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Article: Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

TitleGlobal fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
Authors
Bhattacharjee, Natalia V.Schumacher, Austin E.Aali, AmiraliAbate, Yohannes HabtegiorgisAbbasgholizadeh, RouzbehAbbasian, MohammadrezaAbbasi-Kangevari, MohsenAbbastabar, HedayatElHafeez, Samar AbdAbd-Elsalam, SheriefAbdollahi, MohammadAbdollahifar, Mohammad AminAbdoun, MeriemAbdullahi, AuwalAbebe, MesfinAbebe, Samrawit ShawelAbiodun, OlumideAbolhassani, HassanAbolmaali, MeysamAbouzid, MohamedAboye, Girma BeressaAbreu, Lucas GuimarãesAbrha, Woldu AberheAbrigo, Michael R.M.Abtahi, DariushAbualruz, HasanAbubakar, BilyaminuAbu-Gharbieh, EmanAbu-Rmeileh, Niveen M.E.Adal, Tadele Girum GirumAdane, Mesafint MollaAdeagbo, Oluwafemi Atanda AdeagboAdedoyin, Rufus AdesojiAdekanmbi, VictorAden, BashirAdepoju, Abiola VictorAdetokunboh, Olatunji O.Adetunji, Juliana BunmiAdeyinka, Daniel AdedayoAdeyomoye, Olorunsola IsraelAdnani, Qorinah Estiningtyas SakilahAdra, SaryiaAfolabi, Rotimi FelixAfyouni, ShadiAfzal, Muhammad SohailAfzal, SairaAghamiri, ShahinAgodi, AntonellaAgyemang-Duah, WilliamsAhinkorah, Bright OpokuAhlstrom, Austin J.Ahmad, AqeelAhmad, DanishAhmad, FirdosAhmad, Muayyad M.Ahmad, SajjadAhmad, TauseefAhmed, AliAhmed, AymanAhmed, HaroonAhmed, Luai A.Ahmed, Meqdad SalehAhmed, Syed AneesAjami, MarjanAji, BudiAkalu, Gizachew TaddesseAkbarialiabad, HosseinAkinyemi, Rufus OlusolaAkkaif, Mohammed AhmedAkkala, SreelathaAl Hamad, HanadiAl Hasan, Syed MahfuzQadire, Mohammad AlAL-Ahdal, Tareq Mohammed AliAlalalmeh, Samer O.Alalwan, Tariq A.Al-Aly, ZiyadAlam, KhurshidAl-Amer, Rasmieh MustafaAlanezi, Fahad MashhourAlanzi, Turki M.Albakri, AlmazaAlbashtawy, MohammedAlBataineh, Mohammad T.Alemi, HediyehAlemi, SharifullahAlemu, Yihun MulugetaAl-Eyadhy, AymanAl-Gheethi, Adel Ali SaeedAlhabib, Khalid F.Alhajri, NooraAlhalaiqa, Fadwa Alhalaiqa NajiAlhassan, Robert KabaAli, AbidAli, Beriwan AbdulqadirAli, LiaqatAli, Mohammed UsmanAli, RafatAli, Syed Shujait ShujaitAlif, Sheikh MohammadAligol, MohammadAlijanzadeh, MehranAljasir, Mohammad A.M.Aljunid, Syed MohamedAl-Marwani, SabahAlmazan, Joseph UyAl-Mekhlafi, Hesham M.Almidani, OmarAlomari, Mahmoud A.Al-Omari, BasemAlqahtani, Jaber S.Alqutaibi, Ahmed YaseenAl-Raddadi, Rajaa M.Al-Sabah, Salman KhalifahAltaf, AwaisAl-Tawfiq, Jaffar A.Altirkawi, Khalid A.Aluh, Deborah OyineAlvi, Farrukh JawadAlvis-Guzman, NelsonAlwafi, HassanAl-Worafi, Yaser MohammedAly, HanyAly, SafwatAlzoubi, Karem H.Ameyaw, Edward KwabenaAmin, Tarek TawfikAmindarolzarbi, AlirezaAmini-Rarani, MostafaAmiri, SohrabAmpomah, Irene GyamfuahAmugsi, Dickson A.Amusa, Ganiyu AdeniyiAncuceanu, RobertAnderlini, DeannaAndrade, Pedro PrataAndrei, Catalina LilianaAndrei, TudorelAnil, AbhishekAnil, SnehaAnsar, AdnanAnsari-Moghaddam, AlirezaAntony, Catherine M.Antriyandarti, ErnoizAnvari, SaeidAnwar, SalehaAnwer, RaziqueAnyasodor, Anayochukwu EdwardArabloo, JalalBahri, Razman ArabzadehArafa, Elshaimaa A.Arafat, MosabAraujo, Ana MargaridaAravkin, Aleksandr Y.Aremu, AbdulfataiAripov, TimurArkew, MesayArmocida, BenedettaÄrnlöv, JohanArooj, MahwishArtamonov, Anton A.Arulappan, JudieAruleba, Raphael TaiwoArumugam, AshokanAsadi-Lari, MohsenAsemi, ZatollahAsgary, SaeedAsghariahmadabad, MonaAsghari-Jafarabadi, MohammadAshemo, Mubarek YesseAshraf, MuhammadAshraf, TahiraAsika, Marvellous O.Athari, Seyyed ShamsadinAtout, Maha Moh d.WahbiAtreya, AlokAujayeb, AvinashAusloos, MarcelAvan, AbolfazlAweke, Amlaku MulatAyele, Getnet MelakuAyyoubzadeh, Seyed MohammadAzadnajafabad, SinaAzevedo, Rui M.S.Azzam, Ahmed Y.Badar, MuhammadBadiye, Ashish D.Baghdadi, SoroushBagheri, NasserBagherieh, SaraBahmanziari, NajmehBai, RuhaiBaig, Atif AminBaker, Jennifer L.Bako, Abdulaziz T.Bakshi, Ravleen KaurBalasubramanian, MadhanBaltatu, Ovidiu ConstantinBam, KiranBanach, MacIejBandyopadhyay, SohamBanik, BiswajitBanik, Palash ChandraBansal, HansiBaran, Mehmet FiratBarchitta, MartinaBardhan, MainakBardideh, ErfanBarker-Collo, Suzanne LynBärnighausen, Till WinfriedBarone-Adesi, FrancescoBarqawi, Hiba JawdatBarrow, AmadouBarteit, SandraBasharat, ZarrinBashir, Asma'u I.J.Bashiru, Hameed AkandeBasiru, AfisuBasso, Joao DiogoBasu, SanjayBatiha, Abdul Monim MohammadBatra, KavitaBaune, Bernhard T.Bayati, MohsenBegum, TahminaBehboudi, EmadBehnoush, Amir HosseinBeiranvand, MaryamRamirez, Diana Fernanda BejaranoBekele, AlehegnBelay, Sefealem AssefaBelgaumi, Uzma IqbalBell, Michelle L.Bello, Olorunjuwon OmolajaBeloukas, ApostolosBensenor, Isabela M.Berezvai, ZomborBerhie, Alemshet YirgaBermudez, Amiel Nazer C.Bettencourt, Paulo J.G.Bhagavathula, Akshaya SrikanthBhardwaj, NikhaBhardwaj, PankajBhardwaj, Prarthna V.Bhaskar, SonuBhat, VivekBhatti, Gurjit KaurBhatti, Jasvinder SinghBhatti, Manpreet S.Bhatti, RajbirBiondi, AntonioBisignano, CatherineBiswas, AtanuBiswas, Raaj KishoreBitra, Veera R.Bjørge, ToneBliss, ElyeBoachie, Micheal KofiBobirca, Anca VasilicaBodolica, VirginiaBodunrin, Aadam OlalekanBogale, Eyob KetemaBogale, Kassawmar AngawHashemi, Milad BonakdarBasara, Berrak BoraBouaoud, SouadBraithwaite, DejanaBrauer, MichaelBreitborde, Nicholas J.K.Bryazka, DanaBulamu, Norma B.Buonsenso, DaniloBurkart, KatrinBurns, Richard A.Bustanji, YasserButt, Nadeem ShafiqueButt, Zahid A.Dos Santos, Florentino Luciano CaetanoCalina, DanielaCampos-Nonato, Ismael R.Cao, FanCao, ShujinCapodici, AngeloCarreras, GiuliaCarugno, AndreaCastañeda-Orjuela, Carlos A.Castelpietra, GiulioCattaruzza, Maria SofiaCaye, ArthurCegolon, LucaCembranel, FrancieliCerin, EsterChadwick, JoshuaChahine, YaacoubChakraborty, ChiranjibChalek, JulianChan, Jeffrey Shi KaiCharalampous, PeriklisChattu, Vijay KumarChaturvedi, SarikaChavula, Malizgani PaulChen, An TianChen, HaoweiChen, SimiaoChi, GeraldChichagi, FatemehChien, Ju HueiChing, Patrick R.Cho, William C.S.Choi, SungchulChong, BryanChopra, HiteshChoudhari, Sonali GajananChristopher, Devasahayam J.Chu, Dinh ToiChukwu, Isaac SundayChung, EricChung, Sheng ChiaCindi, ZinhleCioffi, IolandaCiuffreda, RaffaelaClaro, Rafael M.Coberly, KalebColumbus, AlyssaComfort, HaleyConde, JoaoCriqui, Michael H.Cruz-Martins, NataliaCuadra-Hernández, Silvia MagaliDadana, SriharshaDadras, OmidDahiru, TukurDai, ZhaoliDalton, BronteDamiani, GiovanniDarwesh, Aso MohammadDas, Jai K.Das, SaswatiDashti, MohsenDastiridou, AnnaDávila-Cervantes, Claudio AlbertoDavletov, KairatDebele, Aklilu TamireDebopadhaya, ShayomDelavari, SomayehDelgado-Enciso, IvanDemeke, DessalegnDemessa, Berecha HundessaDeng, XinleiDenova-Gutiérrez, EdgarDeribe, KebedeDervenis, NikolaosDesai, Hardik DineshbhaiDesai, RupakDevanbu, Vinoth Gnana ChellaiyanDhali, ArkadeepDhama, KuldeepDhimal, MeghnathDhulipala, Vishal R.Da Silva, Diana DiasDiaz, DanielDiaz, Michael J.Dima, AdrianaDing, Delaney D.Dirac, M. AshworthDo, Thanh ChiDo, Thao Huynh PhuongDo Prado, Camila BruneliDohare, SushilDong, WanyueD'Oria, MarioDos Santos, Wendel MombaqueDoshmangir, LeilaDowou, Robert KokouDsouza, Ashel ChelseaDsouza, Haneil LarsonDsouza, ViolaDube, JohnDuprey, JoeDuraes, Andre RodriguesDuraisamy, SenbagamDurojaiye, Oyewole ChristopherDutta, SulagnaDwyer-Lindgren, LauraDzianach, Paulina AgnieszkaDziedzic, Arkadiusz MarianEbrahimi, AlirezaEdinur, Hisham AtanEdvardsson, KristinaEfendi, FerryEikemo, Terje AndreasEkholuenetale, MichaelTantawi, Maha ElElemam, Noha MousaadElGohary, Ghada Metwally TawfikElhadi, MuhammedElilo, Legesse TesfayeElmeligy, Omar Abdelsadek AbdouElmonem, Mohamed A.Elshaer, MohammedElsohaby, IbrahimZeydi, Amir EmamiBain, Luchuo EngelbertEskandarieh, ShararehEsposito, FrancescoEstep, KaraEtaee, FarshidFabin, NataliaFagbamigbe, Adeniyi FrancisFahimi, SamanFakhri-Demeshghieh, AliasgharFalzone, LucaFaramarzi, AliFaris, Moez Al Islam Ezzat MahmoudFarmer, SamFaro, AndreFasanmi, Abidemi OmolaraFatehizadeh, AliFauk, Nelsensius KlauFazeli, PooriaFeigin, Valery L.Fereshtehnejad, Seyed MohammadFeroze, Abdullah HamidFerrara, PietroFerreira, NunoFetensa, GetahunFilip, IrinaFischer, FlorianFlavel, JoanneFoigt, Nataliya A.Folayan, Morenike OluwatoyinFomenkov, Artem AlekseevichForoutan, BehzadFoschi, MatteoFowobaje, Kayode RaphaelFrancis, Kate LouiseFreitas, AlbertoFukumoto, TakeshiFuller, John E.Fux, BlimaGaal, Peter AndrasGadanya, Muktar A.Gaidhane, Abhay MotiramjiGalali, YaseenGallus, SilvanoGandhi, Aravind P.Ganesan, BalasankarGaniyani, Mohammad ArfatGarcia-Gordillo, M. 