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Conference Paper: Association of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma
Title | Association of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma |
---|---|
Authors | |
Issue Date | 2009 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep |
Citation | The 44th Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2009), Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 suppl. 1, p. S146-S147 How to Cite? |
Abstract | Background and Aims: Recent studies suggest that hepatitis B virus
(HBV) pre-S/S mutations are associated with hepatocellular carcinoma
(HCC) development [1, 2]. However, in these case-control studies, patients
were not matched for age, gender and hepatitis B e-antigen (HBeAg)
status. We aimed to investigate the association between pre-S deletions
and HCC using
1) a matched case-control approach and
2) a longitudinal approach. In addition, the association between pre-S
deletions and HBeAg seroconversion was investigated.
Methods: HBV pre-S deletions were determined by DNA sequencing
in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B
(CHB) patients matched with age, gender and HBeAg status, as well as in
sera collected before the development of HCC. HBV pre-S deletions were
also determined in 76 non-HCC CHB patients before and after HBeAg
seroconversion.
Results: Pre-S deletions were detected in 33 out of 117 HCC cases
(28.2%). At the time of writing, nucleotide sequence analysis in 78
HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC
(19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal
study, serum samples collected 1−7 years before HCC development
were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were
absent in 4 cases before HCC development (25.0%).
Pre-S deletions were also assessed in serum samples collected from 76
non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before
HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after
seroconversion. Seven patients had newly emerged pre-S deletions after
HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg
seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated
with HCC development. 25% of HCC patients had developed
pre-S deletions within 1 year before the occurrence of HCC. However its
association with HBeAg seroconversion was not clear. These results are
being validated by our on-going studies with a larger number of patients.
References
[1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8.
[2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098–
103. |
Persistent Identifier | http://hdl.handle.net/10722/62370 |
ISSN | 2023 Impact Factor: 26.8 2023 SCImago Journal Rankings: 9.857 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yeung, P | - |
dc.contributor.author | Wong, DKH | - |
dc.contributor.author | Fung, JYY | - |
dc.contributor.author | Yuen, JCH | - |
dc.contributor.author | Fung, FKC | - |
dc.contributor.author | Lai, CL | - |
dc.contributor.author | Yuen, RMF | - |
dc.date.accessioned | 2010-07-13T03:59:48Z | - |
dc.date.available | 2010-07-13T03:59:48Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | The 44th Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2009), Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 suppl. 1, p. S146-S147 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/10722/62370 | - |
dc.description.abstract | Background and Aims: Recent studies suggest that hepatitis B virus (HBV) pre-S/S mutations are associated with hepatocellular carcinoma (HCC) development [1, 2]. However, in these case-control studies, patients were not matched for age, gender and hepatitis B e-antigen (HBeAg) status. We aimed to investigate the association between pre-S deletions and HCC using 1) a matched case-control approach and 2) a longitudinal approach. In addition, the association between pre-S deletions and HBeAg seroconversion was investigated. Methods: HBV pre-S deletions were determined by DNA sequencing in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B (CHB) patients matched with age, gender and HBeAg status, as well as in sera collected before the development of HCC. HBV pre-S deletions were also determined in 76 non-HCC CHB patients before and after HBeAg seroconversion. Results: Pre-S deletions were detected in 33 out of 117 HCC cases (28.2%). At the time of writing, nucleotide sequence analysis in 78 HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC (19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal study, serum samples collected 1−7 years before HCC development were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were absent in 4 cases before HCC development (25.0%). Pre-S deletions were also assessed in serum samples collected from 76 non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after seroconversion. Seven patients had newly emerged pre-S deletions after HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated with HCC development. 25% of HCC patients had developed pre-S deletions within 1 year before the occurrence of HCC. However its association with HBeAg seroconversion was not clear. These results are being validated by our on-going studies with a larger number of patients. References [1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8. [2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098– 103. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep | - |
dc.relation.ispartof | Journal of Hepatology | - |
dc.rights | © 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.title | Association of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma | - |
dc.type | Conference_Paper | - |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=50&issue=Suppl 1&spage=S146&epage=S147&date=2009&atitle=Association+of+hepatitis+B+virus+pre-S+deletions+with+the+risk+of+development+of+hepatocellular+carcinoma | en_HK |
dc.identifier.email | Yeung, P: yeungpok@hkusua.hku.hk | - |
dc.identifier.email | Wong, DKH: danywong@hku.hk | - |
dc.identifier.email | Fung, JYY: jfung@HKUCC.hku.hk | - |
dc.identifier.email | Yuen, JCH: jchyuen@HKUCC.hku.hk | - |
dc.identifier.email | Fung, FKC: frederic@HKUCC.hku.hk | - |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | - |
dc.identifier.email | Yuen, RMF: mfyuen@hkucc.hku.hk | - |
dc.identifier.authority | Wong, DKH=rp00492 | - |
dc.identifier.authority | Fung, JYY=rp00518 | - |
dc.identifier.authority | Lai, CL=rp00314 | - |
dc.identifier.authority | Yuen, RMF=rp00479 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0168-8278(09)60388-3 | - |
dc.identifier.hkuros | 161376 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | suppl. 1 | - |
dc.identifier.spage | S146 | - |
dc.identifier.epage | S147 | - |
dc.identifier.isi | WOS:000266384700387 | - |
dc.publisher.place | The Netherlands | - |
dc.identifier.issnl | 0168-8278 | - |