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Conference Paper: Are intelligence and memory good endophenotypes for schizophrenia? Genetic models in a harvard, IOP, and NIH collaboration
Title | Are intelligence and memory good endophenotypes for schizophrenia? Genetic models in a harvard, IOP, and NIH collaboration |
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Authors | |
Issue Date | 2009 |
Citation | The 12th International Congress on Schizophrenia Research, San Diego, CA., 28 March-1 April 2009. In Schizophrenia Bulletin, 2009, v. 35 suppl 1, p. 110-110 How to Cite? |
Abstract | Context: Impairments in verbal and visual memory, verbal learning and
intelligence are among the most promising indicators of increased risk
for schizophrenia making them candidate endophenotypes; however it is
not clear to what extent these deficits are genetically linked to the disorder.
Objective: To quantify the net genetic relationship between episodic memory,
learning, intelligence and schizophrenia in a large multi-site data. Design:
Family and twin study. Setting: US and UK Research Institutes.
Participants: Data from 2057 individuals were pooled across three sites:
1) Harvard University,USA (2) Institute of Psychiatry,UK and (3) National
Institute of Health,USA. Of these individuals 657 were patients,
674 1st degree relatives and 726 were controls. Main outcome measures:
The heritabilities of memory, learning and intelligence were estimated
and the genetic relationship between each one of these and schizophrenia
quantified. Results: Genetic influences contributed to all cognitive
domains with intelligence showing the highest heritability (h2 = 0.69)
and immediate recall of verbal memory the least (h2 = 0.30). Significant
genetic correlations were found between schizophrenia and 1) immediate
(I)/delayed (D) verbal recall (I: 0.96; D: 0.94); 2) I/D verbal learning (I:
0.47; D: 0.30) and 3) I/D visual recall (I: 0.62; D: 0.68) suggesting
that schizophrenia and these measures share to some extent the same genes.
When the heritabilities of these measures were taken into account, intelligence
showed the biggest phenotypic correlation with schizophrenia
( .49) with shared genetic influences explaining chiefly the phenotypic
co-variance. Conclusion: Unlike molecular genetic approaches which estimate
the extent to which allelic variation explains endophenotypic variance,
genetic modeling quantifies the net shared genetic influences
between the candidate endophenotype and the illness, giving a broader
view of the degree of genetic overlap between the two. Supporting our previous
work in twins (Toulopoulou et al. 2007) intelligence appears to be the
best endophenotype for schizophrenia sharing the greatest genetic variance
with the illness. Genome wide searches using a bivariate phenotype such as
schizophrenia and intelligence should assist in the search to find quantitative
trait loci for schizophrenia. |
Persistent Identifier | http://hdl.handle.net/10722/62700 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 2.249 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Toulopoulou, T | en_HK |
dc.contributor.author | Goldberg, T | en_HK |
dc.contributor.author | Weinberger, DR | en_HK |
dc.contributor.author | Rijsdijk, F | en_HK |
dc.contributor.author | Faraone, S | en_HK |
dc.contributor.author | Tsuang, M | en_HK |
dc.contributor.author | Stahl, D | en_HK |
dc.contributor.author | Picchioni, M | en_HK |
dc.contributor.author | Sham, PC | en_HK |
dc.contributor.author | Cherny, SS | en_HK |
dc.contributor.author | Murray, R | en_HK |
dc.contributor.author | Seidman, L | en_HK |
dc.date.accessioned | 2010-07-13T04:07:11Z | - |
dc.date.available | 2010-07-13T04:07:11Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | The 12th International Congress on Schizophrenia Research, San Diego, CA., 28 March-1 April 2009. In Schizophrenia Bulletin, 2009, v. 35 suppl 1, p. 110-110 | en_HK |
dc.identifier.issn | 0586-7614 | - |
dc.identifier.uri | http://hdl.handle.net/10722/62700 | - |
dc.description.abstract | Context: Impairments in verbal and visual memory, verbal learning and intelligence are among the most promising indicators of increased risk for schizophrenia making them candidate endophenotypes; however it is not clear to what extent these deficits are genetically linked to the disorder. Objective: To quantify the net genetic relationship between episodic memory, learning, intelligence and schizophrenia in a large multi-site data. Design: Family and twin study. Setting: US and UK Research Institutes. Participants: Data from 2057 individuals were pooled across three sites: 1) Harvard University,USA (2) Institute of Psychiatry,UK and (3) National Institute of Health,USA. Of these individuals 657 were patients, 674 1st degree relatives and 726 were controls. Main outcome measures: The heritabilities of memory, learning and intelligence were estimated and the genetic relationship between each one of these and schizophrenia quantified. Results: Genetic influences contributed to all cognitive domains with intelligence showing the highest heritability (h2 = 0.69) and immediate recall of verbal memory the least (h2 = 0.30). Significant genetic correlations were found between schizophrenia and 1) immediate (I)/delayed (D) verbal recall (I: 0.96; D: 0.94); 2) I/D verbal learning (I: 0.47; D: 0.30) and 3) I/D visual recall (I: 0.62; D: 0.68) suggesting that schizophrenia and these measures share to some extent the same genes. When the heritabilities of these measures were taken into account, intelligence showed the biggest phenotypic correlation with schizophrenia ( .49) with shared genetic influences explaining chiefly the phenotypic co-variance. Conclusion: Unlike molecular genetic approaches which estimate the extent to which allelic variation explains endophenotypic variance, genetic modeling quantifies the net shared genetic influences between the candidate endophenotype and the illness, giving a broader view of the degree of genetic overlap between the two. Supporting our previous work in twins (Toulopoulou et al. 2007) intelligence appears to be the best endophenotype for schizophrenia sharing the greatest genetic variance with the illness. Genome wide searches using a bivariate phenotype such as schizophrenia and intelligence should assist in the search to find quantitative trait loci for schizophrenia. | - |
dc.language | eng | en_HK |
dc.relation.ispartof | Schizophrenia Bulletin | - |
dc.title | Are intelligence and memory good endophenotypes for schizophrenia? Genetic models in a harvard, IOP, and NIH collaboration | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Sham, PC: pcsham@HKUCC.hku.hk | en_HK |
dc.identifier.email | Cherny, SS: cherny@hku.hk | en_HK |
dc.identifier.authority | Sham, PC=rp00459 | en_HK |
dc.identifier.authority | Cherny, SS=rp00232 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/schbul/sbn173 | - |
dc.identifier.pmid | 19252181 | - |
dc.identifier.pmcid | PMC2651108 | - |
dc.identifier.scopus | eid_2-s2.0-67549145653 | - |
dc.identifier.hkuros | 158189 | en_HK |
dc.identifier.isi | WOS:000263964700003 | - |
dc.identifier.issnl | 0586-7614 | - |