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KirosMirza, MoonisMirzaei, RoyaMishra, AshimMisra, SanjeevMitchell, Philip B.Mittal, ChaitanyaMoazen, BabakMohamed, Abdalla Z.Mohamed, Ahmed IsmailMohamed, JamaMohamed, Mouhand F.H.Mohamed, Nouh SaadMohammad-Alizadeh-Charandabi, SakinehMohammadi, SoheilMohammadian-Hafshejani, AbdollahMohammed, MustaphaMohammed, SalahuddinMohammed, ShafiuMokdad, Ali H.Mokhtarzadehazar, PeymanVardanjani, Hossein MolaviMolinaro, SabrinaMonasta, LorenzoMoni, Mohammad AliMoradi, MaryamMoradi, YousefMoraga, PaulaMoreira, Rafael SilveiraMorovatdar, NegarMorrison, Shane DouglasMorze, JakubMosapour, AbbasMossialos, EliasMotappa, RohithMousavi, ParsaKhaneghah, Amin MousaviMpundu-Kaambwa, ChristineMubarik, SumairaMuccioli, LorenzoMulita, FranceskMunjal, KavitaMurillo-Zamora, EfrenMusa, JonahMusaigwa, FungaiMusina, Ana MariaMuthu, SathishMuthupandian, SaravananMuzaffar, MuhammadMyung, WoojaeNagarajan, Ahamarshan JayaramanNagel, GabrieleNaghavi, PirouzNaik, Ganesh R.Naik, GurudattaNaimzada, Mukhammad DavidNainu, 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Issue Date2024
Citation
Lancet, 2024, v. 403, n. 10440, p. 2057-2099 How to Cite?
AbstractBackground: Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10–54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in habitable areas, and under-5 mortality) were given equal weights, and analyses were conducted utilising the MR-BRT (meta-regression—Bayesian, regularised, trimmed) tool. To capture time-series trends in CCF50 not explained by these covariates, we used a first-order autoregressive model on the residual term. CCF50 as a proportion of each 5-year ASFR was predicted using a linear mixed-effects model with fixed-effects covariates (female educational attainment and contraceptive met need) and random intercepts for geographical regions. Projected TFRs were then computed for each calendar year as the sum of single-year ASFRs across age groups. The reference forecast is our estimate of the most likely fertility future given the model, past fertility, forecasts of covariates, and historical relationships between covariates and fertility. We additionally produced forecasts for multiple alternative scenarios in each location: the UN Sustainable Development Goal (SDG) for education is achieved by 2030; the contraceptive met need SDG is achieved by 2030; pro-natal policies are enacted to create supportive environments for those who give birth; and the previous three scenarios combined. Uncertainty from past data inputs and model estimation was propagated throughout analyses by taking 1000 draws for past and present fertility estimates and 500 draws for future forecasts from the estimated distribution for each metric, with 95% uncertainty intervals (UIs) given as the 2·5 and 97·5 percentiles of the draws. To evaluate the forecasting performance of our model and others, we computed skill values—a metric assessing gain in forecasting accuracy—by comparing predicted versus observed ASFRs from the past 15 years (2007–21). A positive skill metric indicates that the model being evaluated performs better than the baseline model (here, a simplified model holding 2007 values constant in the future), and a negative metric indicates that the evaluated model performs worse than baseline. Findings: During the period from 1950 to 2021, global TFR more than halved, from 4·84 (95% UI 4·63–5·06) to 2·23 (2·09–2·38). Global annual livebirths peaked in 2016 at 142 million (95% UI 137–147), declining to 129 million (121–138) in 2021. Fertility rates declined in all countries and territories since 1950, with TFR remaining above 2·1—canonically considered replacement-level fertility—in 94 (46·1%) countries and territories in 2021. This included 44 of 46 countries in sub-Saharan Africa, which was the super-region with the largest share of livebirths in 2021 (29·2% [28·7–29·6]). 47 countries and territories in which lowest estimated fertility between 1950 and 2021 was below replacement experienced one or more subsequent years with higher fertility; only three of these locations rebounded above replacement levels. Future fertility rates were projected to continue to decline worldwide, reaching a global TFR of 1·83 (1·59–2·08) in 2050 and 1·59 (1·25–1·96) in 2100 under the reference scenario. The number of countries and territories with fertility rates remaining above replacement was forecast to be 49 (24·0%) in 2050 and only six (2·9%) in 2100, with three of these six countries included in the 2021 World Bank-defined low-income group, all located in the GBD super-region of sub-Saharan Africa. The proportion of livebirths occurring in sub-Saharan Africa was forecast to increase to more than half of the world's livebirths in 2100, to 41·3% (39·6–43·1) in 2050 and 54·3% (47·1–59·5) in 2100. The share of livebirths was projected to decline between 2021 and 2100 in most of the six other super-regions—decreasing, for example, in south Asia from 24·8% (23·7–25·8) in 2021 to 16·7% (14·3–19·1) in 2050 and 7·1% (4·4–10·1) in 2100—but was forecast to increase modestly in the north Africa and Middle East and high-income super-regions. Forecast estimates for the alternative combined scenario suggest that meeting SDG targets for education and contraceptive met need, as well as implementing pro-natal policies, would result in global TFRs of 1·65 (1·40–1·92) in 2050 and 1·62 (1·35–1·95) in 2100. The forecasting skill metric values for the IHME model were positive across all age groups, indicating that the model is better than the constant prediction. Interpretation: Fertility is declining globally, with rates in more than half of all countries and territories in 2021 below replacement level. Trends since 2000 show considerable heterogeneity in the steepness of declines, and only a small number of countries experienced even a slight fertility rebound after their lowest observed rate, with none reaching replacement level. Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. Future fertility rates will continue to decline worldwide and will remain low even under successful implementation of pro-natal policies. These changes will have far-reaching economic and societal consequences due to ageing populations and declining workforces in higher-income countries, combined with an increasing share of livebirths among the already poorest regions of the world. Funding: Bill & Melinda Gates Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/361793
ISSN
2023 Impact Factor: 98.4
2023 SCImago Journal Rankings: 12.113

 

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dc.contributor.authorAraujo, Ana Margarida-
dc.contributor.authorAravkin, Aleksandr Y.-
dc.contributor.authorAremu, Abdulfatai-
dc.contributor.authorAripov, Timur-
dc.contributor.authorArkew, Mesay-
dc.contributor.authorArmocida, Benedetta-
dc.contributor.authorÄrnlöv, Johan-
dc.contributor.authorArooj, Mahwish-
dc.contributor.authorArtamonov, Anton A.-
dc.contributor.authorArulappan, Judie-
dc.contributor.authorAruleba, Raphael Taiwo-
dc.contributor.authorArumugam, Ashokan-
dc.contributor.authorAsadi-Lari, Mohsen-
dc.contributor.authorAsemi, Zatollah-
dc.contributor.authorAsgary, Saeed-
dc.contributor.authorAsghariahmadabad, Mona-
dc.contributor.authorAsghari-Jafarabadi, Mohammad-
dc.contributor.authorAshemo, Mubarek Yesse-
dc.contributor.authorAshraf, Muhammad-
dc.contributor.authorAshraf, Tahira-
dc.contributor.authorAsika, Marvellous O.-
dc.contributor.authorAthari, Seyyed Shamsadin-
dc.contributor.authorAtout, Maha Moh d.Wahbi-
dc.contributor.authorAtreya, Alok-
dc.contributor.authorAujayeb, Avinash-
dc.contributor.authorAusloos, Marcel-
dc.contributor.authorAvan, Abolfazl-
dc.contributor.authorAweke, Amlaku Mulat-
dc.contributor.authorAyele, Getnet Melaku-
dc.contributor.authorAyyoubzadeh, Seyed Mohammad-
dc.contributor.authorAzadnajafabad, Sina-
dc.contributor.authorAzevedo, Rui M.S.-
dc.contributor.authorAzzam, Ahmed Y.-
dc.contributor.authorBadar, Muhammad-
dc.contributor.authorBadiye, Ashish D.-
dc.contributor.authorBaghdadi, Soroush-
dc.contributor.authorBagheri, Nasser-
dc.contributor.authorBagherieh, Sara-
dc.contributor.authorBahmanziari, Najmeh-
dc.contributor.authorBai, Ruhai-
dc.contributor.authorBaig, Atif Amin-
dc.contributor.authorBaker, Jennifer L.-
dc.contributor.authorBako, Abdulaziz T.-
dc.contributor.authorBakshi, Ravleen Kaur-
dc.contributor.authorBalasubramanian, Madhan-
dc.contributor.authorBaltatu, Ovidiu Constantin-
dc.contributor.authorBam, Kiran-
dc.contributor.authorBanach, MacIej-
dc.contributor.authorBandyopadhyay, Soham-
dc.contributor.authorBanik, Biswajit-
dc.contributor.authorBanik, Palash Chandra-
dc.contributor.authorBansal, Hansi-
dc.contributor.authorBaran, Mehmet Firat-
dc.contributor.authorBarchitta, Martina-
dc.contributor.authorBardhan, Mainak-
dc.contributor.authorBardideh, Erfan-
dc.contributor.authorBarker-Collo, Suzanne Lyn-
dc.contributor.authorBärnighausen, Till Winfried-
dc.contributor.authorBarone-Adesi, Francesco-
dc.contributor.authorBarqawi, Hiba Jawdat-
dc.contributor.authorBarrow, Amadou-
dc.contributor.authorBarteit, Sandra-
dc.contributor.authorBasharat, Zarrin-
dc.contributor.authorBashir, Asma'u I.J.-
dc.contributor.authorBashiru, Hameed Akande-
dc.contributor.authorBasiru, Afisu-
dc.contributor.authorBasso, Joao Diogo-
dc.contributor.authorBasu, Sanjay-
dc.contributor.authorBatiha, Abdul Monim Mohammad-
dc.contributor.authorBatra, Kavita-
dc.contributor.authorBaune, Bernhard T.-
dc.contributor.authorBayati, Mohsen-
dc.contributor.authorBegum, Tahmina-
dc.contributor.authorBehboudi, Emad-
dc.contributor.authorBehnoush, Amir Hossein-
dc.contributor.authorBeiranvand, Maryam-
dc.contributor.authorRamirez, Diana Fernanda Bejarano-
dc.contributor.authorBekele, Alehegn-
dc.contributor.authorBelay, Sefealem Assefa-
dc.contributor.authorBelgaumi, Uzma Iqbal-
dc.contributor.authorBell, Michelle L.-
dc.contributor.authorBello, Olorunjuwon Omolaja-
dc.contributor.authorBeloukas, Apostolos-
dc.contributor.authorBensenor, Isabela M.-
dc.contributor.authorBerezvai, Zombor-
dc.contributor.authorBerhie, Alemshet Yirga-
dc.contributor.authorBermudez, Amiel Nazer C.-
dc.contributor.authorBettencourt, Paulo J.G.-
dc.contributor.authorBhagavathula, Akshaya Srikanth-
dc.contributor.authorBhardwaj, Nikha-
dc.contributor.authorBhardwaj, Pankaj-
dc.contributor.authorBhardwaj, Prarthna V.-
dc.contributor.authorBhaskar, Sonu-
dc.contributor.authorBhat, Vivek-
dc.contributor.authorBhatti, Gurjit Kaur-
dc.contributor.authorBhatti, Jasvinder Singh-
dc.contributor.authorBhatti, Manpreet S.-
dc.contributor.authorBhatti, Rajbir-
dc.contributor.authorBiondi, Antonio-
dc.contributor.authorBisignano, Catherine-
dc.contributor.authorBiswas, Atanu-
dc.contributor.authorBiswas, Raaj Kishore-
dc.contributor.authorBitra, Veera R.-
dc.contributor.authorBjørge, Tone-
dc.contributor.authorBliss, Elye-
dc.contributor.authorBoachie, Micheal Kofi-
dc.contributor.authorBobirca, Anca Vasilica-
dc.contributor.authorBodolica, Virginia-
dc.contributor.authorBodunrin, Aadam Olalekan-
dc.contributor.authorBogale, Eyob Ketema-
dc.contributor.authorBogale, Kassawmar Angaw-
dc.contributor.authorHashemi, Milad Bonakdar-
dc.contributor.authorBasara, Berrak Bora-
dc.contributor.authorBouaoud, Souad-
dc.contributor.authorBraithwaite, Dejana-
dc.contributor.authorBrauer, Michael-
dc.contributor.authorBreitborde, Nicholas J.K.-
dc.contributor.authorBryazka, Dana-
dc.contributor.authorBulamu, Norma B.-
dc.contributor.authorBuonsenso, Danilo-
dc.contributor.authorBurkart, Katrin-
dc.contributor.authorBurns, Richard A.-
dc.contributor.authorBustanji, Yasser-
dc.contributor.authorButt, Nadeem Shafique-
dc.contributor.authorButt, Zahid A.-
dc.contributor.authorDos Santos, Florentino Luciano Caetano-
dc.contributor.authorCalina, Daniela-
dc.contributor.authorCampos-Nonato, Ismael R.-
dc.contributor.authorCao, Fan-
dc.contributor.authorCao, Shujin-
dc.contributor.authorCapodici, Angelo-
dc.contributor.authorCarreras, Giulia-
dc.contributor.authorCarugno, Andrea-
dc.contributor.authorCastañeda-Orjuela, Carlos A.-
dc.contributor.authorCastelpietra, Giulio-
dc.contributor.authorCattaruzza, Maria Sofia-
dc.contributor.authorCaye, Arthur-
dc.contributor.authorCegolon, Luca-
dc.contributor.authorCembranel, Francieli-
dc.contributor.authorCerin, Ester-
dc.contributor.authorChadwick, Joshua-
dc.contributor.authorChahine, Yaacoub-
dc.contributor.authorChakraborty, Chiranjib-
dc.contributor.authorChalek, Julian-
dc.contributor.authorChan, Jeffrey Shi Kai-
dc.contributor.authorCharalampous, Periklis-
dc.contributor.authorChattu, Vijay Kumar-
dc.contributor.authorChaturvedi, Sarika-
dc.contributor.authorChavula, Malizgani Paul-
dc.contributor.authorChen, An Tian-
dc.contributor.authorChen, Haowei-
dc.contributor.authorChen, Simiao-
dc.contributor.authorChi, Gerald-
dc.contributor.authorChichagi, Fatemeh-
dc.contributor.authorChien, Ju Huei-
dc.contributor.authorChing, Patrick R.-
dc.contributor.authorCho, William C.S.-
dc.contributor.authorChoi, Sungchul-
dc.contributor.authorChong, Bryan-
dc.contributor.authorChopra, Hitesh-
dc.contributor.authorChoudhari, Sonali Gajanan-
dc.contributor.authorChristopher, Devasahayam J.-
dc.contributor.authorChu, Dinh Toi-
dc.contributor.authorChukwu, Isaac Sunday-
dc.contributor.authorChung, Eric-
dc.contributor.authorChung, Sheng Chia-
dc.contributor.authorCindi, Zinhle-
dc.contributor.authorCioffi, Iolanda-
dc.contributor.authorCiuffreda, Raffaela-
dc.contributor.authorClaro, Rafael M.-
dc.contributor.authorCoberly, Kaleb-
dc.contributor.authorColumbus, Alyssa-
dc.contributor.authorComfort, Haley-
dc.contributor.authorConde, Joao-
dc.contributor.authorCriqui, Michael H.-
dc.contributor.authorCruz-Martins, Natalia-
dc.contributor.authorCuadra-Hernández, Silvia Magali-
dc.contributor.authorDadana, Sriharsha-
dc.contributor.authorDadras, Omid-
dc.contributor.authorDahiru, Tukur-
dc.contributor.authorDai, Zhaoli-
dc.contributor.authorDalton, Bronte-
dc.contributor.authorDamiani, Giovanni-
dc.contributor.authorDarwesh, Aso Mohammad-
dc.contributor.authorDas, Jai K.-
dc.contributor.authorDas, Saswati-
dc.contributor.authorDashti, Mohsen-
dc.contributor.authorDastiridou, Anna-
dc.contributor.authorDávila-Cervantes, Claudio Alberto-
dc.contributor.authorDavletov, Kairat-
dc.contributor.authorDebele, Aklilu Tamire-
dc.contributor.authorDebopadhaya, Shayom-
dc.contributor.authorDelavari, Somayeh-
dc.contributor.authorDelgado-Enciso, Ivan-
dc.contributor.authorDemeke, Dessalegn-
dc.contributor.authorDemessa, Berecha Hundessa-
dc.contributor.authorDeng, Xinlei-
dc.contributor.authorDenova-Gutiérrez, Edgar-
dc.contributor.authorDeribe, Kebede-
