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Article: Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting

TitleAdvanced strategies in the application of gelatin-based bioink for extrusion bioprinting
Authors
KeywordsExtrusion bioprinting
Gelatin-based bioink
Tissue-like construct
Issue Date7-Jul-2023
PublisherSpringer Nature
Citation
Bio-Design and Manufacturing, 2023, v. 6, n. 5, p. 586-608 How to Cite?
Abstract

The significance of bioink suitability for the extrusion bioprinting of tissue-like constructs cannot be overemphasized. Gelatin, derived from the hydrolysis of collagen, not only can mimic the extracellular matrix to immensely support cell function, but also is suitable for extrusion under certain conditions. Thus, gelatin has been recognized as a promising bioink for extrusion bioprinting. However, the development of a gelatin-based bioink with satisfactory printability and bioactivity to fabricate complex tissue-like constructs with the desired physicochemical properties and biofunctions for a specific biomedical application is still in its infancy. Therefore, in this review, we aim to comprehensively summarize the state-of-the-art methods of gelatin-based bioink application for extrusion bioprinting. We firstly outline the properties and requirements of gelatin-based bioinks for extrusion bioprinting, highlighting the strategies to overcome their main limitations in terms of printability, structural stability and cell viability. Then, the challenges and prospects are further discussed regarding the development of ideal gelatin-based bioinks for extrusion bioprinting to create complex tissue-like constructs with preferable physicochemical properties and biofunctions.


Persistent Identifierhttp://hdl.handle.net/10722/339544
ISSN
2023 Impact Factor: 8.1
2023 SCImago Journal Rankings: 1.330
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, JR-
dc.contributor.authorHe, HM-
dc.contributor.authorLi, D-
dc.contributor.authorZhang, Q-
dc.contributor.authorXu, LZ-
dc.contributor.authorRuan, CS-
dc.date.accessioned2024-03-11T10:37:30Z-
dc.date.available2024-03-11T10:37:30Z-
dc.date.issued2023-07-07-
dc.identifier.citationBio-Design and Manufacturing, 2023, v. 6, n. 5, p. 586-608-
dc.identifier.issn2096-5524-
dc.identifier.urihttp://hdl.handle.net/10722/339544-
dc.description.abstract<p>The significance of bioink suitability for the extrusion bioprinting of tissue-like constructs cannot be overemphasized. Gelatin, derived from the hydrolysis of collagen, not only can mimic the extracellular matrix to immensely support cell function, but also is suitable for extrusion under certain conditions. Thus, gelatin has been recognized as a promising bioink for extrusion bioprinting. However, the development of a gelatin-based bioink with satisfactory printability and bioactivity to fabricate complex tissue-like constructs with the desired physicochemical properties and biofunctions for a specific biomedical application is still in its infancy. Therefore, in this review, we aim to comprehensively summarize the state-of-the-art methods of gelatin-based bioink application for extrusion bioprinting. We firstly outline the properties and requirements of gelatin-based bioinks for extrusion bioprinting, highlighting the strategies to overcome their main limitations in terms of printability, structural stability and cell viability. Then, the challenges and prospects are further discussed regarding the development of ideal gelatin-based bioinks for extrusion bioprinting to create complex tissue-like constructs with preferable physicochemical properties and biofunctions.</p>-
dc.languageeng-
dc.publisherSpringer Nature-
dc.relation.ispartofBio-Design and Manufacturing-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectExtrusion bioprinting-
dc.subjectGelatin-based bioink-
dc.subjectTissue-like construct-
dc.titleAdvanced strategies in the application of gelatin-based bioink for extrusion bioprinting-
dc.typeArticle-
dc.identifier.doi10.1007/s42242-023-00236-4-
dc.identifier.scopuseid_2-s2.0-85164104515-
dc.identifier.volume6-
dc.identifier.issue5-
dc.identifier.spage586-
dc.identifier.epage608-
dc.identifier.eissn2522-8552-
dc.identifier.isiWOS:001022650300001-
dc.publisher.placeHEIDELBERG-
dc.identifier.issnl2096-5524-

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