Dr Ling, Guang Sheng Heidi 寧珖聖
Sustained inflammation causes immune cell dysfunction and forms the common pathological basis for many chronic inflammatory diseases including chronic viral infection, cancer and autoimmunity. A key aspect of immune cell dysfunction that underpins the clinical outcome of these chronic conditions is the development of exhausted CD8+T cells. Nonetheless, reasons for CD8+T cell exhaustion remain incompletely understood. Our laboratory employs the emerging technologies from the field of immunometabolism to assess the effects of sustained inflammation on exhausted T cell differentiation and population diversity. Our long-term goal is to develop metabolism-targeting drugs to regulate T cell immunity in infection, cancer and autoimmunity.
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