dc.contributor.authorDervenis, Nikolaos-
dc.contributor.authorDesai, Hardik Dineshbhai-
dc.contributor.authorDesai, Rupak-
dc.contributor.authorDevanbu, Vinoth Gnana Chellaiyan-
dc.contributor.authorDhali, Arkadeep-
dc.contributor.authorDhama, Kuldeep-
dc.contributor.authorDhimal, Meghnath-
dc.contributor.authorDhulipala, Vishal R.-
dc.contributor.authorDa Silva, Diana Dias-
dc.contributor.authorDiaz, Daniel-
dc.contributor.authorDiaz, Michael J.-
dc.contributor.authorDima, Adriana-
dc.contributor.authorDing, Delaney D.-
dc.contributor.authorDirac, M. Ashworth-
dc.contributor.authorDo, Thanh Chi-
dc.contributor.authorDo, Thao Huynh Phuong-
dc.contributor.authorDo Prado, Camila Bruneli-
dc.contributor.authorDohare, Sushil-
dc.contributor.authorDong, Wanyue-
dc.contributor.authorD'Oria, Mario-
dc.contributor.authorDos Santos, Wendel Mombaque-
dc.contributor.authorDoshmangir, Leila-
dc.contributor.authorDowou, Robert Kokou-
dc.contributor.authorDsouza, Ashel Chelsea-
dc.contributor.authorDsouza, Haneil Larson-
dc.contributor.authorDsouza, Viola-
dc.contributor.authorDube, John-
dc.contributor.authorDuprey, Joe-
dc.contributor.authorDuraes, Andre Rodrigues-
dc.contributor.authorDuraisamy, Senbagam-
dc.contributor.authorDurojaiye, Oyewole Christopher-
dc.contributor.authorDutta, Sulagna-
dc.contributor.authorDwyer-Lindgren, Laura-
dc.contributor.authorDzianach, Paulina Agnieszka-
dc.contributor.authorDziedzic, Arkadiusz Marian-
dc.contributor.authorEbrahimi, Alireza-
dc.contributor.authorEdinur, Hisham Atan-
dc.contributor.authorEdvardsson, Kristina-
dc.contributor.authorEfendi, Ferry-
dc.contributor.authorEikemo, Terje Andreas-
dc.contributor.authorEkholuenetale, Michael-
dc.contributor.authorTantawi, Maha El-
dc.contributor.authorElemam, Noha Mousaad-
dc.contributor.authorElGohary, Ghada Metwally Tawfik-
dc.contributor.authorElhadi, Muhammed-
dc.contributor.authorElilo, Legesse Tesfaye-
dc.contributor.authorElmeligy, Omar Abdelsadek Abdou-
dc.contributor.authorElmonem, Mohamed A.-
dc.contributor.authorElshaer, Mohammed-
dc.contributor.authorElsohaby, Ibrahim-
dc.contributor.authorZeydi, Amir Emami-
dc.contributor.authorBain, Luchuo Engelbert-
dc.contributor.authorEskandarieh, Sharareh-
dc.contributor.authorEsposito, Francesco-
dc.contributor.authorEstep, Kara-
dc.contributor.authorEtaee, Farshid-
dc.contributor.authorFabin, Natalia-
dc.contributor.authorFagbamigbe, Adeniyi Francis-
dc.contributor.authorFahimi, Saman-
dc.contributor.authorFakhri-Demeshghieh, Aliasghar-
dc.contributor.authorFalzone, Luca-
dc.contributor.authorFaramarzi, Ali-
dc.contributor.authorFaris, Moez Al Islam Ezzat Mahmoud-
dc.contributor.authorFarmer, Sam-
dc.contributor.authorFaro, Andre-
dc.contributor.authorFasanmi, Abidemi Omolara-
dc.contributor.authorFatehizadeh, Ali-
dc.contributor.authorFauk, Nelsensius Klau-
dc.contributor.authorFazeli, Pooria-
dc.contributor.authorFeigin, Valery L.-
dc.contributor.authorFereshtehnejad, Seyed Mohammad-
dc.contributor.authorFeroze, Abdullah Hamid-
dc.contributor.authorFerrara, Pietro-
dc.contributor.authorFerreira, Nuno-
dc.contributor.authorFetensa, Getahun-
dc.contributor.authorFilip, Irina-
dc.contributor.authorFischer, Florian-
dc.contributor.authorFlavel, Joanne-
dc.contributor.authorFoigt, Nataliya A.-
dc.contributor.authorFolayan, Morenike Oluwatoyin-
dc.contributor.authorFomenkov, Artem Alekseevich-
dc.contributor.authorForoutan, Behzad-
dc.contributor.authorFoschi, Matteo-
dc.contributor.authorFowobaje, Kayode Raphael-
dc.contributor.authorFrancis, Kate Louise-
dc.contributor.authorFreitas, Alberto-
dc.contributor.authorFukumoto, Takeshi-
dc.contributor.authorFuller, John E.-
dc.contributor.authorFux, Blima-
dc.contributor.authorGaal, Peter Andras-
dc.contributor.authorGadanya, Muktar A.-
dc.contributor.authorGaidhane, Abhay Motiramji-
dc.contributor.authorGalali, Yaseen-
dc.contributor.authorGallus, Silvano-
dc.contributor.authorGandhi, Aravind P.-
dc.contributor.authorGanesan, Balasankar-
dc.contributor.authorGaniyani, Mohammad Arfat-
dc.contributor.authorGarcia-Gordillo, M. A.-
dc.contributor.authorGarg, Naval-
dc.contributor.authorGautam, Rupesh K.-
dc.contributor.authorGazzelloni, Federica-
dc.contributor.authorGbadamosi, Semiu Olatunde-
dc.contributor.authorGebregergis, Miglas W.-
dc.contributor.authorGebrehiwot, Mesfin-
dc.contributor.authorGebremariam, Tesfay B.B.-
dc.contributor.authorGebremeskel, Teferi Gebru-
dc.contributor.authorGeda, Yohannes Fikadu-
dc.contributor.authorGeorgescu, Simona Roxana-
dc.contributor.authorGerema, Urge-
dc.contributor.authorGeremew, Habtamu-
dc.contributor.authorGetachew, Motuma Erena-
dc.contributor.authorGething, Peter W.-
dc.contributor.authorGhasemi, Mohammad Reza-
dc.contributor.authorDabaghi, Ghazal Ghasempour-
dc.contributor.authorGhasemzadeh, Afsaneh-
dc.contributor.authorGhassemi, Fariba-
dc.contributor.authorGhazy, Ramy Mohamed-
dc.contributor.authorGhimire, Sailaja-
dc.contributor.authorGholamian, Asadollah-
dc.contributor.authorGholamrezanezhad, Ali-
dc.contributor.authorGhorbani, Mahsa-
dc.contributor.authorGhoshal, Aloke Gopal-
dc.contributor.authorGhuge, Arun Digambarrao-
dc.contributor.authorGil, Artyom Urievich-
dc.contributor.authorGill, Tiffany K.-
dc.contributor.authorGiorgi, Matteo-
dc.contributor.authorGirmay, Alem-
dc.contributor.authorGlasbey, James C.-
dc.contributor.authorGöbölös, Laszlo-
dc.contributor.authorGoel, Amit-
dc.contributor.authorGolchin, Ali-
dc.contributor.authorGolechha, Mahaveer-
dc.contributor.authorGoleij, Pouya-
dc.contributor.authorGopalani, Sameer Vali-
dc.contributor.authorGoudarzi, Houman-
dc.contributor.authorGoulart, Alessandra C.-
dc.contributor.authorGoyal, Anmol-
dc.contributor.authorGraham, Simon Matthew-
dc.contributor.authorGrivna, Michal-
dc.contributor.authorGuan, Shi Yang-
dc.contributor.authorGuarducci, Giovanni-
dc.contributor.authorGubari, Mohammed Ibrahim Mohialdeen-
dc.contributor.authorGudeta, Mesay Dechasa-
dc.contributor.authorGuicciardi, Stefano-
dc.contributor.authorGulati, Snigdha-
dc.contributor.authorGulisashvili, David-
dc.contributor.authorGunawardane, Damitha Asanga-
dc.contributor.authorGuo, Cui-
dc.contributor.authorGupta, Anish Kumar-
dc.contributor.authorGupta, Bhawna-
dc.contributor.authorGupta, Manoj Kumar-
dc.contributor.authorGupta, Mohak-
dc.contributor.authorGupta, Sapna-
dc.contributor.authorGupta, Veer Bala-
dc.contributor.authorGupta, Vijai Kumar-
dc.contributor.authorGupta, Vivek Kumar-
dc.contributor.authorHaakenstad, Annie-
dc.contributor.authorHabibzadeh, Farrokh-
dc.contributor.authorHadi, Najah R.-
dc.contributor.authorHaep, Nils-
dc.contributor.authorHajibeygi, Ramtin-
dc.contributor.authorHaller, Sebastian-
dc.contributor.authorHalwani, Rabih-
dc.contributor.authorHamadeh, Randah R.-
dc.contributor.authorHamdy, Nadia M.-
dc.contributor.authorHameed, Sajid-
dc.contributor.authorHamidi, Samer-
dc.contributor.authorHan, Qiuxia-
dc.contributor.authorHandal, Alexis J.-
dc.contributor.authorHankey, Graeme J.-
dc.contributor.authorHaque, Md Nuruzzaman-
dc.contributor.authorHaro, Josep Maria-
dc.contributor.authorHasaballah, Ahmed I.-
dc.contributor.authorHasan, Ikramul-
dc.contributor.authorHasan, Mohammad Jahid-
dc.contributor.authorMahmudul Hasan, S. M.-
dc.contributor.authorHasani, Hamidreza-
dc.contributor.authorHasnain, Md Saquib-
dc.contributor.authorHassan, Amr-
dc.contributor.authorHassan, Ikrama-
dc.contributor.authorHassanipour, Soheil-
dc.contributor.authorHassankhani, Hadi-
dc.contributor.authorHay, Simon I.-
dc.contributor.authorHebert, Jeffrey J.-
dc.contributor.authorHegazi, Omar E.-
dc.contributor.authorHeidari, Mohammad-
dc.contributor.authorHelfer, Bartosz-
dc.contributor.authorHemmati, Mehdi-
