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Article: Patient-Reported Outcomes After Tetralogy of Fallot Repair
Title | Patient-Reported Outcomes After Tetralogy of Fallot Repair |
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Authors | Kovacs, Adrienne HLebovic, GeraldRaptis, StavroulaBlais, SamuelCaldarone, Christopher ADahdah, NagibDallaire, FrédéricDrolet, ChristianGrewal, JasmineHancock, Friesen Camille LHickey, EdwardKarur, Gauri RaniKhairy, PaulLeonardi, BenedettaKeir, MichelleMcCrindle, Brian WNadeem, Syed NajafNg, Ming-YenShah, Ashish HTham, Edythe BTherrien, JudithWarren, Andrew EVonder, Muhll Isabelle FVan de Bruaene, AlexanderYamamura, KenichiroFarkouh, Michael EWald, Rachel M |
Issue Date | 10-May-2023 |
Publisher | Elsevier |
Citation | Journal of the American College of Cardiology, 2023, v. 81, n. 19, p. 1937-1950 How to Cite? |
Abstract | BackgroundComprehensive assessment of tetralogy of Fallot (TOF) outcomes extends beyond morbidity and mortality to incorporate patient-reported outcomes (PROs), including quality of life (QOL) and health status (HS). ObjectivesThis study explored PROs in adolescents and adults with TOF and delineated variables associated with PROs. MethodsThis was a cross-sectional observational study within a larger prospective registry of adolescents and adults with repaired TOF and moderate or greater pulmonary regurgitation from North America, Europe, and Asia. Participants completed PROs, including a QOL linear analogue scale (QOL-LAS) and an HS visual analogue scale (HS-VAS). Scores were classified according to age cohorts: <18, 18 to 25, 26 to 40, and >40 years. ResultsThe study included 607 patients (46.3% female; median age 28.5 years). Median QOL-LAS scores (0-100) were similar across age cohorts (85, 80, 80, 80; P = 0.056). Median HS-VAS scores (0-100) were lowest for the oldest cohort (77) compared with the 3 younger cohorts (85, 80, 80) (P = 0.004). With advancing age, there were increased reports of poor mobility (P < 0.001) and pain or discomfort (P = 0.004); problems in these dimensions were reported by 19.1% and 37.2% of patients aged >40 years, respectively. Of factors associated with superior PROs on multivariable regression modeling (ie, being White, being nonsyndromic, having employment, and having better left ventricular function; P < 0.05), asymptomatic status (functional class I) was the variable associated with the greatest number of QOL and HS measures (P < 0.001). ConclusionsStrategies to improve TOF outcomes should consider PROs alongside conventional clinical variables. Factors associated with poorer PROs represent opportunities to intervene to improve the lives of patients with TOF. |
Persistent Identifier | http://hdl.handle.net/10722/328454 |
ISSN | 2023 Impact Factor: 21.7 2023 SCImago Journal Rankings: 8.762 |
DC Field | Value | Language |
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dc.contributor.author | Kovacs, Adrienne H | - |
dc.contributor.author | Lebovic, Gerald | - |
dc.contributor.author | Raptis, Stavroula | - |
dc.contributor.author | Blais, Samuel | - |
dc.contributor.author | Caldarone, Christopher A | - |
dc.contributor.author | Dahdah, Nagib | - |
dc.contributor.author | Dallaire, Frédéric | - |
dc.contributor.author | Drolet, Christian | - |
dc.contributor.author | Grewal, Jasmine | - |
dc.contributor.author | Hancock, Friesen Camille L | - |
dc.contributor.author | Hickey, Edward | - |
dc.contributor.author | Karur, Gauri Rani | - |
dc.contributor.author | Khairy, Paul | - |
dc.contributor.author | Leonardi, Benedetta | - |
dc.contributor.author | Keir, Michelle | - |
dc.contributor.author | McCrindle, Brian W | - |
dc.contributor.author | Nadeem, Syed Najaf | - |
dc.contributor.author | Ng, Ming-Yen | - |
dc.contributor.author | Shah, Ashish H | - |
dc.contributor.author | Tham, Edythe B | - |
dc.contributor.author | Therrien, Judith | - |
dc.contributor.author | Warren, Andrew E | - |
dc.contributor.author | Vonder, Muhll Isabelle F | - |
dc.contributor.author | Van de Bruaene, Alexander | - |
dc.contributor.author | Yamamura, Kenichiro | - |
dc.contributor.author | Farkouh, Michael E | - |
dc.contributor.author | Wald, Rachel M | - |
dc.date.accessioned | 2023-06-28T04:45:06Z | - |
dc.date.available | 2023-06-28T04:45:06Z | - |
dc.date.issued | 2023-05-10 | - |
dc.identifier.citation | Journal of the American College of Cardiology, 2023, v. 81, n. 19, p. 1937-1950 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328454 | - |
dc.description.abstract | <h3>Background</h3><p>Comprehensive assessment of <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/fallot-tetralogy" title="Learn more about tetralogy of Fallot from ScienceDirect's AI-generated Topic Pages">tetralogy of Fallot</a> (TOF) outcomes extends beyond morbidity and mortality to incorporate patient-reported outcomes (PROs), including quality of life (QOL) and health status (HS).</p><h3>Objectives</h3><p>This study explored PROs in adolescents and adults with TOF and delineated variables associated with PROs.</p><h3>Methods</h3><p>This was a cross-sectional observational study within a larger prospective registry of adolescents and adults with repaired TOF and moderate or greater <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/pulmonary-valve-insufficiency" title="Learn more about pulmonary regurgitation from ScienceDirect's AI-generated Topic Pages">pulmonary regurgitation</a> from North America, Europe, and Asia. Participants completed PROs, including a QOL linear analogue scale (QOL-LAS) and an HS <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/visual-analog-scale" title="Learn more about visual analogue scale from ScienceDirect's AI-generated Topic Pages">visual analogue scale</a> (HS-VAS). Scores were classified according to age cohorts: <18, 18 to 25, 26 to 40, and >40 years.</p><h3>Results</h3><p>The study included 607 patients (46.3% female; median age 28.5 years). Median QOL-LAS scores (0-100) were similar across age cohorts (85, 80, 80, 80; <em>P</em> = 0.056). Median HS-VAS scores (0-100) were lowest for the oldest cohort (77) compared with the 3 younger cohorts (85, 80, 80) (<em>P</em> = 0.004). With advancing age, there were increased reports of poor mobility (<em>P</em> < 0.001) and pain or discomfort (<em>P</em> = 0.004); problems in these dimensions were reported by 19.1% and 37.2% of patients aged >40 years, respectively. Of factors associated with superior PROs on multivariable regression modeling (ie, being White, being nonsyndromic, having employment, and having better <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-left-ventricle-function" title="Learn more about left ventricular function from ScienceDirect's AI-generated Topic Pages">left ventricular function</a>; <em>P</em> < 0.05), asymptomatic status (functional class I) was the variable associated with the greatest number of QOL and HS measures (P < 0.001).</p><h3>Conclusions</h3><p>Strategies to improve TOF outcomes should consider PROs alongside conventional clinical variables. Factors associated with poorer PROs represent opportunities to intervene to improve the lives of patients with TOF.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Journal of the American College of Cardiology | - |
dc.title | Patient-Reported Outcomes After Tetralogy of Fallot Repair | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jacc.2023.03.385 | - |
dc.identifier.volume | 81 | - |
dc.identifier.issue | 19 | - |
dc.identifier.spage | 1937 | - |
dc.identifier.epage | 1950 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.identifier.issnl | 0735-1097 | - |