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Article: Molecular characteristics of Asian male BRCA-related cancers

TitleMolecular characteristics of Asian male BRCA-related cancers
Authors
Issue Date1-Apr-2023
PublisherSpringer
Citation
Breast Cancer Research and Treatment, 2023, v. 198, p. 391-400 How to Cite?
Abstract

Purpose

Germline mutations of BRCA1 or BRCA2 predispose men to develop various cancers, including breast cancers and prostate cancers. Male breast cancer (MBC) is a rare disease while prostate cancer (PRC) is uncommon in young men at the age of less than 40. The prevalence of BRCA genes in Asian male patients has to be elevated.

Methods

Germline mutations screening was performed in 98 high-risk Chinese MBC and PRC patients.

Result

We have identified 16 pathogenic BRCA2 mutation carriers, 12 were MBC patients, 2 were PRC patients and 2 were patients with both MBC and PRC. The mutation percentages were 18.8%, 6.7% and 50% for MBC, PRC and both MBC and PRC patients, respectively. BRCA2 gene mutations confer a significantly higher risk of breast/prostate cancers in men than those with BRCA1 mutations. BRCA mutated MBC patients had a younger age of diagnosis and strong family histories of breast cancers while BRCA mutated PRC patients had strong family histories of ovarian cancers.

Conclusion

Male BRCA carriers with breast cancers or prostate cancers showed distinct clinical and molecular characteristics, a male-specific genetic screening model would be useful to identify male cancer patients who have a high risk of BRCA mutation.


Persistent Identifierhttp://hdl.handle.net/10722/328259
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.267
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, A-
dc.contributor.authorHo, CYS-
dc.contributor.authorShin, VY-
dc.contributor.authorNg, ATL-
dc.contributor.authorChan, TL-
dc.contributor.authorMa, ESK-
dc.date.accessioned2023-06-28T04:40:31Z-
dc.date.available2023-06-28T04:40:31Z-
dc.date.issued2023-04-01-
dc.identifier.citationBreast Cancer Research and Treatment, 2023, v. 198, p. 391-400-
dc.identifier.issn0167-6806-
dc.identifier.urihttp://hdl.handle.net/10722/328259-
dc.description.abstract<h3>Purpose</h3><p>Germline mutations of <em>BRCA1</em> or <em>BRCA2</em> predispose men to develop various cancers, including breast cancers and prostate cancers. Male breast cancer (MBC) is a rare disease while prostate cancer (PRC) is uncommon in young men at the age of less than 40. The prevalence of <em>BRCA</em> genes in Asian male patients has to be elevated.</p><h3>Methods</h3><p>Germline mutations screening was performed in 98 high-risk Chinese MBC and PRC patients.</p><h3>Result</h3><p>We have identified 16 pathogenic <em>BRCA2</em> mutation carriers, 12 were MBC patients, 2 were PRC patients and 2 were patients with both MBC and PRC. The mutation percentages were 18.8%, 6.7% and 50% for MBC, PRC and both MBC and PRC patients, respectively. <em>BRCA2</em> gene mutations confer a significantly higher risk of breast/prostate cancers in men than those with <em>BRCA1</em> mutations. <em>BRCA</em> mutated MBC patients had a younger age of diagnosis and strong family histories of breast cancers while <em>BRCA</em> mutated PRC patients had strong family histories of ovarian cancers.</p><h3>Conclusion</h3><p>Male <em>BRCA</em> carriers with breast cancers or prostate cancers showed distinct clinical and molecular characteristics, a male-specific genetic screening model would be useful to identify male cancer patients who have a high risk of <em>BRCA</em> mutation.</p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofBreast Cancer Research and Treatment-
dc.titleMolecular characteristics of Asian male BRCA-related cancers-
dc.typeArticle-
dc.identifier.doi10.1007/s10549-022-06651-y-
dc.identifier.hkuros344882-
dc.identifier.volume198-
dc.identifier.spage391-
dc.identifier.epage400-
dc.identifier.eissn1573-7217-
dc.identifier.isiWOS:000915627000001-
dc.identifier.issnl0167-6806-

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