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Article: Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

TitleRole of Th22 Cells in the Pathogenesis of Autoimmune Diseases
Authors
KeywordsTh22 cells
IL-22
rheumatoid arthritis
systemic lupus erythematosus
psoriasis
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2021, v. 12, p. article no. 688066 How to Cite?
AbstractUpon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets. Th22 cells secrete certain cytokines such as IL-22, IL-13 and TNF-α, but not others, such as IL-17, IL-4, or interferon-γ (IFN-γ), and they express chemokine receptors CCR4, CCR6 and CCR10. Th22 cells were initially found to play a role in skin inflammatory diseases, but recent studies have demonstrated their involvement in the development of various autoimmune diseases. Here, we review research advances in the origin, characteristics and effector mechanisms of Th22 cells, with an emphasis on the role of Th22 cells and their main effector cytokine IL-22 in the pathogenesis of autoimmune diseases. The findings presented here may facilitate the development of new therapeutic strategies for targeting these diseases.
Persistent Identifierhttp://hdl.handle.net/10722/304805
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 1.868
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, Q-
dc.contributor.authorYang, G-
dc.contributor.authorXiao, F-
dc.contributor.authorXie, J-
dc.contributor.authorWang, S-
dc.contributor.authorLu, L-
dc.contributor.authorCui, D-
dc.date.accessioned2021-10-05T02:35:27Z-
dc.date.available2021-10-05T02:35:27Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Immunology, 2021, v. 12, p. article no. 688066-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/304805-
dc.description.abstractUpon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets. Th22 cells secrete certain cytokines such as IL-22, IL-13 and TNF-α, but not others, such as IL-17, IL-4, or interferon-γ (IFN-γ), and they express chemokine receptors CCR4, CCR6 and CCR10. Th22 cells were initially found to play a role in skin inflammatory diseases, but recent studies have demonstrated their involvement in the development of various autoimmune diseases. Here, we review research advances in the origin, characteristics and effector mechanisms of Th22 cells, with an emphasis on the role of Th22 cells and their main effector cytokine IL-22 in the pathogenesis of autoimmune diseases. The findings presented here may facilitate the development of new therapeutic strategies for targeting these diseases.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectTh22 cells-
dc.subjectIL-22-
dc.subjectrheumatoid arthritis-
dc.subjectsystemic lupus erythematosus-
dc.subjectpsoriasis-
dc.titleRole of Th22 Cells in the Pathogenesis of Autoimmune Diseases-
dc.typeArticle-
dc.identifier.emailXiao, F: xiaof@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2021.688066-
dc.identifier.pmid34295334-
dc.identifier.pmcidPMC8290841-
dc.identifier.scopuseid_2-s2.0-85111022963-
dc.identifier.hkuros326229-
dc.identifier.volume12-
dc.identifier.spagearticle no. 688066-
dc.identifier.epagearticle no. 688066-
dc.identifier.isiWOS:000674733400001-
dc.publisher.placeSwitzerland-

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