File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Systemic oxidative and antioxidative status in Chinese patients with asthma

TitleSystemic oxidative and antioxidative status in Chinese patients with asthma
Authors
KeywordsAsthma
BAL
Bronchoalveolar lavage
catalase
erythrocyte
Glutathione disulfide, or oxidized GSH
Glutathione peroxidase
glutathione peroxidase
GPx
GSH
GSSG
Hb
Hemoglobin
oxidative stress
oxidized glutathione
Reduced glutathione
superoxide dismutase
Issue Date2004
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jaci
Citation
Journal Of Allergy And Clinical Immunology, 2004, v. 114 n. 2, p. 260-264 How to Cite?
AbstractBackground Patients with asthma generate an increased amount of reactive oxygen species from peripheral blood cells. Reactive oxygen species produce many of the pathophysiologic changes associated with asthma and may contribute to its pathogenesis. Objective We investigated changes in antioxidant enzyme activities and oxidized glutathione (glutathione disulfide; GSSG) levels in erythrocytes from a group of healthy control Chinese subjects (n=135) and patients with asthma (n=106). Methods Baseline pulmonary function was measured for all subjects. Antioxidant status was evaluated by measuring erythrocyte superoxide dismutase, catalase, and glutathione peroxidase activities. Oxidative stress was also measured in terms of GSSG in erythrocytes with a kinetic microassay. Results Patients with asthma had significantly increased erythrocyte superoxide dismutase and catalase activities compared with controls (61.10 ± 1.30 U/g hemoglobin [Hb] vs 55.51 ± 1.82 U/g Hb [P=.018] and 0.0637 ± 0.0021 U/g Hb vs 0.0257 ± 0.0120 U/g Hb [P < .001] for the asthma and control groups, respectively). Conversely, erythrocyte glutathione peroxidase activity decreased (44.21 ± 1.33 mU/g Hb vs 50.07 ± 1.39 mU/g Hb for the asthma and control groups, respectively; P=.003). Patients with asthma also had significantly higher GSSG levels in erythrocyte hemolysates compared with controls (167.40 ± 2.93 μmol/L vs 44.98 ± 0.44 μmol/L for the asthma and control groups, respectively; P < .001), indicating increased oxidative stress. Conclusions Asthma is accompanied by an alteration in systemic antioxidant status due to possible oxidative stress in this disease.
Persistent Identifierhttp://hdl.handle.net/10722/77483
ISSN
2023 Impact Factor: 11.4
2023 SCImago Journal Rankings: 3.701
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorLeung, HCMen_HK
dc.contributor.authorHo, SPen_HK
dc.contributor.authorLaw, BKWen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorChanYeung, Men_HK
dc.date.accessioned2010-09-06T07:32:23Z-
dc.date.available2010-09-06T07:32:23Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Allergy And Clinical Immunology, 2004, v. 114 n. 2, p. 260-264en_HK
dc.identifier.issn0091-6749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77483-
dc.description.abstractBackground Patients with asthma generate an increased amount of reactive oxygen species from peripheral blood cells. Reactive oxygen species produce many of the pathophysiologic changes associated with asthma and may contribute to its pathogenesis. Objective We investigated changes in antioxidant enzyme activities and oxidized glutathione (glutathione disulfide; GSSG) levels in erythrocytes from a group of healthy control Chinese subjects (n=135) and patients with asthma (n=106). Methods Baseline pulmonary function was measured for all subjects. Antioxidant status was evaluated by measuring erythrocyte superoxide dismutase, catalase, and glutathione peroxidase activities. Oxidative stress was also measured in terms of GSSG in erythrocytes with a kinetic microassay. Results Patients with asthma had significantly increased erythrocyte superoxide dismutase and catalase activities compared with controls (61.10 ± 1.30 U/g hemoglobin [Hb] vs 55.51 ± 1.82 U/g Hb [P=.018] and 0.0637 ± 0.0021 U/g Hb vs 0.0257 ± 0.0120 U/g Hb [P < .001] for the asthma and control groups, respectively). Conversely, erythrocyte glutathione peroxidase activity decreased (44.21 ± 1.33 mU/g Hb vs 50.07 ± 1.39 mU/g Hb for the asthma and control groups, respectively; P=.003). Patients with asthma also had significantly higher GSSG levels in erythrocyte hemolysates compared with controls (167.40 ± 2.93 μmol/L vs 44.98 ± 0.44 μmol/L for the asthma and control groups, respectively; P < .001), indicating increased oxidative stress. Conclusions Asthma is accompanied by an alteration in systemic antioxidant status due to possible oxidative stress in this disease.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacien_HK
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_HK
dc.rightsJournal of Allergy and Clinical Immunology. Copyright © Mosby, Inc.en_HK
dc.subjectAsthma-
dc.subjectBAL-
dc.subjectBronchoalveolar lavage-
dc.subjectcatalase-
dc.subjecterythrocyte-
dc.subjectGlutathione disulfide, or oxidized GSH-
dc.subjectGlutathione peroxidase-
dc.subjectglutathione peroxidase-
dc.subjectGPx-
dc.subjectGSH-
dc.subjectGSSG-
dc.subjectHb-
dc.subjectHemoglobin-
dc.subjectoxidative stress-
dc.subjectoxidized glutathione-
dc.subjectReduced glutathione-
dc.subjectsuperoxide dismutase-
dc.subject.meshAdulten_HK
dc.subject.meshAsthma - metabolismen_HK
dc.subject.meshCatalase - blooden_HK
dc.subject.meshErythrocytes - enzymologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlutathione Disulfide - blooden_HK
dc.subject.meshGlutathione Peroxidase - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshSuperoxide Dismutase - blooden_HK
dc.titleSystemic oxidative and antioxidative status in Chinese patients with asthmaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0091-6749&volume=114&issue=2&spage=260&epage=264&date=2004&atitle=Systemic+oxidative+and+antioxidative+status+in+Chinese+patients+with+asthmaen_HK
dc.identifier.emailMak, JCW:judymak@hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jaci.2004.05.013en_HK
dc.identifier.pmid15316500-
dc.identifier.scopuseid_2-s2.0-4344613618en_HK
dc.identifier.hkuros97421en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344613618&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue2en_HK
dc.identifier.spage260en_HK
dc.identifier.epage264en_HK
dc.identifier.isiWOS:000223405600007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMak, JCW=7103323094en_HK
dc.identifier.scopusauthoridLeung, HCM=34968372500en_HK
dc.identifier.scopusauthoridHo, SP=12794365900en_HK
dc.identifier.scopusauthoridLaw, BKW=36639650600en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.issnl0091-6749-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats