File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

TitleOverall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors
Keywordsberberine
blood glucose
efficacy
insulin resistance
safety
sex-specific effect
Issue Date2023
Citation
Journal of Nutrition, 2023, v. 153, n. 10, p. 2939-2950 How to Cite?
AbstractBackground: Berberine is widely available as a nutraceutical supplement for improving glucose metabolism. Berberine affects sex hormones, raising the possibility that its effects on glycemic traits and insulin sensitivity have sex disparity which has been overlooked. Objective: To assess the overall and sex-specific effects of berberine on glycemic- and insulin-related traits. Methods: We identified randomized trials of berberine versus placebo from Medline, Embase, CNKI, clinical trial registries and previous systematic reviews. Mean differences were estimated using inverse-variance weighting with random effects models. Subgroup analyses were conducted by sex, diabetes diagnosis, trial duration, berberine dose and ethnicity. Results: We identified 20 eligible studies (n = 1761). Berberine lowered fasting glucose (−0.52 mmol/L, 95% CI −0.72 to −0.33; 18 studies, n = 1522), HbA1c (−4.48 mmol/mol, 95% CI −6.53 to −2.44, 7 studies, n = 756), fasting insulin (−2.36 mU/L, 95% CI −3.64 to −1.08, 11 studies, n = 966), HOMA-IR (−0.85, 95% CI −1.16 to −0.53,12 studies, n = 1065), and 2-h postprandial glucose (−1.81 mmol/L, 95% CI −2.37 to −1.24, 4 studies, n = 501). Effects on fasting glucose and HOMA-IR showed potential differences by sex, with larger reductions in women than in men. Comparing 4 studies conducted in women to one study conducted in men, the mean difference was −0.21 mmol/L (95% CI −0.41 to −0.00) for fasting glucose and −0.97 (95% CI −1.84 to −0.10) for HOMA-IR. We also found larger reductions in fasting glucose in participants with diabetes and in Asians. Conclusion: Berberine is effective in improving glucose metabolism and may result in larger effects on fasting glucose in women, in people with diabetes and in Asians, but subgroup comparisons remain to be replicated given the limited number of studies. Berberine can be considered as a complementary intervention in individuals who may benefit from modest improvements in glucose metabolism and who prefer taking a nutraceutical. Study registration: PROSPERO (CRD42022345172).
Persistent Identifierhttp://hdl.handle.net/10722/341417
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.098
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Jie V.-
dc.contributor.authorHuang, Xin-
dc.contributor.authorZhang, Junmeng-
dc.contributor.authorChan, Yap Hang-
dc.contributor.authorTse, Hung Fat-
dc.contributor.authorBlais, Joseph E.-
dc.date.accessioned2024-03-13T08:42:39Z-
dc.date.available2024-03-13T08:42:39Z-
dc.date.issued2023-
dc.identifier.citationJournal of Nutrition, 2023, v. 153, n. 10, p. 2939-2950-
dc.identifier.issn0022-3166-
dc.identifier.urihttp://hdl.handle.net/10722/341417-
dc.description.abstractBackground: Berberine is widely available as a nutraceutical supplement for improving glucose metabolism. Berberine affects sex hormones, raising the possibility that its effects on glycemic traits and insulin sensitivity have sex disparity which has been overlooked. Objective: To assess the overall and sex-specific effects of berberine on glycemic- and insulin-related traits. Methods: We identified randomized trials of berberine versus placebo from Medline, Embase, CNKI, clinical trial registries and previous systematic reviews. Mean differences were estimated using inverse-variance weighting with random effects models. Subgroup analyses were conducted by sex, diabetes diagnosis, trial duration, berberine dose and ethnicity. Results: We identified 20 eligible studies (n = 1761). Berberine lowered fasting glucose (−0.52 mmol/L, 95% CI −0.72 to −0.33; 18 studies, n = 1522), HbA1c (−4.48 mmol/mol, 95% CI −6.53 to −2.44, 7 studies, n = 756), fasting insulin (−2.36 mU/L, 95% CI −3.64 to −1.08, 11 studies, n = 966), HOMA-IR (−0.85, 95% CI −1.16 to −0.53,12 studies, n = 1065), and 2-h postprandial glucose (−1.81 mmol/L, 95% CI −2.37 to −1.24, 4 studies, n = 501). Effects on fasting glucose and HOMA-IR showed potential differences by sex, with larger reductions in women than in men. Comparing 4 studies conducted in women to one study conducted in men, the mean difference was −0.21 mmol/L (95% CI −0.41 to −0.00) for fasting glucose and −0.97 (95% CI −1.84 to −0.10) for HOMA-IR. We also found larger reductions in fasting glucose in participants with diabetes and in Asians. Conclusion: Berberine is effective in improving glucose metabolism and may result in larger effects on fasting glucose in women, in people with diabetes and in Asians, but subgroup comparisons remain to be replicated given the limited number of studies. Berberine can be considered as a complementary intervention in individuals who may benefit from modest improvements in glucose metabolism and who prefer taking a nutraceutical. Study registration: PROSPERO (CRD42022345172).-
dc.languageeng-
dc.relation.ispartofJournal of Nutrition-
dc.subjectberberine-
dc.subjectblood glucose-
dc.subjectefficacy-
dc.subjectinsulin resistance-
dc.subjectsafety-
dc.subjectsex-specific effect-
dc.titleOverall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tjnut.2023.08.016-
dc.identifier.pmid37598753-
dc.identifier.scopuseid_2-s2.0-85171299033-
dc.identifier.volume153-
dc.identifier.issue10-
dc.identifier.spage2939-
dc.identifier.epage2950-
dc.identifier.eissn1541-6100-
dc.identifier.isiWOS:001100051700001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats