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Article: The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

TitleThe development and genetic diversity of H5N1 influenza virus in China, 1996-2006
Authors
Duan, LBahl, JSmith, GJDWang, JVijaykrishna, DZhang, LJZhang, JXLi, KSFan, XHCheung, CLHuang, KPoon, LLMShortridge, KFWebster, RGPeiris, JSMChen, HGuan, Y
KeywordsAvian influenza
Genotype
Reassortant
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2008, v. 380 n. 2, p. 243-254 How to Cite?
DOI: http://dx.doi.org/10.1016/j.virol.2008.07.038
AbstractSince it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005. © 2008 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59383
ISSN
0042-6822
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.838
PubMed Central ID
PMC2651962
ISI Accession Number ID
WOS:000260148400010
Funding AgencyGrant Number
Li Ka Shing Foundation
National Institutes of HealthHHSN266200700005C
Hong Kong SAR GovernmentAoE/M-12/06
Funding Information:

This study was supported by the Li Ka Shing Foundation, the National Institutes of Health (NIAID contract HHSN266200700005C), and the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) of the Hong Kong SAR Government.

References
References in Scopus
Grants
Control of Pandemic and Inter-pandemic Influenza

 

DC FieldValueLanguage
dc.contributor.authorDuan, Len_HK
dc.contributor.authorBahl, Jen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-05-31T03:48:59Z-
dc.date.available2010-05-31T03:48:59Z-
dc.date.issued2008en_HK
dc.identifier.citationVirology, 2008, v. 380 n. 2, p. 243-254en_HK
dc.identifier.issn0042-6822en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59383-
dc.description.abstractSince it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005. © 2008 Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_HK
dc.relation.ispartofVirologyen_HK
dc.subjectAvian influenzaen_HK
dc.subjectGenotypeen_HK
dc.subjectReassortanten_HK
dc.subject.meshChinaen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshGenetic Variationen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - classification - genetics - isolation & purificationen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshRNA, Viral - geneticsen_HK
dc.subject.meshReassortant Viruses - classification - genetics - isolation & purificationen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.subject.meshSequence Homologyen_HK
dc.titleThe development and genetic diversity of H5N1 influenza virus in China, 1996-2006en_HK
dc.typeArticleen_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.virol.2008.07.038en_HK
dc.identifier.pmid18774155-
dc.identifier.pmcidPMC2651962-
dc.identifier.scopuseid_2-s2.0-53249130653en_HK
dc.identifier.hkuros157665en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53249130653&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume380en_HK
dc.identifier.issue2en_HK
dc.identifier.spage243en_HK
dc.identifier.epage254en_HK
dc.identifier.isiWOS:000260148400010-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridDuan, L=7201932765en_HK
dc.identifier.scopusauthoridBahl, J=35308668200en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridZhang, LJ=22137301100en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.citeulike4340439-
dc.identifier.issnl0042-6822-

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