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Article: Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients

TitleRelationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2021, v. 11 n. 1, p. article no. 17208 How to Cite?
AbstractAdvanced lung cancer patients suffer from deteriorated physical function, which negatively impacts physical and psychological health. As little is known about sleep and physical function in this population, this study aimed to examine the association between subjective and objective sleep parameters and physical function among them. 164 advanced lung cancer patients were included. Objective sleep was measured by actigraphy (measured on non-dominant wrist for 72 h), and subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Performance-based physical function was measured by Timed Up and Go Test (TUGT), 6-Minute Walk Test (6MWT), Sit-to-Stand Test, and One-leg Standing Test. Univariable and multivariable regression analyses were employed to examine the association between sleep and physical function. Total sleep time (TST) was significantly associated with the 6MWT (β = 0.259; 95% CI 0.120, 0.398; P < 0.001), TUGT (β = − 0.012; 95% CI = − 0.017, − 0.008; P < 0.001) and Sit-to-Stand Test (β = 0.027; 95% CI = 0.018, 0.035; P < 0.001) after adjustment for multiple covariates. PSQI global score was only significantly associated with TUGT (β = 0.140; 95% CI = 0.000, 0.280; P = 0.050) after adjustment for multiple covariates. Shorter sleep duration significantly predicted poorer physical performance in advanced lung cancer patients, and more attention is required for those with less than 4.3 h of sleep on average. Trial registration: ClinicalTrials.gov, NCT03482323. Registered 29 March 2018, https://clinicaltrials.gov/ct2/show/NCT03482323; ClinicalTrials.gov, NCT04119778. Registered 8 October 2019, https://clinicaltrials.gov/ct2/show/NCT04119778.
Persistent Identifierhttp://hdl.handle.net/10722/306221
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTakemura, N-
dc.contributor.authorCheung, DST-
dc.contributor.authorFong, DYT-
dc.contributor.authorLee, AWM-
dc.contributor.authorLam, TC-
dc.contributor.authorHo, JCM-
dc.contributor.authorKam, TY-
dc.contributor.authorChik, JYK-
dc.contributor.authorLin, CC-
dc.date.accessioned2021-10-20T10:20:31Z-
dc.date.available2021-10-20T10:20:31Z-
dc.date.issued2021-
dc.identifier.citationScientific Reports, 2021, v. 11 n. 1, p. article no. 17208-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/306221-
dc.description.abstractAdvanced lung cancer patients suffer from deteriorated physical function, which negatively impacts physical and psychological health. As little is known about sleep and physical function in this population, this study aimed to examine the association between subjective and objective sleep parameters and physical function among them. 164 advanced lung cancer patients were included. Objective sleep was measured by actigraphy (measured on non-dominant wrist for 72 h), and subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Performance-based physical function was measured by Timed Up and Go Test (TUGT), 6-Minute Walk Test (6MWT), Sit-to-Stand Test, and One-leg Standing Test. Univariable and multivariable regression analyses were employed to examine the association between sleep and physical function. Total sleep time (TST) was significantly associated with the 6MWT (β = 0.259; 95% CI 0.120, 0.398; P < 0.001), TUGT (β = − 0.012; 95% CI = − 0.017, − 0.008; P < 0.001) and Sit-to-Stand Test (β = 0.027; 95% CI = 0.018, 0.035; P < 0.001) after adjustment for multiple covariates. PSQI global score was only significantly associated with TUGT (β = 0.140; 95% CI = 0.000, 0.280; P = 0.050) after adjustment for multiple covariates. Shorter sleep duration significantly predicted poorer physical performance in advanced lung cancer patients, and more attention is required for those with less than 4.3 h of sleep on average. Trial registration: ClinicalTrials.gov, NCT03482323. Registered 29 March 2018, https://clinicaltrials.gov/ct2/show/NCT03482323; ClinicalTrials.gov, NCT04119778. Registered 8 October 2019, https://clinicaltrials.gov/ct2/show/NCT04119778.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsScientific Reports. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRelationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients-
dc.typeArticle-
dc.identifier.emailCheung, DST: denisest@hku.hk-
dc.identifier.emailFong, DYT: dytfong@hku.hk-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.emailLam, TC: lamtc03@hku.hk-
dc.identifier.emailHo, JCM: jhocm@hku.hk-
dc.identifier.authorityCheung, DST=rp02526-
dc.identifier.authorityFong, DYT=rp00253-
dc.identifier.authorityLee, AWM=rp02056-
dc.identifier.authorityLam, TC=rp02128-
dc.identifier.authorityHo, JCM=rp00258-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-021-96481-7-
dc.identifier.pmid34446756-
dc.identifier.pmcidPMC8390480-
dc.identifier.scopuseid_2-s2.0-85113472753-
dc.identifier.hkuros327585-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spagearticle no. 17208-
dc.identifier.epagearticle no. 17208-
dc.identifier.isiWOS:000691021200087-
dc.publisher.placeUnited Kingdom-

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