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Article: The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis

TitleThe effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis
Authors
KeywordsDXA
BIA
CT
Mortality
Lean mass
Issue Date2021
PublisherElsevier B.V and the Korean Society of Osteoporosis. The Journal's web site is located at https://www.journals.elsevier.com/osteoporosis-and-sarcopenia
Citation
Osteoporosis and Sarcopenia, 2021, v. 7 n. suppl. 1, p. S13-S18 How to Cite?
AbstractObjectives: Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities. Methods: A systematic review and meta-analysis of lean mass and mortality was conducted. The analysis was stratified by different measurement modalities and health conditions. Pooled hazard ratios were estimated using a random effects model. Results: This meta-analysis included 188 studies with 98 468 participants. Reduced lean mass measured by BIA, DXA, and CT, was associated with increased risk of mortality with a hazard ratio (HR) of 1.35 (95% CI, 1.21–1.49), 1.18 (95% CI, 1.06–1.30), and 1.44 (95% CI, 1.32–1.57), respectively. Similarly, low lean mass defined by BIA-, DXA-, and CT-measurement was associated with increased risk of mortality, with an HR of 1.81 (95% CI, 1.56–2.10), 1.44 (95% CI, 1.29–1.60), and 1.78 (95% CI, 1.64–1.93). Conclusions: Reduced and low lean mass were robustly associated with increased mortality in studies using different measurement modalities.
Persistent Identifierhttp://hdl.handle.net/10722/304950
ISSN
2023 Impact Factor: 2.5
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, GHY-
dc.contributor.authorLEE, GKY-
dc.contributor.authorAU, PCM-
dc.contributor.authorChan, M-
dc.contributor.authorLi, HL-
dc.contributor.authorCheung, BMY-
dc.contributor.authorWong, ICK-
dc.contributor.authorLee, VHF-
dc.contributor.authorMok, J-
dc.contributor.authorYip, BHK-
dc.contributor.authorCheng, KKY-
dc.contributor.authorWu, CH-
dc.contributor.authorCheung, CL-
dc.date.accessioned2021-10-05T02:37:34Z-
dc.date.available2021-10-05T02:37:34Z-
dc.date.issued2021-
dc.identifier.citationOsteoporosis and Sarcopenia, 2021, v. 7 n. suppl. 1, p. S13-S18-
dc.identifier.issn2405-5255-
dc.identifier.urihttp://hdl.handle.net/10722/304950-
dc.description.abstractObjectives: Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities. Methods: A systematic review and meta-analysis of lean mass and mortality was conducted. The analysis was stratified by different measurement modalities and health conditions. Pooled hazard ratios were estimated using a random effects model. Results: This meta-analysis included 188 studies with 98 468 participants. Reduced lean mass measured by BIA, DXA, and CT, was associated with increased risk of mortality with a hazard ratio (HR) of 1.35 (95% CI, 1.21–1.49), 1.18 (95% CI, 1.06–1.30), and 1.44 (95% CI, 1.32–1.57), respectively. Similarly, low lean mass defined by BIA-, DXA-, and CT-measurement was associated with increased risk of mortality, with an HR of 1.81 (95% CI, 1.56–2.10), 1.44 (95% CI, 1.29–1.60), and 1.78 (95% CI, 1.64–1.93). Conclusions: Reduced and low lean mass were robustly associated with increased mortality in studies using different measurement modalities.-
dc.languageeng-
dc.publisherElsevier B.V and the Korean Society of Osteoporosis. The Journal's web site is located at https://www.journals.elsevier.com/osteoporosis-and-sarcopenia-
dc.relation.ispartofOsteoporosis and Sarcopenia-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDXA-
dc.subjectBIA-
dc.subjectCT-
dc.subjectMortality-
dc.subjectLean mass-
dc.titleThe effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis-
dc.typeArticle-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.authorityCheung, CL=rp01749-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.afos.2021.02.004-
dc.identifier.pmid33997304-
dc.identifier.pmcidPMC8088995-
dc.identifier.hkuros325800-
dc.identifier.volume7-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS13-
dc.identifier.epageS18-
dc.identifier.isiWOS:000895747100003-
dc.publisher.placeUnited States-

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