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Article: Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea

TitleGenomic and metabolic analyses reveal antagonistic lanthipeptides in archaea
Authors
Issue Date14-Apr-2023
PublisherBioMed Central
Citation
Microbiome, 2023, v. 11, n. 1 How to Cite?
Abstract

Background

Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya.

Results

Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the halophilic niche. To our best knowledge, archalan α represents the first lantibiotic and the first anti-archaeal SM from the archaea domain.

Conclusions

Our study investigates the biosynthetic potential of lanthipeptides in archaea, linking lanthipeptides to antagonistic interaction via genomic and metabolic analyses and bioassay. The discovery of these archaeal lanthipeptides is expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs.


Persistent Identifierhttp://hdl.handle.net/10722/331311
ISSN
2023 Impact Factor: 13.8
2023 SCImago Journal Rankings: 3.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, HY-
dc.contributor.authorSong, ZM-
dc.contributor.authorZhong, Z-
dc.contributor.authorZhang, DW-
dc.contributor.authorYang, W-
dc.contributor.authorZhou, L-
dc.contributor.authorOlder, EA-
dc.contributor.authorLi, J-
dc.contributor.authorWang, H-
dc.contributor.authorZeng, ZR-
dc.contributor.authorLi, YX-
dc.date.accessioned2023-09-21T06:54:36Z-
dc.date.available2023-09-21T06:54:36Z-
dc.date.issued2023-04-14-
dc.identifier.citationMicrobiome, 2023, v. 11, n. 1-
dc.identifier.issn2049-2618-
dc.identifier.urihttp://hdl.handle.net/10722/331311-
dc.description.abstract<h3>Background</h3><p>Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya.</p><h3>Results</h3><p>Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the halophilic niche. To our best knowledge, archalan α represents the first lantibiotic and the first anti-archaeal SM from the archaea domain.</p><h3>Conclusions</h3><p>Our study investigates the biosynthetic potential of lanthipeptides in archaea, linking lanthipeptides to antagonistic interaction via genomic and metabolic analyses and bioassay. The discovery of these archaeal lanthipeptides is expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs.</p>-
dc.languageeng-
dc.publisherBioMed Central-
dc.relation.ispartofMicrobiome-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleGenomic and metabolic analyses reveal antagonistic lanthipeptides in archaea-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s40168-023-01521-1-
dc.identifier.scopuseid_2-s2.0-85152544246-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.eissn2049-2618-
dc.identifier.isiWOS:000972332000001-
dc.identifier.issnl2049-2618-

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