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Article: Prognostic factors in severe exacerbation of chronic hepatitis B
Title | Prognostic factors in severe exacerbation of chronic hepatitis B |
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Authors | |
Issue Date | 2003 |
Publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/ |
Citation | Clinical Infectious Diseases, 2003, v. 36 n. 8, p. 979-984 How to Cite? |
Abstract | Forty-seven patients with severe hepatitis B exacerbation were compared with patients who had mild exacerbation (n = 96) or no exacerbation (n = 96). Seventeen patients (36.2%) died or underwent liver transplantation. Preexisting cirrhosis and a prothrombin time (PT) of >30 s were associated with adverse outcome in 60.9% and 87.5% of patients, respectively. The rate of adverse outcome increased to 92.3% when albumin levels of ≤35 g/L and bilirubin levels of >200 μM were present. Other factors associated with adverse outcomes included peak bilirubin level, peak PT, time to reach peak PT, and the presence of encephalopathy and/or ascites. There was no difference in the frequency of precore mutations in patients with severe or mild exacerbation or without exacerbation. A significantly lower prevalence of core promoter mutants was found in patients with severe exacerbation (50%), compared with those who had mild exacerbation (81.3%; P = .004). Patients with severe exacerbation of hepatitis B with poor prognostic factors should be considered for early liver transplantation. |
Persistent Identifier | http://hdl.handle.net/10722/42151 |
ISSN | 2023 Impact Factor: 8.2 2023 SCImago Journal Rankings: 3.308 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuen, MF | en_HK |
dc.contributor.author | Sablon, E | en_HK |
dc.contributor.author | Hui, CK | en_HK |
dc.contributor.author | Li, TM | en_HK |
dc.contributor.author | Yuan, HJ | en_HK |
dc.contributor.author | Wong, DKH | en_HK |
dc.contributor.author | Doutreloigne, J | en_HK |
dc.contributor.author | Bogaerts, V | en_HK |
dc.contributor.author | Wong, BCY | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.date.accessioned | 2007-01-08T02:30:20Z | - |
dc.date.available | 2007-01-08T02:30:20Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Clinical Infectious Diseases, 2003, v. 36 n. 8, p. 979-984 | en_HK |
dc.identifier.issn | 1058-4838 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/42151 | - |
dc.description.abstract | Forty-seven patients with severe hepatitis B exacerbation were compared with patients who had mild exacerbation (n = 96) or no exacerbation (n = 96). Seventeen patients (36.2%) died or underwent liver transplantation. Preexisting cirrhosis and a prothrombin time (PT) of >30 s were associated with adverse outcome in 60.9% and 87.5% of patients, respectively. The rate of adverse outcome increased to 92.3% when albumin levels of ≤35 g/L and bilirubin levels of >200 μM were present. Other factors associated with adverse outcomes included peak bilirubin level, peak PT, time to reach peak PT, and the presence of encephalopathy and/or ascites. There was no difference in the frequency of precore mutations in patients with severe or mild exacerbation or without exacerbation. A significantly lower prevalence of core promoter mutants was found in patients with severe exacerbation (50%), compared with those who had mild exacerbation (81.3%; P = .004). Patients with severe exacerbation of hepatitis B with poor prognostic factors should be considered for early liver transplantation. | en_HK |
dc.format.extent | 102246 bytes | - |
dc.format.extent | 3035 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/ | en_HK |
dc.relation.ispartof | Clinical Infectious Diseases | en_HK |
dc.rights | Clinical Infectious Diseases. Copyright © University of Chicago Press. | en_HK |
dc.subject.mesh | Hepatitis b virus - drug effects - genetics | en_HK |
dc.subject.mesh | Lamivudine - therapeutic use | en_HK |
dc.subject.mesh | Multivariate analysis | en_HK |
dc.subject.mesh | Promoter regions (genetics) | en_HK |
dc.subject.mesh | Serologic tests | en_HK |
dc.title | Prognostic factors in severe exacerbation of chronic hepatitis B | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=36&issue=8&spage=979&epage=984&date=2003&atitle=Prognostic+factors+in+severe+exacerbation+of+chronic+hepatitis+B | en_HK |
dc.identifier.email | Yuen, MF: mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, DKH: danywong@hku.hk | en_HK |
dc.identifier.email | Wong, BCY: bcywong@hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.identifier.authority | Wong, DKH=rp00492 | en_HK |
dc.identifier.authority | Wong, BCY=rp00429 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1086/374226 | en_HK |
dc.identifier.pmid | 12684909 | - |
dc.identifier.scopus | eid_2-s2.0-0037447201 | en_HK |
dc.identifier.hkuros | 77828 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037447201&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 36 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 979 | en_HK |
dc.identifier.epage | 984 | en_HK |
dc.identifier.isi | WOS:000182124700007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.scopusauthorid | Sablon, E=6603694538 | en_HK |
dc.identifier.scopusauthorid | Hui, CK=7202876933 | en_HK |
dc.identifier.scopusauthorid | Li, TM=7406375213 | en_HK |
dc.identifier.scopusauthorid | Yuan, HJ=7402446707 | en_HK |
dc.identifier.scopusauthorid | Wong, DKH=7401535819 | en_HK |
dc.identifier.scopusauthorid | Doutreloigne, J=6603727456 | en_HK |
dc.identifier.scopusauthorid | Bogaerts, V=12787322000 | en_HK |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.issnl | 1058-4838 | - |