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Article: Hospitalized acute exacerbation in chronic obstructive pulmonary disease – impact on long-term renal outcomes
Title | Hospitalized acute exacerbation in chronic obstructive pulmonary disease – impact on long-term renal outcomes |
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Authors | |
Keywords | Acute exacerbation Acute kidney injury Chronic Kidney Disease Chronic Obstructive Pulmonary Disease |
Issue Date | 18-Jan-2024 |
Publisher | BioMed Central |
Citation | Respiratory Research, 2024, v. 25, n. 1 How to Cite? |
Abstract | IntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common and preventable event in patients with chronic obstructive pulmonary disease (COPD). Data regarding the impact of AECOPD on short- and long-term renal outcomes are lacking. MethodsWe included all COPD patients who were followed at Queen Mary Hospital (QMH) in year 2015 and reviewed their clinical/renal outcomes in subsequent five years. Relationships between AECOPD and adverse renal outcomes were evaluated. Results371 COPD patients were included. 169 patients had hospitalized AECOPD in past one year (HAE group) while 202 patients did not (non-HAE group). 285 patients (76.8%) had renal progression/death and 102 (27.5%) patients developed acute kidney injury (AKI). HAE group showed a more rapid eGFR decline than non-HAE group (-4.64 mL/min/1.73m2/year vs. -2.40 mL/min/1.73m2/year, p = 0.025). HAE group had significantly higher risk for renal progression/death at 5 years [adjusted OR (aOR) 2.380 (95% CI = 1.144–4.954), p = 0.020]. The frequency of hospitalized AECOPD in past 3 years, any AECOPD in past 3 years, hospitalized AECOPD in past 3 years were also predictive of renal progression/death at 5 years [aOR were 1.176 (95% CI = 1.038– 1.331), 2.998 (95% CI = 1.438–6.250) and 2.887 (95% CI = 1.409–5.917) respectively; p = 0.011, 0.003 and 0.004]. HAE group also showed significantly higher risk of AKI [adjusted HR (aHR) 2.430; 95% CI = 1.306–4.519, p = 0.005]. ConclusionsAECOPD, in particular HAE, was associated with increased risk of renal progression/death and AKI. Prevention of AECOPD, especially HAE, may potentially improve short- and long-term renal outcomes in COPD patients. |
Persistent Identifier | http://hdl.handle.net/10722/340747 |
ISSN | 2010 Impact Factor: 2.859 2020 SCImago Journal Rankings: 1.846 |
DC Field | Value | Language |
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dc.contributor.author | Kwok, Wang Chun | - |
dc.contributor.author | Tam, Terence CC | - |
dc.contributor.author | Ho, James CM | - |
dc.contributor.author | Lam, David CL | - |
dc.contributor.author | Ip, Mary SM | - |
dc.contributor.author | Yap, Desmond YH | - |
dc.date.accessioned | 2024-03-11T10:46:49Z | - |
dc.date.available | 2024-03-11T10:46:49Z | - |
dc.date.issued | 2024-01-18 | - |
dc.identifier.citation | Respiratory Research, 2024, v. 25, n. 1 | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340747 | - |
dc.description.abstract | <h3>Introduction</h3><p>Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common and preventable event in patients with chronic obstructive pulmonary disease (COPD). Data regarding the impact of AECOPD on short- and long-term renal outcomes are lacking.</p><h3>Methods</h3><p>We included all COPD patients who were followed at Queen Mary Hospital (QMH) in year 2015 and reviewed their clinical/renal outcomes in subsequent five years. Relationships between AECOPD and adverse renal outcomes were evaluated.</p><h3>Results</h3><p>371 COPD patients were included. 169 patients had hospitalized AECOPD in past one year (HAE group) while 202 patients did not (non-HAE group). 285 patients (76.8%) had renal progression/death and 102 (27.5%) patients developed acute kidney injury (AKI). HAE group showed a more rapid eGFR decline than non-HAE group (-4.64 mL/min/1.73m<sup>2</sup>/year vs. -2.40 mL/min/1.73m<sup>2</sup>/year, <em>p</em> = 0.025). HAE group had significantly higher risk for renal progression/death at 5 years [adjusted OR (aOR) 2.380 (95% CI = 1.144–4.954), <em>p</em> = 0.020]. The frequency of hospitalized AECOPD in past 3 years, any AECOPD in past 3 years, hospitalized AECOPD in past 3 years were also predictive of renal progression/death at 5 years [aOR were 1.176 (95% CI = 1.038– 1.331), 2.998 (95% CI = 1.438–6.250) and 2.887 (95% CI = 1.409–5.917) respectively; <em>p</em> = 0.011, 0.003 and 0.004]. HAE group also showed significantly higher risk of AKI [adjusted HR (aHR) 2.430; 95% CI = 1.306–4.519, <em>p</em> = 0.005].</p><h3>Conclusions</h3><p>AECOPD, in particular HAE, was associated with increased risk of renal progression/death and AKI. Prevention of AECOPD, especially HAE, may potentially improve short- and long-term renal outcomes in COPD patients.</p> | - |
dc.language | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.ispartof | Respiratory Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Acute exacerbation | - |
dc.subject | Acute kidney injury | - |
dc.subject | Chronic Kidney Disease | - |
dc.subject | Chronic Obstructive Pulmonary Disease | - |
dc.title | Hospitalized acute exacerbation in chronic obstructive pulmonary disease – impact on long-term renal outcomes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12931-023-02635-8 | - |
dc.identifier.scopus | eid_2-s2.0-85182644121 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 1 | - |
dc.identifier.eissn | 1465-993X | - |
dc.identifier.issnl | 1465-9921 | - |