dc.contributor.authorHerrera-Serna, Brenda Yuliana-
dc.contributor.authorHerteliu, Claudiu-
dc.contributor.authorHessami, Kamran-
dc.contributor.authorHezam, Kamal-
dc.contributor.authorHiraike, Yuta-
dc.contributor.authorHoan, Nguyen Quoc-
dc.contributor.authorHolla, Ramesh-
dc.contributor.authorHorita, Nobuyuki-
dc.contributor.authorHossain, Md Mahbub-
dc.contributor.authorHossain, Mohammad Bellal Hossain-
dc.contributor.authorHosseinzadeh, Hassan-
dc.contributor.authorHosseinzadeh, Mehdi-
dc.contributor.authorHostiuc, Mihaela-
dc.contributor.authorHostiuc, Sorin-
dc.contributor.authorHsairi, Mohamed-
dc.contributor.authorHsieh, Vivian Chia Rong-
dc.contributor.authorHu, Chengxi-
dc.contributor.authorHuang, Junjie-
dc.contributor.authorHuda, M. Mamun-
dc.contributor.authorHumayun, Ayesha-
dc.contributor.authorHussain, Javid-
dc.contributor.authorHussein, Nawfal R.-
dc.contributor.authorHuynh, Hong Han-
dc.contributor.authorHwang, Bing Fang-
dc.contributor.authorIbitoye, Segun Emmanuel-
dc.contributor.authorIftikhar, Pulwasha Maria-
dc.contributor.authorIlesanmi, Olayinka Stephen-
dc.contributor.authorIlic, Irena M.-
dc.contributor.authorIlic, Milena D.-
dc.contributor.authorImmurana, Mustapha-
dc.contributor.authorInbaraj, Leeberk Raja-
dc.contributor.authorIqbal, Afrin-
dc.contributor.authorIslam, Md Rabiul-
dc.contributor.authorIsmail, Nahlah Elkudssiah-
dc.contributor.authorIso, Hiroyasu-
dc.contributor.authorIsola, Gaetano-
dc.contributor.authorIwagami, Masao-
dc.contributor.authorIyer, Mahalaxmi-
dc.contributor.authorLinda Merin, J.-
dc.contributor.authorJaafari, Jalil-
dc.contributor.authorJacob, Louis-
dc.contributor.authorJadidi-Niaragh, Farhad-
dc.contributor.authorJaggi, Khushleen-
dc.contributor.authorJahankhani, Kasra-
dc.contributor.authorJahanmehr, Nader-
dc.contributor.authorJahrami, Haitham-
dc.contributor.authorJain, Akhil-
dc.contributor.authorJain, Nityanand-
dc.contributor.authorJairoun, Ammar Abdulrahman-
dc.contributor.authorJakovljevic, Mihajlo-
dc.contributor.authorJamshidi, Elham-
dc.contributor.authorJavadov, Sabzali-
dc.contributor.authorJavaheri, Tahereh-
dc.contributor.authorJayapal, Sathish Kumar-
dc.contributor.authorJayaram, Shubha-
dc.contributor.authorJee, Sun Ha-
dc.contributor.authorJeganathan, Jayakumar-
dc.contributor.authorJha, Anil K.-
dc.contributor.authorJha, Ravi Prakash-
dc.contributor.authorJiang, Heng-
dc.contributor.authorJokar, Mohammad-
dc.contributor.authorJonas, Jost B.-
dc.contributor.authorJoo, Tamas-
dc.contributor.authorJoseph, Nitin-
dc.contributor.authorJoshua, Charity Ehimwenma-
dc.contributor.authorJoukar, Farahnaz-
dc.contributor.authorJozwiak, Jacek Jerzy-
dc.contributor.authorJürisson, Mikk-
dc.contributor.authorVaishali, K.-
dc.contributor.authorKaambwa, Billingsley-
dc.contributor.authorKabir, Abdulkareem-
dc.contributor.authorKabir, Ali-
dc.contributor.authorKabir, Hannaneh-
dc.contributor.authorKabir, Zubair-
dc.contributor.authorKalani, Rizwan-
dc.contributor.authorKalankesh, Leila R.-
dc.contributor.authorKaliyadan, Feroze-
dc.contributor.authorKalra, Sanjay-
dc.contributor.authorKamath, Rajesh-
dc.contributor.authorKamath, Sagarika-
dc.contributor.authorKanchan, Tanuj-
dc.contributor.authorKanmiki, Edmund Wedam-
dc.contributor.authorKanmodi, Kehinde Kazeem-
dc.contributor.authorSuthanthira Kannan, S.-
dc.contributor.authorKansal, Sushil Kumar-
dc.contributor.authorKantar, Rami S.-
dc.contributor.authorKapoor, Neeti-
dc.contributor.authorKarajizadeh, Mehrdad-
dc.contributor.authorKarami, Manoochehr-
dc.contributor.authorKaraye, Ibraheem M.-
dc.contributor.authorKashoo, Faizan Zaffar-
dc.contributor.authorKasraei, Hengameh-
dc.contributor.authorKassebaum, Nicholas J.-
dc.contributor.authorKassel, Molly B.-
dc.contributor.authorKauppila, Joonas H.-
dc.contributor.authorKazemi, Foad-
dc.contributor.authorKazeminia, Sara-
dc.contributor.authorKempen, John H.-
dc.contributor.authorKendal, Evie Shoshannah-
dc.contributor.authorKeshtkar, Kamyab-
dc.contributor.authorKeykhaei, Mohammad-
dc.contributor.authorKhajuria, Himanshu-
dc.contributor.authorKhalaji, Amirmohammad-
dc.contributor.authorKhalid, Nauman-
dc.contributor.authorKhalil, Anees Ahmed-
dc.contributor.authorKhalilian, Alireza-
dc.contributor.authorKhamesipour, Faham-
dc.contributor.authorKhan, Ajmal-
dc.contributor.authorKhan, Asaduzzaman-
dc.contributor.authorKhan, Ikramullah-
dc.contributor.authorKhan, M. Nuruzzaman-
dc.contributor.authorKhan, Maseer-
dc.contributor.authorKhan, Mohammad Jobair-
dc.contributor.authorKhan, Moien A.B.-
dc.contributor.authorKhang, Young Ho-
dc.contributor.authorKhanmohammadi, Shaghayegh-
dc.contributor.authorKhatab, Khaled-
dc.contributor.authorKhavandegar, Armin-
dc.contributor.authorKashani, Hamid Reza Khayat-
dc.contributor.authorKhidri, Feriha Fatima-
dc.contributor.authorKhormali, Moein-
dc.contributor.authorKhosravi, Mohammad Ali-
dc.contributor.authorKhosrowjerdi, Mahmood-
dc.contributor.authorKidane, Wondwosen Teklesilasie-
dc.contributor.authorKifle, Zemene Demelash-
dc.contributor.authorKim, Julie Sojin-
dc.contributor.authorKim, Min Seo-
dc.contributor.authorKimokoti, Ruth W.-
dc.contributor.authorKinzel, Kasey E.-
dc.contributor.authorKiross, Girmay Tsegay-
dc.contributor.authorKisa, Adnan-
dc.contributor.authorKisa, Sezer-
dc.contributor.authorKolahi, Ali Asghar-
dc.contributor.authorKompani, Farzad-
dc.contributor.authorKoren, Gerbrand-
dc.contributor.authorKorzh, Oleksii-
dc.contributor.authorKosen, Soewarta-
dc.contributor.authorLaxminarayana, Sindhura Lakshmi Koulmane-
dc.contributor.authorKrishan, Kewal-
dc.contributor.authorKrishna, Varun-
dc.contributor.authorKrishnamoorthy, Vijay-
dc.contributor.authorDefo, Barthelemy Kuate-
dc.contributor.authorKubeisy, Connor M.-
dc.contributor.authorBicer, Burcu Kucuk-
dc.contributor.authorKuddus, Md Abdul-
dc.contributor.authorKuddus, Mohammed-
dc.contributor.authorKuitunen, Ilari-
dc.contributor.authorKulimbet, Mukhtar-
dc.contributor.authorKumar, Harish-
dc.contributor.authorKundu, Satyajit-
dc.contributor.authorKunle, Kunle Rotimi-
dc.contributor.authorKurmi, Om P.-
dc.contributor.authorKusnali, Asep-
dc.contributor.authorKusuma, Dian-
dc.contributor.authorKyei, Evans F.-
dc.contributor.authorKyriopoulos, Ilias-
dc.contributor.authorVecchia, Carlo La-
dc.contributor.authorLacey, Ben-
dc.contributor.authorLadan, Muhammad Awwal-
dc.contributor.authorLaflamme, Lucie-
dc.contributor.authorLahariya, Chandrakant-
dc.contributor.authorLai, Daphne Teck Ching-
dc.contributor.authorLal, Dharmesh Kumar-
dc.contributor.authorLalloo, Ratilal-
dc.contributor.authorLám, Judit-
dc.contributor.authorLamnisos, Demetris-
dc.contributor.authorLandires, Ivan-
dc.contributor.authorLanfranchi, Francesco-
dc.contributor.authorLangguth, Berthold-
dc.contributor.authorLaplante-Lévesque, Ariane-
dc.contributor.authorLarson, Heidi Jane-
dc.contributor.authorLarsson, Anders O.-
dc.contributor.authorLasrado, Savita-
dc.contributor.authorLatief, Kamaluddin-
dc.contributor.authorLatifinaibin, Kaveh-
dc.contributor.authorLe, Long Khanh Dao-
dc.contributor.authorLe, Nhi Huu Hanh-
dc.contributor.authorLe, Trang Diep Thanh-
dc.contributor.authorLedda, Caterina-
dc.contributor.authorLee, Munjae-
dc.contributor.authorLee, Paul H.-
dc.contributor.authorLee, Seung Won-
dc.contributor.authorLee, Yo Han-
dc.contributor.authorLema, Gebretsadik Kiros-
dc.contributor.authorLeong, Elvynna-
dc.contributor.authorLerango, Temesgen L.-
dc.contributor.authorLi, An-
dc.contributor.authorLi, Ming Chieh-
dc.contributor.authorLi, Shanshan-
dc.contributor.authorLi, Wei-
dc.contributor.authorLi, Xiaopan-
dc.contributor.authorLigade, Virendra S.-
dc.contributor.authorLim, Stephen S.-
dc.contributor.authorLin, Ro Ting-
