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Article: Risk of hospitalised bronchiectasis exacerbation based on blood eosinophil counts

TitleRisk of hospitalised bronchiectasis exacerbation based on blood eosinophil counts
Authors
Keywordsbronchiectasis
eosinophil
exacerbation
phenotype
Issue Date1-Jan-2023
PublisherInternational Union Against Tuberculosis and Lung Disease
Citation
International Journal of Tuberculosis and Lung Disease, 2023, v. 27, n. 1, p. 61-65 How to Cite?
Abstract

SETTING: There has been growing recognition on the importance of phenotyping of airway diseases. The eosinophilic phenotype was proposed in bronchiectasis; however, there has not been any evidence on its association with the risk of hospitalised bronchiectasis exacerbations.

OBJECTIVE: To investigate the association between baseline blood eosinophil count (BEC) and bronchiectasis exacerbations requiring hospitalisation with validation by an independent cohort.

DESIGN: This was a retrospective cohort study.

RESULTS: Over a 24-month period, 37/318 (11.6%) study participants experienced an exacerbation requiring hospitalisation. The mean baseline serum eosinophil was 135 ± 92 cells/µL in those who had exacerbations, and 188 ± 161 cells/µL in those who did not. A serum eosinophil level of 250 cells/µL at stable state was the most significant cut-off for predicting hospitalised bronchiectasis exacerbation, which was validated by the independent cohort.

CONCLUSIONS: Patients with BEC below 250 cells/µL at stable state are at increased risk of having hospitalised bronchiectasis exacerbations.


Persistent Identifierhttp://hdl.handle.net/10722/329010
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 0.952
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, WC-
dc.contributor.authorHo, JCM-
dc.contributor.authorMa, TF-
dc.contributor.authorLam, DCL-
dc.contributor.authorChan, JWM-
dc.contributor.authorIp, M-
dc.contributor.authorTam, TCC-
dc.date.accessioned2023-08-05T07:54:36Z-
dc.date.available2023-08-05T07:54:36Z-
dc.date.issued2023-01-01-
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease, 2023, v. 27, n. 1, p. 61-65-
dc.identifier.issn1027-3719-
dc.identifier.urihttp://hdl.handle.net/10722/329010-
dc.description.abstract<p><strong>SETTING:</strong> There has been growing recognition on the importance of phenotyping of airway diseases. The eosinophilic phenotype was proposed in bronchiectasis; however, there has not been any evidence on its association with the risk of hospitalised bronchiectasis exacerbations.<br><br><strong>OBJECTIVE:</strong> To investigate the association between baseline blood eosinophil count (BEC) and bronchiectasis exacerbations requiring hospitalisation with validation by an independent cohort.<br><br><strong>DESIGN:</strong> This was a retrospective cohort study.<br><br><strong>RESULTS:</strong> Over a 24-month period, 37/318 (11.6%) study participants experienced an exacerbation requiring hospitalisation. The mean baseline serum eosinophil was 135 ± 92 cells/µL in those who had exacerbations, and 188 ± 161 cells/µL in those who did not. A serum eosinophil level of 250 cells/µL at stable state was the most significant cut-off for predicting hospitalised bronchiectasis exacerbation, which was validated by the independent cohort.<br><br><strong>CONCLUSIONS:</strong> Patients with BEC below 250 cells/µL at stable state are at increased risk of having hospitalised bronchiectasis exacerbations.<br></p>-
dc.languageeng-
dc.publisherInternational Union Against Tuberculosis and Lung Disease-
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbronchiectasis-
dc.subjecteosinophil-
dc.subjectexacerbation-
dc.subjectphenotype-
dc.titleRisk of hospitalised bronchiectasis exacerbation based on blood eosinophil counts-
dc.typeArticle-
dc.identifier.doi10.5588/ijtld.22.0489-
dc.identifier.scopuseid_2-s2.0-85149154588-
dc.identifier.volume27-
dc.identifier.issue1-
dc.identifier.spage61-
dc.identifier.epage65-
dc.identifier.eissn1815-7920-
dc.identifier.isiWOS:000992517700012-
dc.identifier.issnl1027-3719-

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