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- Publisher Website: 10.1016/S0014-2999(01)01529-1
- Scopus: eid_2-s2.0-0037005736
- PMID: 11755169
- WOS: WOS:000173119400012
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Article: Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats
Title | Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats |
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Authors | |
Keywords | Blood flow Gastric ulcer Glutathione Mucus Nicotine Prostaglandin E2 |
Issue Date | 2002 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 2002, v. 434 n. 1-2, p. 81-86 How to Cite? |
Abstract | Previous studies showed that cigarette smoking was closely associated with gastric ulceration. People usually smoke under stress conditions, and together, these could induce more gastric damage. In the present study, we aimed to study the effects of nicotine administration and its withdrawal on stress-induced gastric ulceration in rats. Male Sprague-Dawley rats were given nicotine (25 or 50 μg/ml) for 10 days and then withdrawn for 2, 4 or 6 days. They were subjected to cold-restraint stress for 2 h after nicotine treatment or after nicotine withdrawal, and then killed. The results indicated that both nicotine treatment and its withdrawal potentiated stress-induced gastric damage. The mucosal glutathione (GSH) and mucus levels were reduced by stress and decreased further by nicotine. The prostaglandin E2 concentration remained unchanged. To conclude, the adverse effect of nicotine on stress ulceration was prostaglandin E2-independent but mediated by the depression of glutathione and mucus levels in the gastric mucosa. © 2002 Elsevier Science B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/80248 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wong, D | en_HK |
dc.contributor.author | Koo, MWL | en_HK |
dc.contributor.author | Shin, VY | en_HK |
dc.contributor.author | Liu, ESL | en_HK |
dc.contributor.author | Cho, CH | en_HK |
dc.date.accessioned | 2010-09-06T08:04:11Z | - |
dc.date.available | 2010-09-06T08:04:11Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | European Journal Of Pharmacology, 2002, v. 434 n. 1-2, p. 81-86 | en_HK |
dc.identifier.issn | 0014-2999 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/80248 | - |
dc.description.abstract | Previous studies showed that cigarette smoking was closely associated with gastric ulceration. People usually smoke under stress conditions, and together, these could induce more gastric damage. In the present study, we aimed to study the effects of nicotine administration and its withdrawal on stress-induced gastric ulceration in rats. Male Sprague-Dawley rats were given nicotine (25 or 50 μg/ml) for 10 days and then withdrawn for 2, 4 or 6 days. They were subjected to cold-restraint stress for 2 h after nicotine treatment or after nicotine withdrawal, and then killed. The results indicated that both nicotine treatment and its withdrawal potentiated stress-induced gastric damage. The mucosal glutathione (GSH) and mucus levels were reduced by stress and decreased further by nicotine. The prostaglandin E2 concentration remained unchanged. To conclude, the adverse effect of nicotine on stress ulceration was prostaglandin E2-independent but mediated by the depression of glutathione and mucus levels in the gastric mucosa. © 2002 Elsevier Science B.V. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_HK |
dc.relation.ispartof | European Journal of Pharmacology | en_HK |
dc.rights | European Journal of Pharmacology. Copyright © Elsevier BV. | en_HK |
dc.subject | Blood flow | en_HK |
dc.subject | Gastric ulcer | en_HK |
dc.subject | Glutathione | en_HK |
dc.subject | Mucus | en_HK |
dc.subject | Nicotine | en_HK |
dc.subject | Prostaglandin E2 | en_HK |
dc.title | Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=434&spage=81&epage=86&date=2002&atitle=Pathogenesis+of+nicotine+treatment+and+its+withdrawal+on+stress-induced+gastric+ulceration+in+rats | en_HK |
dc.identifier.email | Koo, MWL: wlkoo@hku.hk | en_HK |
dc.identifier.authority | Koo, MWL=rp00233 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0014-2999(01)01529-1 | en_HK |
dc.identifier.pmid | 11755169 | - |
dc.identifier.scopus | eid_2-s2.0-0037005736 | en_HK |
dc.identifier.hkuros | 73404 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037005736&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 434 | en_HK |
dc.identifier.issue | 1-2 | en_HK |
dc.identifier.spage | 81 | en_HK |
dc.identifier.epage | 86 | en_HK |
dc.identifier.isi | WOS:000173119400012 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Wong, D=36932587600 | en_HK |
dc.identifier.scopusauthorid | Koo, MWL=7004550899 | en_HK |
dc.identifier.scopusauthorid | Shin, VY=7003491170 | en_HK |
dc.identifier.scopusauthorid | Liu, ESL=7202240071 | en_HK |
dc.identifier.scopusauthorid | Cho, CH=7403100461 | en_HK |
dc.identifier.issnl | 0014-2999 | - |