dc.contributor.authorLindstedt, Paulina A.-
dc.contributor.authorListl, Stefan-
dc.contributor.authorLiu, Gang-
dc.contributor.authorLiu, Jue-
dc.contributor.authorLiu, Xiaofeng-
dc.contributor.authorLiu, Xuefeng-
dc.contributor.authorLiu, Yuewei-
dc.contributor.authorLlanaj, Erand-
dc.contributor.authorLópez-Bueno, Ruben-
dc.contributor.authorLopukhov, Platon D.-
dc.contributor.authorLorenzovici, Laszlo-
dc.contributor.authorLotufo, Paulo A.-
dc.contributor.authorLubinda, Jailos-
dc.contributor.authorLucchetti, Giancarlo-
dc.contributor.authorLugo, Alessandra-
dc.contributor.authorLunevicius, Raimundas-
dc.contributor.authorLv, Hengliang-
dc.contributor.authorMa, Zheng Feei-
dc.contributor.authorMaass, Kelsey Lynn-
dc.contributor.authorMacHoy, Monika-
dc.contributor.authorMadureira-Carvalho, Áurea M.-
dc.contributor.authorEl Razek, Mohammed Magdy Abd-
dc.contributor.authorMaghazachi, Azzam A.-
dc.contributor.authorMahjoub, Soleiman-
dc.contributor.authorMahmoud, Mansour Adam-
dc.contributor.authorMajeed, Azeem-
dc.contributor.authorMalagón-Rojas, Jeadran N.-
dc.contributor.authorRad, Elaheh Malakan-
dc.contributor.authorMalhotra, Kashish-
dc.contributor.authorMalik, Ahmad Azam-
dc.contributor.authorMalik, Iram-
dc.contributor.authorMalta, Deborah Carvalho-
dc.contributor.authorMamun, Abdullah A.-
dc.contributor.authorManla, Yosef-
dc.contributor.authorMansoori, Yasaman-
dc.contributor.authorMansour, Ali-
dc.contributor.authorMansouri, Borhan-
dc.contributor.authorMansouri, Zeinab-
dc.contributor.authorMansournia, Mohammad Ali-
dc.contributor.authorMaravilla, Joemer C.-
dc.contributor.authorMarino, Mirko-
dc.contributor.authorMarjani, Abdoljalal-
dc.contributor.authorMartinez, Gabriel-
dc.contributor.authorMartinez-Piedra, Ramon-
dc.contributor.authorMartins-Melo, Francisco Rogerlandio-
dc.contributor.authorMartorell, Miquel-
dc.contributor.authorMaryam, Sharmeen-
dc.contributor.authorMarzo, Roy Rillera-
dc.contributor.authorMasoudi, Alireza-
dc.contributor.authorMattumpuram, Jishanth-
dc.contributor.authorMaude, Richard James-
dc.contributor.authorMaugeri, Andrea-
dc.contributor.authorMay, Erin A.-
dc.contributor.authorMayeli, Mahsa-
dc.contributor.authorMazaheri, Maryam-
dc.contributor.authorMcGrath, John J.-
dc.contributor.authorMcKee, Martin-
dc.contributor.authorMcKowen, Anna Laura Wensel-
dc.contributor.authorMcLaughlin, Susan A.-
dc.contributor.authorMcPhail, Steven M.-
dc.contributor.authorMehra, Rahul-
dc.contributor.authorMehrabani-Zeinabad, Kamran-
dc.contributor.authorNasab, Entezar Mehrabi-
dc.contributor.authorMeto, Tesfahun Mekene-
dc.contributor.authorMendez-Lopez, Max Alberto Mendez-
dc.contributor.authorMendoza, Walter-
dc.contributor.authorMenezes, Ritesh G.-
dc.contributor.authorMensah, George A.-
dc.contributor.authorMentis, Alexios Fotios A.-
dc.contributor.authorMeo, Sultan Ayoub-
dc.contributor.authorMerati, Mohsen-
dc.contributor.authorMeretoja, Atte-
dc.contributor.authorMeretoja, Tuomo J.-
dc.contributor.authorMersha, Abera M.-
dc.contributor.authorMestrovic, Tomislav-
dc.contributor.authorMetanat, Pouya-
dc.contributor.authorMettananda, Kukulege Chamila Dinushi-
dc.contributor.authorMettananda, Sachith-
dc.contributor.authorMhlanga, Adquate-
dc.contributor.authorMhlanga, Laurette-
dc.contributor.authorMi, Tianyue-
dc.contributor.authorMiazgowski, Tomasz-
dc.contributor.authorMicha, Georgia-
dc.contributor.authorMichalek, Irmina Maria-
dc.contributor.authorMiller, Ted R.-
dc.contributor.authorMinh, Le Huu Nhat-
dc.contributor.authorMirghafourvand, Mojgan-
dc.contributor.authorMirrakhimov, Erkin M.-
dc.contributor.authorMirutse, Mizan Kiros-
dc.contributor.authorMirza, Moonis-
dc.contributor.authorMirzaei, Roya-
dc.contributor.authorMishra, Ashim-
dc.contributor.authorMisra, Sanjeev-
dc.contributor.authorMitchell, Philip B.-
dc.contributor.authorMittal, Chaitanya-
dc.contributor.authorMoazen, Babak-
dc.contributor.authorMohamed, Abdalla Z.-
dc.contributor.authorMohamed, Ahmed Ismail-
dc.contributor.authorMohamed, Jama-
dc.contributor.authorMohamed, Mouhand F.H.-
dc.contributor.authorMohamed, Nouh Saad-
dc.contributor.authorMohammad-Alizadeh-Charandabi, Sakineh-
dc.contributor.authorMohammadi, Soheil-
dc.contributor.authorMohammadian-Hafshejani, Abdollah-
dc.contributor.authorMohammed, Mustapha-
dc.contributor.authorMohammed, Salahuddin-
dc.contributor.authorMohammed, Shafiu-
dc.contributor.authorMokdad, Ali H.-
dc.contributor.authorMokhtarzadehazar, Peyman-
dc.contributor.authorVardanjani, Hossein Molavi-
dc.contributor.authorMolinaro, Sabrina-
dc.contributor.authorMonasta, Lorenzo-
dc.contributor.authorMoni, Mohammad Ali-
dc.contributor.authorMoradi, Maryam-
dc.contributor.authorMoradi, Yousef-
dc.contributor.authorMoraga, Paula-
dc.contributor.authorMoreira, Rafael Silveira-
dc.contributor.authorMorovatdar, Negar-
dc.contributor.authorMorrison, Shane Douglas-
dc.contributor.authorMorze, Jakub-
dc.contributor.authorMosapour, Abbas-
dc.contributor.authorMossialos, Elias-
dc.contributor.authorMotappa, Rohith-
dc.contributor.authorMousavi, Parsa-
dc.contributor.authorKhaneghah, Amin Mousavi-
dc.contributor.authorMpundu-Kaambwa, Christine-
dc.contributor.authorMubarik, Sumaira-
dc.contributor.authorMuccioli, Lorenzo-
dc.contributor.authorMulita, Francesk-
dc.contributor.authorMunjal, Kavita-
dc.contributor.authorMurillo-Zamora, Efren-
dc.contributor.authorMusa, Jonah-
dc.contributor.authorMusaigwa, Fungai-
dc.contributor.authorMusina, Ana Maria-
dc.contributor.authorMuthu, Sathish-
dc.contributor.authorMuthupandian, Saravanan-
dc.contributor.authorMuzaffar, Muhammad-
dc.contributor.authorMyung, Woojae-
dc.contributor.authorNagarajan, Ahamarshan Jayaraman-
dc.contributor.authorNagel, Gabriele-
dc.contributor.authorNaghavi, Pirouz-
dc.contributor.authorNaik, Ganesh R.-
dc.contributor.authorNaik, Gurudatta-
dc.contributor.authorNaimzada, Mukhammad David-
dc.contributor.authorNainu, Firzan-
dc.contributor.authorNangia, Vinay-
dc.contributor.authorSwamy, Sreenivas Narasimha-
dc.contributor.authorNascimento, Bruno Ramos-
dc.contributor.authorNascimento, Gustavo G.-
dc.contributor.authorNaser, Abdallah Y.-
dc.contributor.authorNasiri, Mohammad Javad-
dc.contributor.authorNatto, Zuhair S.-
dc.contributor.authorNauman, Javaid-
dc.contributor.authorNaveed, Muhammad-
dc.contributor.authorNayak, Biswa Prakash-
dc.contributor.authorNayak, Vinod C.-
dc.contributor.authorNdejjo, Rawlance-
dc.contributor.authorNduaguba, Sabina Onyinye-
dc.contributor.authorNegash, Hadush-
dc.contributor.authorNegesse, Chernet Tafere-
dc.contributor.authorNegoi, Ionut-
dc.contributor.authorNegoi, Ruxandra Irina-
dc.contributor.authorNejadghaderi, Seyed Aria-
dc.contributor.authorNejjari, Chakib-
dc.contributor.authorNepal, Samata-
dc.contributor.authorNetsere, Henok Biresaw-
dc.contributor.authorNguefack-Tsague, Georges-
dc.contributor.authorNgunjiri, Josephine W.-
dc.contributor.authorNguyen, Dang H.-
dc.contributor.authorNguyen, Hau Thi Hien-
dc.contributor.authorNguyen, Phuong The-
dc.contributor.authorNguyen, Quynh Anh P.-
dc.contributor.authorNguyen, Van Thanh-
dc.contributor.authorNiazi, Robina Khan-
dc.contributor.authorNigatu, Yeshambel T.-
dc.contributor.authorNikolouzakis, Taxiarchis Konstantinos-
dc.contributor.authorNikoobar, Ali-
dc.contributor.authorNikpoor, Amin Reza-
dc.contributor.authorNnaji, Chukwudi A.-
dc.contributor.authorNnyanzi, Lawrence Achilles-
dc.contributor.authorNoman, Efaq Ali-
dc.contributor.authorNomura, Shuhei-
dc.contributor.authorNoreen, Mamoona-
dc.contributor.authorNoroozi, Nafise-
dc.contributor.authorNri-Ezedi, Chisom Adaobi-
dc.contributor.authorNunemo, Mengistu H.-
dc.contributor.authorNuñez-Samudio, Virginia-
