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Conference Paper: Characterization of cortex and white matter injury in a mild hypoxic-ischemic neonatal rat mode by diffusion tensor MR imaging
| Title | Characterization of cortex and white matter injury in a mild hypoxic-ischemic neonatal rat mode by diffusion tensor MR imaging |
|---|---|
| Authors | |
| Issue Date | 2009 |
| Publisher | International Society of Magnetic Resonance in Medicine. |
| Citation | The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3594 How to Cite? |
| Abstract | We evaluated hypoxic-ischemic (HI) induced cortex and white matter (WM) damage in a mild HI neonatal rat model at 24h post HI by diffusion tensor MR imaging (DTI) and correlated the DTI indices with histological evaluations. Results showed that significantly decreased FA and ¦Ë// reflected HI induced astrogliosis in the injured cortex, whereas significantly decreased FA with increased ¦Ë¡Í indicated dysmyelination in the WM. Our results demonstrated that early mild HI induced cortex and WM damage could be reflected by DTI indices and these may be potentially useful biomarkers to non-invasively monitor mild HI induced neonatal brain damage. |
| Description | Animal Studies: Diffusion & Perfusion - Poster presentation |
| Persistent Identifier | http://hdl.handle.net/10722/62092 |
| ISBN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wang, S | en_HK |
| dc.contributor.author | Wu, EX | en_HK |
| dc.contributor.author | Lau, HF | en_HK |
| dc.contributor.author | Khong, PK | en_HK |
| dc.date.accessioned | 2010-07-13T03:53:43Z | - |
| dc.date.available | 2010-07-13T03:53:43Z | - |
| dc.date.issued | 2009 | en_HK |
| dc.identifier.citation | The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3594 | en_HK |
| dc.identifier.isbn | 9781615673384 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/62092 | - |
| dc.description | Animal Studies: Diffusion & Perfusion - Poster presentation | - |
| dc.description.abstract | We evaluated hypoxic-ischemic (HI) induced cortex and white matter (WM) damage in a mild HI neonatal rat model at 24h post HI by diffusion tensor MR imaging (DTI) and correlated the DTI indices with histological evaluations. Results showed that significantly decreased FA and ¦Ë// reflected HI induced astrogliosis in the injured cortex, whereas significantly decreased FA with increased ¦Ë¡Í indicated dysmyelination in the WM. Our results demonstrated that early mild HI induced cortex and WM damage could be reflected by DTI indices and these may be potentially useful biomarkers to non-invasively monitor mild HI induced neonatal brain damage. | - |
| dc.language | eng | en_HK |
| dc.publisher | International Society of Magnetic Resonance in Medicine. | - |
| dc.relation.ispartof | Proceedings of ISMRM 17th Scientific Meeting & Exhibition | - |
| dc.title | Characterization of cortex and white matter injury in a mild hypoxic-ischemic neonatal rat mode by diffusion tensor MR imaging | en_HK |
| dc.type | Conference_Paper | en_HK |
| dc.identifier.email | Wang, S: pkuwangsilun@yahoo.com.cn | en_HK |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
| dc.identifier.email | Lau, HF: lauhofai@gmail.com | - |
| dc.identifier.email | Khong, PK: plkhong@hkucc.hku.hk | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.hkuros | 162091 | en_HK |
| dc.identifier.spage | 3594 | - |
| dc.identifier.epage | 3594 | - |
| dc.publisher.place | United States | - |
| dc.description.other | The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3594 | - |