_HK |
dc.identifier.isi | WOS:000171985000038 | - |
dc.publisher.place | Greece | en_HK |
dc.identifier.scopusauthorid | Lung, ML=7006411788 | en_HK |
dc.identifier.scopusauthorid | Choi, CVM=7402961654 | en_HK |
dc.identifier.scopusauthorid | Kong, H=36808058200 | en_HK |
dc.identifier.scopusauthorid | Yuen, PW=7103124007 | en_HK |
dc.identifier.scopusauthorid | Kwong, D=15744231600 | en_HK |
dc.identifier.scopusauthorid | Sham, J=8967933200 | en_HK |
dc.identifier.scopusauthorid | Wei, WI=7403321552 | en_HK |
dc.identifier.issnl | 0250-7005 | - |