dc.contributor.authorNurrika, Dieta-
dc.contributor.authorNutor, Jerry John-
dc.contributor.authorOancea, Bogdan-
dc.contributor.authorObamiro, Kehinde O.-
dc.contributor.authorOdetokun, Ismail A.-
dc.contributor.authorOdogwu, Nkechi Martina-
dc.contributor.authorO'Donnell, Martin James-
dc.contributor.authorOdukoya, Oluwakemi Ololade-
dc.contributor.authorOguntade, Ayodipupo Sikiru-
dc.contributor.authorOguta, James Odhiambo-
dc.contributor.authorOh, In Hwan-
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dc.contributor.authorOkekunle, Akinkunmi Paul-
dc.contributor.authorOkonji, Osaretin Christabel-
dc.contributor.authorOkwute, Patrick Godwin-
dc.contributor.authorOlagunju, Andrew T.-
dc.contributor.authorOlasupo, Omotola O.-
dc.contributor.authorOlatubi, Matthew Idowu-
dc.contributor.authorOliveira, Glaucia Maria Moraes-
dc.contributor.authorOlusanya, Bolajoko Olubukunola-
dc.contributor.authorOlusanya, Jacob Olusegun-
dc.contributor.authorOluwatunase, Gideon Olamilekan-
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dc.contributor.authorOnwujekwe, Obinna E.-
dc.contributor.authorOrdak, Michal-
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dc.contributor.authorOrtiz, Alberto-
dc.contributor.authorOrtiz-Prado, Esteban-
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dc.contributor.authorOsuagwu, Uchechukwu Levi-
dc.contributor.authorOsuolale, Olayinka-
dc.contributor.authorOtoiu, Adrian-
dc.contributor.authorOtstavnov, Stanislav S.-
dc.contributor.authorOuyahia, Amel-
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dc.contributor.authorOzten, Yaz-
dc.contributor.authorMahesh Padukudru, P. A.-
dc.contributor.authorFallahy, Mohammad Taha Pahlevan-
dc.contributor.authorPan, Feng-
dc.contributor.authorPan, Hai Feng-
dc.contributor.authorPana, Adrian-
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dc.contributor.authorPanda-Jonas, Songhomitra-
dc.contributor.authorPangaribuan, Helena Ullyartha-
dc.contributor.authorPanos, Georgios D.-
dc.contributor.authorPanos, Leonidas D.-
dc.contributor.authorPantazopoulos, Ioannis-
dc.contributor.authorStoian, Anca Mihaela Pantea-
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dc.contributor.authorParthasarathi, Ashwaghosha-
dc.contributor.authorPashaei, Ava-
dc.contributor.authorPassera, Roberto-
dc.contributor.authorPatel, Hemal M.-
dc.contributor.authorPatel, Jay-
dc.contributor.authorPatil, Shankargouda-
dc.contributor.authorPatoulias, Dimitrios-
dc.contributor.authorPatthipati, Venkata Suresh-
dc.contributor.authorPaudel, Uttam-
dc.contributor.authorPaun, Mihaela-
dc.contributor.authorToroudi, Hamidreza Pazoki-
dc.contributor.authorPease, Spencer A.-
dc.contributor.authorPeden, Amy E.-
dc.contributor.authorPedersini, Paolo-
dc.contributor.authorPeng, Minjin-
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dc.contributor.authorPepito, Veincent Christian Filipino-
dc.contributor.authorPeprah, Prince-
dc.contributor.authorPereira, Gavin-
dc.contributor.authorPeres, Mario F.P.-
dc.contributor.authorPerianayagam, Arokiasamy-
dc.contributor.authorPerico, Norberto-
dc.contributor.authorPerna, Simone-
dc.contributor.authorPestell, Richard G.-
dc.contributor.authorPetermann-Rocha, Fanny Emily-
dc.contributor.authorPham, Hoang Tran-
dc.contributor.authorPhilip, Anil K.-
dc.contributor.authorPierannunzio, Daniela-
dc.contributor.authorPigeolet, Manon-
dc.contributor.authorPigott, David M.-
dc.contributor.authorPlotnikov, Evgenii-
dc.contributor.authorPoddighe, Dimitri-
dc.contributor.authorPollner, Peter-
dc.contributor.authorPoluru, Ramesh-
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dc.contributor.authorPourali, Ghazaleh-
dc.contributor.authorPourshams, Akram-
dc.contributor.authorPourtaheri, Naeimeh-
dc.contributor.authorPrabhu, Disha-
dc.contributor.authorPrada, Sergio I.-
dc.contributor.authorPradhan, Pranil Man Singh-
dc.contributor.authorPrasad, Manya-
dc.contributor.authorPrashant, Akila-
dc.contributor.authorPurohit, Bharathi M.-
dc.contributor.authorPuvvula, Jagadeesh-
dc.contributor.authorQasim, Nameer Hashim-
dc.contributor.authorQattea, Ibrahim-
dc.contributor.authorDeepthi, R.-
dc.contributor.authorRad, Mehrdad Rabiee-
dc.contributor.authorRadfar, Amir-
dc.contributor.authorRadhakrishnan, Venkatraman-
dc.contributor.authorRaee, Pourya-
dc.contributor.authorShahraki, Hadi Raeisi-
dc.contributor.authorRafiei, Alireza-
dc.contributor.authorAlavi, Seyedeh Niloufar Rafiei-
dc.contributor.authorRaggi, Cat-
dc.contributor.authorRaghav, Pankaja Raghav-
dc.contributor.authorRahim, Fakher-
dc.contributor.authorRahim, Md Jillur-
dc.contributor.authorRahman, Md Mosfequr-
dc.contributor.authorUr Rahman, Mohammad Hifz-
dc.contributor.authorRahman, Mosiur-
dc.contributor.authorRahman, Muhammad Aziz-
dc.contributor.authorRahmanian, Vahid-
dc.contributor.authorRahmati, Masoud-
dc.contributor.authorRahnavard, Niloufar-
dc.contributor.authorRai, Pramila-
dc.contributor.authorRaimondo, Diego-
dc.contributor.authorRajabpour-Sanati, Ali-
dc.contributor.authorRajput, Prashant-
dc.contributor.authorRam, Prasanna-
dc.contributor.authorRamasamy, Shakthi Kumaran-
dc.contributor.authorRana, Juwel-
dc.contributor.authorRana, Kritika-
dc.contributor.authorRana, Shailendra Singh-
dc.contributor.authorRanabhat, Chhabi Lal-
dc.contributor.authorRancic, Nemanja-
dc.contributor.authorRane, Amey-
dc.contributor.authorRanjan, Shubham-
dc.contributor.authorRao, Chythra R.-
dc.contributor.authorRao, Indu Ramachandra-
dc.contributor.authorRapaka, Deepthi-
dc.contributor.authorRasella, Davide-
dc.contributor.authorRashedi, Sina-
dc.contributor.authorRashedi, Vahid-
dc.contributor.authorRashidi, Mohammad Mahdi-
dc.contributor.authorRasul, Azad-
dc.contributor.authorRatan, Zubair Ahmed-
dc.contributor.authorBabu, Giridhara Rathnaiah-
dc.contributor.authorRauniyar, Santosh Kumar-
dc.contributor.authorRavikumar, Nakul-
dc.contributor.authorRawaf, David Laith-
dc.contributor.authorRawaf, Salman-
dc.contributor.authorRawassizadeh, Reza-
dc.contributor.authorRawlley, Bharat-
dc.contributor.authorReddy, Murali Mohan Rama Krishna-
dc.contributor.authorRedwan, Elrashdy Moustafa Mohamed-
dc.contributor.authorRemuzzi, Giuseppe-
dc.contributor.authorReshmi, Bhageerathy-
dc.contributor.authorRezaei, Nazila-
dc.contributor.authorNejad, Aida Rezaei-
dc.contributor.authorRezaeian, Mohsen-
dc.contributor.authorRiad, Abanoub-
dc.contributor.authorRiaz, Mavra A.-
dc.contributor.authorRickard, Jennifer-
dc.contributor.authorRikhtegar, Reza-
dc.contributor.authorRobinson-Oden, Hannah Elizabeth-
dc.contributor.authorRodrigues, Celia Fortuna-
dc.contributor.authorRodriguez, Jefferson Antonio Buendia-
dc.contributor.authorRohilla, Ravi-
dc.contributor.authorRomadlon, Debby Syahru-
dc.contributor.authorRonfani, Luca-
dc.contributor.authorRout, Himanshu Sekhar-
dc.contributor.authorRoy, Bedanta-
dc.contributor.authorRoy, Nitai-
dc.contributor.authorRoy, Priyanka-
dc.contributor.authorRubagotti, Enrico-
dc.contributor.authorDe Andrade Ruela, Guilherme-
dc.contributor.authorRumisha, Susan Fred-
dc.contributor.authorRunghien, Tilleye-
dc.contributor.authorManjula, S.-
dc.contributor.authorChandan, S. N.-
dc.contributor.authorSaad, Aly M.A.-
dc.contributor.authorSaadatian, Zahra-
dc.contributor.authorSaber-Ayad, Maha Mohamed-
dc.contributor.authorSaberiKamarposhti, Morteza-
dc.contributor.authorSabour, Siamak-
dc.contributor.authorSada, Fatos-
dc.contributor.authorSaddik, Basema-
dc.contributor.authorSadee, Bashdar Abuzed-
dc.contributor.authorSadeghi, Ehsan-
dc.contributor.authorSadeghi, Erfan-
dc.contributor.authorSaeb, Mohammad Reza-
dc.contributor.authorSaeed, Umar-
dc.contributor.authorSafi, Sher Zaman-
dc.contributor.authorSagoe, Dominic-
