File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Asthma, from mild to severe, is an independent prognostic factor for mild to severe Coronavirus disease 2019 (COVID-19)

TitleAsthma, from mild to severe, is an independent prognostic factor for mild to severe Coronavirus disease 2019 (COVID-19)
Authors
Keywordsasthma
COVID-19
invasive mechanical ventilation
prognosis
Issue Date2022
Citation
Clinical Respiratory Journal, 2022, v. 16, n. 4, p. 293-300 How to Cite?
AbstractBackground: Chronic illnesses were reported to be poor prognostic factors associated with severe illness and mortality in Coronavirus disease 2019 (COVID-19) infection. The association with asthma, however, is limited and controversial, especially for mild asthma. Methods: A territory wide retrospective study was conducted to investigate the association between asthma and the prognosis of COVID-19. All patients with laboratory confirmed in Hong Kong for COVID-19 from the 23 January to 30 September 2020 were included in the study. Severe diseases were defined as those who develop respiratory complications, systemic complications, and death. Results: Among the 4498 patients included in the analysis, 165 had asthma, with 141 having mild asthma. Patients with asthma were significantly more likely to require invasive mechanical ventilation (incidence = 17.0% odds ratio [OR] = 4.765, p < 0.001), oxygen therapy (incidence = 39.4%, OR = 3.291, p < 0.001), intensive care unit admission (incidence = 21.2%, OR = 3.625, p < 0.001), and systemic steroid treatment (incidence = 34.5%, OR = 4.178, p < 0.001) and develop shock (incidence = 16.4%, OR = 4.061, p < 0.001), acute kidney injury (incidence = 6.1%, OR = 3.281, p = 0.033), and secondary bacterial infection (incidence = 56.4%, OR = 2.256, p < 0.001). They also had significantly longer length of stay. Similar findings were also found in patients with asthma of the Global Initiative for Asthma (GINA) steps 1 and 2 upon subgroup analysis. Conclusions: Asthma, regardless of severity, is an independent prognostic factor for COVID-19 and is associated with more severe disease with respiratory and systemic complications.
Persistent Identifierhttp://hdl.handle.net/10722/315386
ISSN
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.561
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, Wang Chun-
dc.contributor.authorTam, Anthony Raymond-
dc.contributor.authorHo, James Chung Man-
dc.contributor.authorLam, David Chi Leung-
dc.contributor.authorTam, Terence Chi Chun-
dc.contributor.authorChan, King Pui Florence-
dc.contributor.authorWang, Julie Kwan Ling-
dc.contributor.authorIp, Mary Sau Man-
dc.contributor.authorHung, Ivan Fan Ngai-
dc.date.accessioned2022-08-05T10:18:42Z-
dc.date.available2022-08-05T10:18:42Z-
dc.date.issued2022-
dc.identifier.citationClinical Respiratory Journal, 2022, v. 16, n. 4, p. 293-300-
dc.identifier.issn1752-6981-
dc.identifier.urihttp://hdl.handle.net/10722/315386-
dc.description.abstractBackground: Chronic illnesses were reported to be poor prognostic factors associated with severe illness and mortality in Coronavirus disease 2019 (COVID-19) infection. The association with asthma, however, is limited and controversial, especially for mild asthma. Methods: A territory wide retrospective study was conducted to investigate the association between asthma and the prognosis of COVID-19. All patients with laboratory confirmed in Hong Kong for COVID-19 from the 23 January to 30 September 2020 were included in the study. Severe diseases were defined as those who develop respiratory complications, systemic complications, and death. Results: Among the 4498 patients included in the analysis, 165 had asthma, with 141 having mild asthma. Patients with asthma were significantly more likely to require invasive mechanical ventilation (incidence = 17.0% odds ratio [OR] = 4.765, p < 0.001), oxygen therapy (incidence = 39.4%, OR = 3.291, p < 0.001), intensive care unit admission (incidence = 21.2%, OR = 3.625, p < 0.001), and systemic steroid treatment (incidence = 34.5%, OR = 4.178, p < 0.001) and develop shock (incidence = 16.4%, OR = 4.061, p < 0.001), acute kidney injury (incidence = 6.1%, OR = 3.281, p = 0.033), and secondary bacterial infection (incidence = 56.4%, OR = 2.256, p < 0.001). They also had significantly longer length of stay. Similar findings were also found in patients with asthma of the Global Initiative for Asthma (GINA) steps 1 and 2 upon subgroup analysis. Conclusions: Asthma, regardless of severity, is an independent prognostic factor for COVID-19 and is associated with more severe disease with respiratory and systemic complications.-
dc.languageeng-
dc.relation.ispartofClinical Respiratory Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectasthma-
dc.subjectCOVID-19-
dc.subjectinvasive mechanical ventilation-
dc.subjectprognosis-
dc.titleAsthma, from mild to severe, is an independent prognostic factor for mild to severe Coronavirus disease 2019 (COVID-19)-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/crj.13480-
dc.identifier.pmid35146925-
dc.identifier.pmcidPMC9060123-
dc.identifier.scopuseid_2-s2.0-85124556242-
dc.identifier.volume16-
dc.identifier.issue4-
dc.identifier.spage293-
dc.identifier.epage300-
dc.identifier.eissn1752-699X-
dc.identifier.isiWOS:000754012100001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats