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Article: Age-matched versus non-age-matched comparison of clinical and functional differences between delusional disorder and schizophrenia: a systematic review

TitleAge-matched versus non-age-matched comparison of clinical and functional differences between delusional disorder and schizophrenia: a systematic review
Authors
Keywordscognition
functioning
outcomes
psychopathology
psychotic disorders
symptoms
systematic review
Issue Date10-Oct-2023
PublisherFrontiers Media
Citation
Frontiers in Psychiatry, 2023, v. 14 How to Cite?
AbstractBackground: It has been widely suggested that delusional disorder (DD) differs from schizophrenia (SZ). However, whether the two disorders are truly distinct from each other is inconclusive as an older age of onset is closely linked to a better prognosis in psychotic disorders. In order to delineate the potential influence of age on outcomes, we undertook a systematic review on the clinical and functional differences between DD and SZ in age-matched and non-age-matched cohorts. Methods: Electronic databases were retrieved up to May 2022. Included studies were analyzed with reference to statements about clinical, cognitive and functional differences between DD and SZ. Results: Data synthesized from 8 studies showed (1) extensive effects of age on positive, general psychopathological symptoms and functioning, but (2) consistent differences between the two disorders in terms of negative symptoms and hospitalizations regardless of age matching. Conclusion: There is currently insufficient evidence to conclude whether DD is completely distinct from SZ, but our review showed support for the confounding effect of age in comparisons of psychotic disorders with different ages of onset. Future studies shall take note of other possible confounding variables, methods of age-matching and the importance of longitudinal information in deducing whether the two disorders differ from each other in course and outcome.
Persistent Identifierhttp://hdl.handle.net/10722/340139
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.155
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, CLM-
dc.contributor.authorChiu, TC-
dc.contributor.authorChan, EWT-
dc.contributor.authorHui, PWM-
dc.contributor.authorTao, TJ-
dc.contributor.authorSuen, YN-
dc.contributor.authorChan, SKW-
dc.contributor.authorChang, WC-
dc.contributor.authorLee, EHM-
dc.contributor.authorChen, EYH-
dc.date.accessioned2024-03-11T10:41:57Z-
dc.date.available2024-03-11T10:41:57Z-
dc.date.issued2023-10-10-
dc.identifier.citationFrontiers in Psychiatry, 2023, v. 14-
dc.identifier.issn1664-0640-
dc.identifier.urihttp://hdl.handle.net/10722/340139-
dc.description.abstractBackground: It has been widely suggested that delusional disorder (DD) differs from schizophrenia (SZ). However, whether the two disorders are truly distinct from each other is inconclusive as an older age of onset is closely linked to a better prognosis in psychotic disorders. In order to delineate the potential influence of age on outcomes, we undertook a systematic review on the clinical and functional differences between DD and SZ in age-matched and non-age-matched cohorts. Methods: Electronic databases were retrieved up to May 2022. Included studies were analyzed with reference to statements about clinical, cognitive and functional differences between DD and SZ. Results: Data synthesized from 8 studies showed (1) extensive effects of age on positive, general psychopathological symptoms and functioning, but (2) consistent differences between the two disorders in terms of negative symptoms and hospitalizations regardless of age matching. Conclusion: There is currently insufficient evidence to conclude whether DD is completely distinct from SZ, but our review showed support for the confounding effect of age in comparisons of psychotic disorders with different ages of onset. Future studies shall take note of other possible confounding variables, methods of age-matching and the importance of longitudinal information in deducing whether the two disorders differ from each other in course and outcome.-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Psychiatry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcognition-
dc.subjectfunctioning-
dc.subjectoutcomes-
dc.subjectpsychopathology-
dc.subjectpsychotic disorders-
dc.subjectsymptoms-
dc.subjectsystematic review-
dc.titleAge-matched versus non-age-matched comparison of clinical and functional differences between delusional disorder and schizophrenia: a systematic review-
dc.typeArticle-
dc.identifier.doi10.3389/fpsyt.2023.1272833-
dc.identifier.scopuseid_2-s2.0-85174976029-
dc.identifier.volume14-
dc.identifier.eissn1664-0640-
dc.identifier.isiWOS:001090116900001-
dc.identifier.issnl1664-0640-

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