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Article: Low-dose aspirin does not lower the risk of colorectal cancer in patients with type 2 diabetes taking metformin

TitleLow-dose aspirin does not lower the risk of colorectal cancer in patients with type 2 diabetes taking metformin
Authors
Keywordsaspirin
cohort study
colorectal cancer
metformin
type 2 diabetes mellitus
Issue Date2023
Citation
Journal of Internal Medicine, 2023, v. 293, n. 3, p. 371-383 How to Cite?
AbstractBackground: Low-dose aspirin and metformin have been individually associated with a reduced risk of cancer. Whether their concurrent use in adults with type 2 diabetes mellitus (T2DM) is associated with a reduced risk of colorectal cancer (CRC) is unclear. Objective: Among individuals with T2DM taking metformin, we sought to evaluate the association between low-dose aspirin versus no aspirin and the risk of CRC. Methods: A multiple-database new-user cohort study of patients with T2DM taking metformin was conducted between 2007 and 2010 (Clinical Data Analysis and Reporting System [CDARS], Hong Kong) and 2007–2016 (The Health Improvement Network [THIN], UK). The primary outcome was incident CRC. Patients were followed from index date of prescription until the earliest occurrence of an outcome of interest, an incident diagnosis of any cancer, death, or until 31 December 2019. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI). Estimates were pooled using an inverse variance random effects model, and heterogeneity was assessed using I2. Results: After one-to-one propensity-score matching, 57,534 patients were included (CDARS = 16,276; THIN = 41,258). The median (IQR) follow-up was 9.3 (6.5–10.7) years in CDARS and 3.2 (1.1–5.8) years in THIN. The concurrent use of low-dose aspirin and metformin was not associated with a lower risk of CRC compared to metformin only (HR = 0.89, 95% CI 0.75–1.05, I2 = 0%). Conclusion: Low-dose aspirin was not associated with a lower risk of CRC in patients with T2DM taking metformin. Our study does not support the routine use of low-dose aspirin in this population.
Persistent Identifierhttp://hdl.handle.net/10722/341386
ISSN
2023 Impact Factor: 9.0
2023 SCImago Journal Rankings: 2.895
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShami, Jessica J.P.-
dc.contributor.authorYan, Vincent K.C.-
dc.contributor.authorWei, Yue-
dc.contributor.authorAlwafi, Hassan-
dc.contributor.authorBlais, Joseph E.-
dc.contributor.authorWan, Eric-
dc.contributor.authorWong, Carlos K.H.-
dc.contributor.authorCheung, Ka Shing-
dc.contributor.authorLeung, Wai K.-
dc.contributor.authorWong, Martin C.S.-
dc.contributor.authorWong, Ian C.K.-
dc.contributor.authorChan, Esther W.-
dc.date.accessioned2024-03-13T08:42:25Z-
dc.date.available2024-03-13T08:42:25Z-
dc.date.issued2023-
dc.identifier.citationJournal of Internal Medicine, 2023, v. 293, n. 3, p. 371-383-
dc.identifier.issn0954-6820-
dc.identifier.urihttp://hdl.handle.net/10722/341386-
dc.description.abstractBackground: Low-dose aspirin and metformin have been individually associated with a reduced risk of cancer. Whether their concurrent use in adults with type 2 diabetes mellitus (T2DM) is associated with a reduced risk of colorectal cancer (CRC) is unclear. Objective: Among individuals with T2DM taking metformin, we sought to evaluate the association between low-dose aspirin versus no aspirin and the risk of CRC. Methods: A multiple-database new-user cohort study of patients with T2DM taking metformin was conducted between 2007 and 2010 (Clinical Data Analysis and Reporting System [CDARS], Hong Kong) and 2007–2016 (The Health Improvement Network [THIN], UK). The primary outcome was incident CRC. Patients were followed from index date of prescription until the earliest occurrence of an outcome of interest, an incident diagnosis of any cancer, death, or until 31 December 2019. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI). Estimates were pooled using an inverse variance random effects model, and heterogeneity was assessed using I2. Results: After one-to-one propensity-score matching, 57,534 patients were included (CDARS = 16,276; THIN = 41,258). The median (IQR) follow-up was 9.3 (6.5–10.7) years in CDARS and 3.2 (1.1–5.8) years in THIN. The concurrent use of low-dose aspirin and metformin was not associated with a lower risk of CRC compared to metformin only (HR = 0.89, 95% CI 0.75–1.05, I2 = 0%). Conclusion: Low-dose aspirin was not associated with a lower risk of CRC in patients with T2DM taking metformin. Our study does not support the routine use of low-dose aspirin in this population.-
dc.languageeng-
dc.relation.ispartofJournal of Internal Medicine-
dc.subjectaspirin-
dc.subjectcohort study-
dc.subjectcolorectal cancer-
dc.subjectmetformin-
dc.subjecttype 2 diabetes mellitus-
dc.titleLow-dose aspirin does not lower the risk of colorectal cancer in patients with type 2 diabetes taking metformin-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/joim.13590-
dc.identifier.pmid36382924-
dc.identifier.scopuseid_2-s2.0-85144142878-
dc.identifier.volume293-
dc.identifier.issue3-
dc.identifier.spage371-
dc.identifier.epage383-
dc.identifier.eissn1365-2796-
dc.identifier.isiWOS:000897873300001-

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