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Article: Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
Title | Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice |
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Authors | |
Keywords | Angelica sinensis Polysaccharides Cyclophosphamide Leukopenia Gastrointestinal tract |
Issue Date | 2006 |
Publisher | Ivyspring International Publisher. The Journal's web site is located at http://www.medsci.org/ |
Citation | International Journal of Medical Sciences, 2006, v. 3 n. 1, p. 1-6 How to Cite? |
Abstract | Cyclophosphamide (CY) is a cytostatic agent that produces systemic toxicity especially on cells with high proliferative capacity, while polysaccharides from Angelica sinensis (AP) have been shown to increase the turnover of gastrointestinal mucosal and hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on CY-induced leukopenia and proliferative arrest in the gastroduodenal mucosa in mice. Subcutaneous injection of CY (200 mg/kg) provoked dramatic decrease in white blood cell (WBC) count and number of blood vessels and proliferating cells in both the gastric and duodenal mucosae. Subcutaneous injection of AP significantly promoted the recovery from leukopenia and increased number of blood vessels and proliferating cells in both the gastric and duodenal tissues. Western blotting revealed that CY significantly down-regulated the protein expression of vascular endothelial growth factor (VEGF), c-Myc and ornithine decarboxylase (ODC) in gastric mucosae but had no effect on epidermal growth factor (EGF) expression. AP also reversed the dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hematopoietic and gastrointestinal tissues when the polysaccharide is co-administered with CY in cancer patients during treatment regimen. |
Persistent Identifier | http://hdl.handle.net/10722/45239 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID |
DC Field | Value | Language |
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dc.contributor.author | Hui, MKC | en_HK |
dc.contributor.author | Wu, WKK | en_HK |
dc.contributor.author | Shin, VY | en_HK |
dc.contributor.author | So, WHL | en_HK |
dc.contributor.author | Cho, CH | en_HK |
dc.date.accessioned | 2007-10-30T06:20:38Z | - |
dc.date.available | 2007-10-30T06:20:38Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | International Journal of Medical Sciences, 2006, v. 3 n. 1, p. 1-6 | en_HK |
dc.identifier.issn | 1449-1907 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/45239 | - |
dc.description.abstract | Cyclophosphamide (CY) is a cytostatic agent that produces systemic toxicity especially on cells with high proliferative capacity, while polysaccharides from Angelica sinensis (AP) have been shown to increase the turnover of gastrointestinal mucosal and hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on CY-induced leukopenia and proliferative arrest in the gastroduodenal mucosa in mice. Subcutaneous injection of CY (200 mg/kg) provoked dramatic decrease in white blood cell (WBC) count and number of blood vessels and proliferating cells in both the gastric and duodenal mucosae. Subcutaneous injection of AP significantly promoted the recovery from leukopenia and increased number of blood vessels and proliferating cells in both the gastric and duodenal tissues. Western blotting revealed that CY significantly down-regulated the protein expression of vascular endothelial growth factor (VEGF), c-Myc and ornithine decarboxylase (ODC) in gastric mucosae but had no effect on epidermal growth factor (EGF) expression. AP also reversed the dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hematopoietic and gastrointestinal tissues when the polysaccharide is co-administered with CY in cancer patients during treatment regimen. | en_HK |
dc.format.extent | 422269 bytes | - |
dc.format.extent | 2097 bytes | - |
dc.format.extent | 3803 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Ivyspring International Publisher. The Journal's web site is located at http://www.medsci.org/ | en_HK |
dc.relation.ispartof | International Journal of Medical Sciences | - |
dc.subject | Angelica sinensis | en_HK |
dc.subject | Polysaccharides | en_HK |
dc.subject | Cyclophosphamide | en_HK |
dc.subject | Leukopenia | en_HK |
dc.subject | Gastrointestinal tract | en_HK |
dc.title | Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1449-1907&volume=3&issue=1&spage=1&epage=6&date=2006&atitle=Polysaccharides+from+the+root+of+Angelica+sinensis+protect+bone+marrow+and+gastrointestinal+tissues+against+the+cytotoxicity+of+cyclophosphamide+in+mice | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.pmid | 16421623 | en_HK |
dc.identifier.pmcid | PMC1332197 | - |
dc.identifier.scopus | eid_2-s2.0-29944443508 | - |
dc.identifier.hkuros | 119605 | - |
dc.identifier.issnl | 1449-1907 | - |