File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China

TitleMolecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China
Authors
Issue Date2004
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2004, v. 78 n. 24, p. 13591-13599 How to Cite?
AbstractChina is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collected from PBD, IDU, and their sexual partners in the most severely affected provinces, such as Henan, Yunnan, Guangxi, and Xinjiang. PCR was used to amplify the p17 region of gag and the C2-V3 region of env of HIV-1 and the 5′ noncoding region and a region of E1/E2 of HCV. Genetic characterization of viral sequences indicated that there are two major epidemics of HIV-1 and multiple HCV epidemics in China. The PBD and transfusion recipients in Henan harbored HIV-1 subtype B', which is similar to the virus found in Thailand, and HCV genotypes 1b and 2a, whereas the IDU in Yunnan, Guangxi, and Xinjiang carried HIV-1 circulating recombinant forms 07 and 08, which resemble those in India, and HCV genotypes 1b, 3a, and 3b. Our findings show that the epidemics of HIV-1 and HCV infection in China are the consequences of multiple introductions. The distinct distribution patterns of both the HIV-1 and HCV genotypes in the different high-risk groups are tightly linked to the mode of transmission rather than geographic proximity. These findings provide information relevant to antiviral therapy and vaccine development in China and should assist public health workers in implementing measures to reduce the further dissemination of these viruses in the world's most populous nation.
Persistent Identifierhttp://hdl.handle.net/10722/49135
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Len_HK
dc.contributor.authorChen, Zen_HK
dc.contributor.authorCao, Yen_HK
dc.contributor.authorYu, Jen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorYu, Wen_HK
dc.contributor.authorYin, Nen_HK
dc.contributor.authorMei, Sen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorBalfe, Pen_HK
dc.contributor.authorHe, Ten_HK
dc.contributor.authorBa, Len_HK
dc.contributor.authorZhang, Fen_HK
dc.contributor.authorLin, HHen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorHo, DDen_HK
dc.date.accessioned2008-06-12T06:35:10Z-
dc.date.available2008-06-12T06:35:10Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal of Virology, 2004, v. 78 n. 24, p. 13591-13599en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49135-
dc.description.abstractChina is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collected from PBD, IDU, and their sexual partners in the most severely affected provinces, such as Henan, Yunnan, Guangxi, and Xinjiang. PCR was used to amplify the p17 region of gag and the C2-V3 region of env of HIV-1 and the 5′ noncoding region and a region of E1/E2 of HCV. Genetic characterization of viral sequences indicated that there are two major epidemics of HIV-1 and multiple HCV epidemics in China. The PBD and transfusion recipients in Henan harbored HIV-1 subtype B', which is similar to the virus found in Thailand, and HCV genotypes 1b and 2a, whereas the IDU in Yunnan, Guangxi, and Xinjiang carried HIV-1 circulating recombinant forms 07 and 08, which resemble those in India, and HCV genotypes 1b, 3a, and 3b. Our findings show that the epidemics of HIV-1 and HCV infection in China are the consequences of multiple introductions. The distinct distribution patterns of both the HIV-1 and HCV genotypes in the different high-risk groups are tightly linked to the mode of transmission rather than geographic proximity. These findings provide information relevant to antiviral therapy and vaccine development in China and should assist public health workers in implementing measures to reduce the further dissemination of these viruses in the world's most populous nation.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.subject.meshBlood Donorsen_HK
dc.subject.meshHIV Infections - epidemiology - virologyen_HK
dc.subject.meshHIV-1 - classification - geneticsen_HK
dc.subject.meshHepacivirus - classification - geneticsen_HK
dc.subject.meshHepatitis C - epidemiology - virologyen_HK
dc.titleMolecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityChen, Z=rp00243en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1128/JVI.78.24.13591-13599.2004en_HK
dc.identifier.pmid15564470-
dc.identifier.pmcidPMC533913en_HK
dc.identifier.scopuseid_2-s2.0-10044230829en_HK
dc.identifier.hkuros97681-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10044230829&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue24en_HK
dc.identifier.spage13591en_HK
dc.identifier.epage13599en_HK
dc.identifier.isiWOS:000225409900021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, L=8783285300en_HK
dc.identifier.scopusauthoridChen, Z=35271180800en_HK
dc.identifier.scopusauthoridCao, Y=7404524310en_HK
dc.identifier.scopusauthoridYu, J=7405525088en_HK
dc.identifier.scopusauthoridLi, G=36123500200en_HK
dc.identifier.scopusauthoridYu, W=7403914045en_HK
dc.identifier.scopusauthoridYin, N=36124460800en_HK
dc.identifier.scopusauthoridMei, S=7102846403en_HK
dc.identifier.scopusauthoridLi, L=36064664900en_HK
dc.identifier.scopusauthoridBalfe, P=24323855700en_HK
dc.identifier.scopusauthoridHe, T=16935084000en_HK
dc.identifier.scopusauthoridBa, L=8557032300en_HK
dc.identifier.scopusauthoridZhang, F=10640508100en_HK
dc.identifier.scopusauthoridLin, HH=36123401000en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridHo, DD=7402971998en_HK
dc.identifier.issnl0022-538X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats