File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Generation and Characterization of an influenza viral vector vaccine system for recurring and emerging respiratory viral infections
| Title | Generation and Characterization of an influenza viral vector vaccine system for recurring and emerging respiratory viral infections |
|---|---|
| Authors | |
| Issue Date | 8-Sep-2023 |
| Abstract | Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with a deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain (RBD) of the SARS-CoV-2 spike protein. The DelNS1-RBD LAIV system has been evaluated in animal models and in humans for the control of SARS-CoV-2 infections. The molecular basis of immunogenicity of DelNS1 LAIV is studied. We showed that the DelNS1 LAIV is an unique vaccine system for creating dual function vaccines against both influenza and other respiratory viruses in annual vaccination strategies. |
| Persistent Identifier | http://hdl.handle.net/10722/337831 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chen, Honglin | - |
| dc.date.accessioned | 2024-03-11T10:24:13Z | - |
| dc.date.available | 2024-03-11T10:24:13Z | - |
| dc.date.issued | 2023-09-08 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/337831 | - |
| dc.description.abstract | <p>Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with a deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain (RBD) of the SARS-CoV-2 spike protein. The DelNS1-RBD LAIV system has been evaluated in animal models and in humans for the control of SARS-CoV-2 infections. The molecular basis of immunogenicity of DelNS1 LAIV is studied. We showed that the DelNS1 LAIV is an unique vaccine system for creating dual function vaccines against both influenza and other respiratory viruses in annual vaccination strategies.<br></p> | - |
| dc.language | eng | - |
| dc.relation.ispartof | Joint TBRS & CVVT Symposium on Emerging Infectious Diseases (08/09/2023-08/09/2023, Hong Kong) | - |
| dc.title | Generation and Characterization of an influenza viral vector vaccine system for recurring and emerging respiratory viral infections | - |
| dc.type | Conference_Paper | - |