dc.contributor.authorSaha, Manika-
dc.contributor.authorSahebkar, Amirhossein-
dc.contributor.authorSahoo, Soumya Swaroop-
dc.contributor.authorSahu, Monalisha-
dc.contributor.authorSaif, Zahra-
dc.contributor.authorSakshaug, Joseph W.-
dc.contributor.authorSalamati, Payman-
dc.contributor.authorSalami, Afeez Abolarinwa-
dc.contributor.authorSaleh, Mohamed A.-
dc.contributor.authorSalem, Marwa Rashad-
dc.contributor.authorSalem, Mohammed Z.Y.-
dc.contributor.authorSalimi, Sohrab-
dc.contributor.authorSamadzadeh, Sara-
dc.contributor.authorSamodra, Yoseph Leonardo-
dc.contributor.authorSamuel, Vijaya Paul-
dc.contributor.authorSamy, Abdallah M.-
dc.contributor.authorSanabria, Juan-
dc.contributor.authorSanadgol, Nima-
dc.contributor.authorSanna, Francesca-
dc.contributor.authorSantric-Milicevic, Milena M.-
dc.contributor.authorSaqib, Haaris-
dc.contributor.authorSaraswathy, Sivan Yegnanarayana Iyer-
dc.contributor.authorSaravanan, Aswini-
dc.contributor.authorSaravi, Babak-
dc.contributor.authorSarikhani, Yaser-
dc.contributor.authorSarkar, Tanmay-
dc.contributor.authorSarmiento-Suárez, Rodrigo-
dc.contributor.authorSarode, Gargi Sachin-
dc.contributor.authorSarode, Sachin C.-
dc.contributor.authorSarveazad, Arash-
dc.contributor.authorSathian, Brijesh-
dc.contributor.authorSathish, Thirunavukkarasu-
dc.contributor.authorSathyanarayan, Anudeep-
dc.contributor.authorSayeed, Abu-
dc.contributor.authorSayeed, Md Abu-
dc.contributor.authorScarmeas, Nikolaos-
dc.contributor.authorSchlee, Winfried-
dc.contributor.authorSchuermans, Art-
dc.contributor.authorSchwebel, David C.-
dc.contributor.authorSchwendicke, Falk-
dc.contributor.authorSelvaraj, Siddharthan-
dc.contributor.authorSengupta, Pallav-
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dc.date.accessioned2025-09-16T04:20:46Z-
dc.date.available2025-09-16T04:20:46Z-
dc.date.issued2024-
dc.identifier.citationLancet, 2024, v. 403, n. 10440, p. 2057-2099-
dc.identifier.issn0140-6736-
dc.identifier.urihttp://hdl.handle.net/10722/361793-
dc.description.abstractBackground: Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10–54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in habitable areas, and under-5 mortality) were given equal weights, and analyses were conducted utilising the MR-BRT (meta-regression—Bayesian, regularised, trimmed) tool. To capture time-series trends in CCF50 not explained by these covariates, we used a first-order autoregressive model on the residual term. CCF50 as a proportion of each 5-year ASFR was predicted using a linear mixed-effects model with fixed-effects covariates (female educational attainment and contraceptive met need) and random intercepts for geographical regions. Projected TFRs were then computed for each calendar year as the sum of single-year ASFRs across age groups. The reference forecast is our estimate of the most likely fertility future given the model, past fertility, forecasts of covariates, and historical relationships between covariates and fertility. We additionally produced forecasts for multiple alternative scenarios in each location: the UN Sustainable Development Goal (SDG) for education is achieved by 2030; the contraceptive met need SDG is achieved by 2030; pro-natal policies are enacted to create supportive environments for those who give birth; and the previous three scenarios combined. Uncertainty from past data inputs and model estimation was propagated throughout analyses by taking 1000 draws for past and present fertility estimates and 500 draws for future forecasts from the estimated distribution for each metric, with 95% uncertainty intervals (UIs) given as the 2·5 and 97·5 percentiles of the draws. To evaluate the forecasting performance of our model and others, we computed skill values—a metric assessing gain in forecasting accuracy—by comparing predicted versus observed ASFRs from the past 15 years (2007–21). A positive skill metric indicates that the model being evaluated performs better than the baseline model (here, a simplified model holding 2007 values constant in the future), and a negative metric indicates that the evaluated model performs worse than baseline. Findings: During the period from 1950 to 2021, global TFR more than halved, from 4·84 (95% UI 4·63–5·06) to 2·23 (2·09–2·38). Global annual livebirths peaked in 2016 at 142 million (95% UI 137–147), declining to 129 million (121–138) in 2021. Fertility rates declined in all countries and territories since 1950, with TFR remaining above 2·1—canonically considered replacement-level fertility—in 94 (46·1%) countries and territories in 2021. This included 44 of 46 countries in sub-Saharan Africa, which was the super-region with the largest share of livebirths in 2021 (29·2% [28·7–29·6]). 47 countries and territories in which lowest estimated fertility between 1950 and 2021 was below replacement experienced one or more subsequent years with higher fertility; only three of these locations rebounded above replacement levels. Future fertility rates were projected to continue to decline worldwide, reaching a global TFR of 1·83 (1·59–2·08) in 2050 and 1·59 (1·25–1·96) in 2100 under the reference scenario. The number of countries and territories with fertility rates remaining above replacement was forecast to be 49 (24·0%) in 2050 and only six (2·9%) in 2100, with three of these six countries included in the 2021 World Bank-defined low-income group, all located in the GBD super-region of sub-Saharan Africa. The proportion of livebirths occurring in sub-Saharan Africa was forecast to increase to more than half of the world's livebirths in 2100, to 41·3% (39·6–43·1) in 2050 and 54·3% (47·1–59·5) in 2100. The share of livebirths was projected to decline between 2021 and 2100 in most of the six other super-regions—decreasing, for example, in south Asia from 24·8% (23·7–25·8) in 2021 to 16·7% (14·3–19·1) in 2050 and 7·1% (4·4–10·1) in 2100—but was forecast to increase modestly in the north Africa and Middle East and high-income super-regions. Forecast estimates for the alternative combined scenario suggest that meeting SDG targets for education and contraceptive met need, as well as implementing pro-natal policies, would result in global TFRs of 1·65 (1·40–1·92) in 2050 and 1·62 (1·35–1·95) in 2100. The forecasting skill metric values for the IHME model were positive across all age groups, indicating that the model is better than the constant prediction. Interpretation: Fertility is declining globally, with rates in more than half of all countries and territories in 2021 below replacement level. Trends since 2000 show considerable heterogeneity in the steepness of declines, and only a small number of countries experienced even a slight fertility rebound after their lowest observed rate, with none reaching replacement level. Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. Future fertility rates will continue to decline worldwide and will remain low even under successful implementation of pro-natal policies. These changes will have far-reaching economic and societal consequences due to ageing populations and declining workforces in higher-income countries, combined with an increasing share of livebirths among the already poorest regions of the world. Funding: Bill & Melinda Gates Foundation.-
dc.languageeng-
dc.relation.ispartofLancet-
dc.titleGlobal fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0140-6736(24)00550-6-
dc.identifier.pmid38521087-
dc.identifier.scopuseid_2-s2.0-85188450830-
dc.identifier.volume403-
dc.identifier.issue10440-
dc.identifier.spage2057-
dc.identifier.epage2099-
dc.identifier.eissn1474-547X-

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