File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Optimal time for early therapeutic response prediction in nasopharyngeal carcinoma with functional {MRI}

TitleOptimal time for early therapeutic response prediction in nasopharyngeal carcinoma with functional {MRI}
Authors
KeywordsADC
DCE-MRI
DW-MRI
MRS
Nasopharyngeal Carcinoma
Issue Date21-Jun-2023
PublisherElsevier
Citation
Physics and Imaging in Radiation Oncology, 2023, v. 27 How to Cite?
Abstract

Background and Purpose

Physiological changes in tumour occur much earlier than morphological changes. They can potentially be used as biomarkers for therapeutic response prediction. This study aimed to investigate the optimal time for early therapeutic response prediction with multi-parametric magnetic resonance imaging (MRI) in patients with nasopharyngeal carcinoma (NPC) receiving concurrent chemo-radiotherapy (CCRT).

Material and Methods

Twenty-seven NPC patients were divided into the responder (N = 23) and the poor-responder (N = 4) groups by their primary tumour post-treatment shrinkages. Single-voxel proton MR spectroscopy (1H-MRS), diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI were scanned at baseline, weekly during CCRT and post-CCRT. The median choline peak in 1H-MRS, the median apparent diffusion coefficient (ADC) in DW-MRI, the median influx rate constant (Ktrans), reflux rate constant (Kep), volume of extravascular-extracellular space per unit volume (Ve), and initial area under the time-intensity curve for the first 60 s (iAUC60) in DCE-MRI were compared between the two groups with the Mann-Whitney tests for any significant difference at different time points.

Results

In DW-MRI, the percentage increase in ADC from baseline to week-1 for the responders (median = 11.39%, IQR = 18.13%) was higher than the poor-responders (median = 4.91%, IQR = 7.86%) (p = 0.027). In DCE-MRI, the iAUC60 on week-2 was found significantly higher in the poor-responders (median = 0.398, IQR = 0.051) than the responders (median = 0.192, IQR = 0.111) (p = 0.012). No significant difference was found in median choline peaks in 1H-MRS at all time points.

Conclusion

Early perfusion and diffusion changes occurred in primary tumours of NPC patients treated with CCRT. The DW-MRI on week-1 and the DCE-MRI on week-2 were the optimal time points for early therapeutic response prediction.


Persistent Identifierhttp://hdl.handle.net/10722/337958
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMui, AW-
dc.contributor.authorLee AW-
dc.contributor.authorNg, W-
dc.contributor.authorLee, VH-
dc.contributor.authorVardhanabhuti, V-
dc.contributor.authorMan, S-
dc.contributor.authorChua, DT-
dc.contributor.authorGuan, X-
dc.date.accessioned2024-03-11T10:25:12Z-
dc.date.available2024-03-11T10:25:12Z-
dc.date.issued2023-06-21-
dc.identifier.citationPhysics and Imaging in Radiation Oncology, 2023, v. 27-
dc.identifier.urihttp://hdl.handle.net/10722/337958-
dc.description.abstract<h3>Background and Purpose</h3><p>Physiological changes in tumour occur much earlier than morphological changes. They can potentially be used as biomarkers for therapeutic response prediction. This study aimed to investigate the optimal time for early therapeutic response prediction with multi-parametric magnetic resonance imaging (MRI) in patients with nasopharyngeal carcinoma (NPC) receiving concurrent chemo-radiotherapy (CCRT).</p><h3>Material and Methods</h3><p>Twenty-seven NPC patients were divided into the responder (N = 23) and the poor-responder (N = 4) groups by their primary tumour post-treatment shrinkages. Single-voxel proton MR spectroscopy (<sup>1</sup>H-MRS), diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI were scanned at baseline, weekly during CCRT and post-CCRT. The median choline peak in <sup>1</sup>H-MRS, the median apparent diffusion coefficient (ADC) in DW-MRI, the median influx rate constant (K<sup>trans</sup>), reflux rate constant (K<sub>ep</sub>), volume of extravascular-extracellular space per unit volume (V<sub>e</sub>), and initial area under the time-intensity curve for the first 60 s (iAUC60) in DCE-MRI were compared between the two groups with the Mann-Whitney tests for any significant difference at different time points.</p><h3>Results</h3><p>In DW-MRI, the percentage increase in ADC from baseline to week-1 for the responders (median = 11.39%, IQR = 18.13%) was higher than the poor-responders (median = 4.91%, IQR = 7.86%) (p = 0.027). In DCE-MRI, the iAUC60 on week-2 was found significantly higher in the poor-responders (median = 0.398, IQR = 0.051) than the responders (median = 0.192, IQR = 0.111) (p = 0.012). No significant difference was found in median choline peaks in <sup>1</sup>H-MRS at all time points.</p><h3>Conclusion</h3><p>Early perfusion and diffusion changes occurred in primary tumours of NPC patients treated with CCRT. The DW-MRI on week-1 and the DCE-MRI on week-2 were the optimal time points for early therapeutic response prediction.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofPhysics and Imaging in Radiation Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectADC-
dc.subjectDCE-MRI-
dc.subjectDW-MRI-
dc.subjectMRS-
dc.subjectNasopharyngeal Carcinoma-
dc.titleOptimal time for early therapeutic response prediction in nasopharyngeal carcinoma with functional {MRI}-
dc.typeArticle-
dc.identifier.doi10.1016/j.phro.2023.100458-
dc.identifier.scopuseid_2-s2.0-85164008931-
dc.identifier.volume27-
dc.identifier.eissn2405-6316-
dc.identifier.isiWOS:001054794000001-
dc.identifier.issnl2405-6316-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats