File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Dosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis

TitleDosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis
Authors
KeywordsDosimetric parameters
Nasopharyngeal carcinoma
Radiotherapy
Temporal lobe necrosis
Issue Date1-Jun-2024
PublisherElsevier
Citation
Radiotherapy & Oncology, 2024, v. 195 How to Cite?
Abstract

This systematic review examines the role of dosimetric parameters in predicting temporal lobe necrosis (TLN) risk in nasopharyngeal carcinoma (NPC) patients treated with three-dimensional conformal RT (3D-CRT), intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). TLN is a serious late complication that can adversely affect the quality of life of NPC patients. Understanding the relationship between dosimetric parameters and TLN can guide treatment planning and minimize radiation-related complications.

A comprehensive search identified relevant studies published up to July 2023. Studies reporting on dosimetric parameters and TLN in NPC patients undergoing 3D-CRT, IMRT, and VMAT were included. TLN incidence, follow-up duration, and correlation with dosimetric parameters of the temporal lobe were analyzed.

The review included 30 studies with median follow-up durations ranging from 28 to 110 months. The crude incidence of TLN varied from 2.3 % to 47.3 % and the average crude incidence of TLN is approximately 14 %. Dmax and D1cc emerged as potential predictors of TLN in 3D-CRT and IMRT-treated NPC patients. Threshold values of >72 Gy for Dmax and >62 Gy for D1cc were associated with increased TLN risk. However, other factors should also be considered, including host characteristics, tumor-specific features and therapeutic factors.

In conclusion, this systematic review highlights the significance of dosimetric parameters, particularly Dmax and D1cc, in predicting TLN risk in NPC patients undergoing 3D-CRT, IMRT, and VMAT. The findings provide valuable insights that can help in developing optimal treatment planning strategies and contribute to the development of clinical guidelines in this field.


Persistent Identifierhttp://hdl.handle.net/10722/342831
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.702

 

DC FieldValueLanguage
dc.contributor.authorDong, Jun-
dc.contributor.authorNg, Wai Tong-
dc.contributor.authorWong, Charlene HL-
dc.contributor.authorLi, Ji-Shi-
dc.contributor.authorBollen, Heleen-
dc.contributor.authorChow, James CH-
dc.contributor.authorEisbruch, Avraham-
dc.contributor.authorLee, Anne WM-
dc.contributor.authorLee, Victor HF-
dc.contributor.authorNg, Sweet Ping-
dc.contributor.authorNuyts, Sandra-
dc.contributor.authorSmee, Robert-
dc.contributor.authorFerlito, Alfio-
dc.date.accessioned2024-05-02T03:06:11Z-
dc.date.available2024-05-02T03:06:11Z-
dc.date.issued2024-06-01-
dc.identifier.citationRadiotherapy & Oncology, 2024, v. 195-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/342831-
dc.description.abstract<p>This systematic review examines the role of dosimetric parameters in predicting temporal lobe necrosis (TLN) risk in nasopharyngeal carcinoma (NPC) patients treated with three-dimensional conformal RT (3D-CRT), intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). TLN is a serious late complication that can adversely affect the quality of life of NPC patients. Understanding the relationship between dosimetric parameters and TLN can guide treatment planning and minimize radiation-related complications.</p><p>A comprehensive search identified relevant studies published up to July 2023. Studies reporting on dosimetric parameters and TLN in NPC patients undergoing 3D-CRT, IMRT, and VMAT were included. TLN incidence, follow-up duration, and correlation with dosimetric parameters of the temporal lobe were analyzed.</p><p>The review included 30 studies with median follow-up durations ranging from 28 to 110 months. The crude incidence of TLN varied from 2.3 % to 47.3 % and the average crude incidence of TLN is approximately 14 %. Dmax and D1cc emerged as potential predictors of TLN in 3D-CRT and IMRT-treated NPC patients. Threshold values of >72 Gy for Dmax and >62 Gy for D1cc were associated with increased TLN risk. However, other factors should also be considered, including host characteristics, tumor-specific features and therapeutic factors.</p><p>In conclusion, this systematic review highlights the significance of dosimetric parameters, particularly Dmax and D1cc, in predicting TLN risk in NPC patients undergoing 3D-CRT, IMRT, and VMAT. The findings provide valuable insights that can help in developing optimal treatment planning strategies and contribute to the development of clinical guidelines in this field.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofRadiotherapy & Oncology-
dc.subjectDosimetric parameters-
dc.subjectNasopharyngeal carcinoma-
dc.subjectRadiotherapy-
dc.subjectTemporal lobe necrosis-
dc.titleDosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis-
dc.typeArticle-
dc.identifier.doi10.1016/j.radonc.2024.110258-
dc.identifier.scopuseid_2-s2.0-85189497939-
dc.identifier.volume195-
dc.identifier.issnl0167-8140-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats