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- Publisher Website: 10.1016/j.jaut.2022.102861
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Article: Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target
Title | Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target |
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Authors | |
Keywords | Autoantibody Autoimmunity Inflammation Pathogenesis SLE |
Issue Date | 1-Oct-2022 |
Publisher | Elsevier |
Citation | Journal of Autoimmunity, 2022, v. 132 How to Cite? |
Abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies, especially anti-dsDNA and anti-Sm autoantibodies are highly specific to SLE, and participate in the immune complex formation and inflammatory damage on multiple end-organs such as kidney, skin, and central nervous system (CNS). However, the underlying mechanisms of autoantibody-induced tissue damage and systemic inflammation are still not fully understood. Single cell analysis of autoreactive B cells and monoclonal antibody screening from patients with active SLE has improved our understanding on the origin of autoreactive B cells and the antigen targets of the pathogenic autoantibodies. B cell depletion therapies have been widely studied in the clinics, but the development of more specific therapies against the pathogenic B cell subset and autoantibodies with improved efficacy and safety still remain a big challenge. A more comprehensive autoantibody profiling combined with functional characterization of autoantibodies in diseases development will shed new insights on the etiology and pathogenesis of SLE and guide a specific treatment to individual SLE patients. |
Persistent Identifier | http://hdl.handle.net/10722/328235 |
ISSN | 2023 Impact Factor: 7.9 2023 SCImago Journal Rankings: 2.558 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lou, HT | - |
dc.contributor.author | Ling, GS | - |
dc.contributor.author | Cao, XT | - |
dc.date.accessioned | 2023-06-28T04:39:53Z | - |
dc.date.available | 2023-06-28T04:39:53Z | - |
dc.date.issued | 2022-10-01 | - |
dc.identifier.citation | Journal of Autoimmunity, 2022, v. 132 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328235 | - |
dc.description.abstract | <p><a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/systemic-lupus-erythematosus" title="Learn more about Systemic lupus erythematosus from ScienceDirect's AI-generated Topic Pages">Systemic lupus erythematosus</a> (SLE) is an autoimmune disease characterized by multiple organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies, especially anti-dsDNA and anti-Sm autoantibodies are highly specific to SLE, and participate in the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/antigen-antibody-complex" title="Learn more about immune complex from ScienceDirect's AI-generated Topic Pages">immune complex</a> formation and inflammatory damage on multiple end-organs such as kidney, skin, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/central-nervous-system" title="Learn more about central nervous system from ScienceDirect's AI-generated Topic Pages">central nervous system</a> (CNS). However, the underlying mechanisms of autoantibody-induced tissue damage and <a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/systemic-inflammation" title="Learn more about systemic inflammation from ScienceDirect's AI-generated Topic Pages">systemic inflammation</a> are still not fully understood. <a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/single-cell-analysis" title="Learn more about Single cell analysis from ScienceDirect's AI-generated Topic Pages">Single cell analysis</a> of autoreactive B cells and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/monoclonal-antibody" title="Learn more about monoclonal antibody from ScienceDirect's AI-generated Topic Pages">monoclonal antibody</a> screening from <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/patient" title="Learn more about patients from ScienceDirect's AI-generated Topic Pages">patients</a> with active SLE has improved our understanding on the origin of autoreactive B cells and the antigen targets of the pathogenic autoantibodies. B cell depletion <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about therapies from ScienceDirect's AI-generated Topic Pages">therapies</a> have been widely studied in the clinics, but the development of more specific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about therapies from ScienceDirect's AI-generated Topic Pages">therapies</a> against the pathogenic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/b-lymphocyte-subpopulation" title="Learn more about B cell subset from ScienceDirect's AI-generated Topic Pages">B cell subset</a> and autoantibodies with improved efficacy and safety still remain a big challenge. A more comprehensive autoantibody profiling combined with functional <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/characterization-of-autoantibody" title="Learn more about characterization of autoantibodies from ScienceDirect's AI-generated Topic Pages">characterization of autoantibodies</a> in diseases development will shed new insights on the etiology and pathogenesis of SLE and guide a specific treatment to individual SLE <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/patient" title="Learn more about patients from ScienceDirect's AI-generated Topic Pages">patients</a>.<br></p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Journal of Autoimmunity | - |
dc.subject | Autoantibody | - |
dc.subject | Autoimmunity | - |
dc.subject | Inflammation | - |
dc.subject | Pathogenesis | - |
dc.subject | SLE | - |
dc.title | Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jaut.2022.102861 | - |
dc.identifier.scopus | eid_2-s2.0-85134746608 | - |
dc.identifier.hkuros | 344956 | - |
dc.identifier.volume | 132 | - |
dc.identifier.isi | WOS:000891312300006 | - |
dc.identifier.issnl | 0896-8411 | - |